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DROME:SXL

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Sxl (synonyms: Sx1)
Protein Name(s) Protein sex-lethal
External Links
UniProt P19339
EMBL M23635
M23636
M59447
M59448
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
AE014298
BT003583
BT099922
BT100240
BT120392
S88324
D84425
PIR A31639
A39725
RefSeq NP_001027062.1
NP_001027063.1
NP_001027064.1
NP_001027065.1
NP_001027066.1
NP_001162686.1
NP_001162687.1
NP_001162688.1
NP_001162689.1
NP_001162690.1
NP_001259305.1
NP_001259306.1
NP_524791.3
NP_727160.2
NP_727161.3
NP_727162.2
NP_727163.2
NP_727164.2
NP_727165.2
NP_727166.2
NP_727167.2
NP_727168.1
UniGene Dm.4502
PDB 1B7F
1SXL
2SXL
3SXL
4QQB
PDBsum 1B7F
1SXL
2SXL
3SXL
4QQB
ProteinModelPortal P19339
SMR P19339
IntAct P19339
MINT MINT-276991
PaxDb P19339
PRIDE P19339
EnsemblMetazoa FBtr0331255
FBtr0331262
FBtr0331268
GeneID 3772180
KEGG dme:Dmel_CG43770
UCSC CG18350-RE
CTD 3772180
FlyBase FBgn0264270
eggNOG NOG249299
GeneTree ENSGT00760000118913
InParanoid P19339
OMA NMVHRDG
PhylomeDB P19339
ChiTaRS Sxl
EvolutionaryTrace P19339
GenomeRNAi 3772180
NextBio 852740
Proteomes UP000000803
Bgee P19339
ExpressionAtlas P19339
GO GO:0005737
GO:0043234
GO:0008083
GO:0003730
GO:0048027
GO:0003729
GO:0000166
GO:0008266
GO:0008187
GO:0000900
GO:0000380
GO:0007549
GO:0019099
GO:0030237
GO:0019101
GO:0007281
GO:0007446
GO:0000398
GO:0048025
GO:0017148
GO:0009994
GO:0048477
GO:0007131
GO:0000381
GO:0048024
GO:0006355
GO:0007530
GO:0007541
GO:0007548
GO:0007224
GO:0018993
GO:0006351
Gene3D 3.30.70.330
InterPro IPR002343
IPR012677
IPR000504
IPR006546
Pfam PF00076
PRINTS PR00961
SMART SM00360
TIGRFAMs TIGR01659
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012677

F

Seeded From UniProt

complete

GO:0000380

alternative mRNA splicing, via spliceosome

PMID:12444081[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:19727396[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:12484523[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0000900

translation repressor activity, nucleic acid binding

PMID:12414187[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000504

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002343
InterPro:IPR006546

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003729

mRNA binding

PMID:10908586[5]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0003729

mRNA binding

PMID:12484523[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0003730

mRNA 3'-UTR binding

PMID:16122421[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10521666[7]

IPI: Inferred from Physical Interaction

FB:FBgn0028402

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19013444[8]

IPI: Inferred from Physical Interaction

FB:FBgn0003449

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:22645327[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007131

reciprocal meiotic recombination

PMID:10648226[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007224

smoothened signaling pathway

PMID:16207758[11]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007281

germ cell development

PMID:11131529[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007446

imaginal disc growth

PMID:16207758[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:11092827[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:11105896[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:12596226[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:12683975[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007530

sex determination

PMID:15382141[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007541

sex determination, primary response to X:A ratio

PMID:10648226[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007548

sex differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0726

P

Seeded From UniProt

complete

GO:0007548

sex differentiation

PMID:11300999[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007548

sex differentiation

PMID:12350340[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007549

dosage compensation

PMID:10648226[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007549

dosage compensation

PMID:11105896[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007549

dosage compensation

PMID:12350340[19]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007549

dosage compensation

PMID:12484523[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007549

dosage compensation

PMID:1525829[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007549

dosage compensation

PMID:8970731[21]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008083

growth factor activity

PMID:16207758[11]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008187

poly-pyrimidine tract binding

PMID:10617208[22]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008266

poly(U) RNA binding

PMID:10864047[23]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0009994

oocyte differentiation

PMID:17067567[24]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:11256069[25]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:12414187[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:12508274[26]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:16122421[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:16452508[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0018993

somatic sex determination

PMID:10648226[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0018993

somatic sex determination

PMID:11300999[18]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0018993

somatic sex determination

PMID:12484523[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0019099

female germ-line sex determination

PMID:1525829[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0019099

female germ-line sex determination

PMID:8970731[21]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0019101

female somatic sex determination

PMID:8970731[21]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030237

female sex determination

PMID:10648226[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0043234

protein complex

PMID:19013444[8]

IPI: Inferred from Physical Interaction

FB:FBgn0003449

C

Seeded From UniProt

complete

GO:0048024

regulation of mRNA splicing, via spliceosome

PMID:1525829[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048025

negative regulation of mRNA splicing, via spliceosome

PMID:10617208[22]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048025

negative regulation of mRNA splicing, via spliceosome

PMID:12414187[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048027

mRNA 5'-UTR binding

PMID:12414187[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0048027

mRNA 5'-UTR binding

PMID:16122421[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:10648226[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Ortega, A et al. (2003) Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing. J. Biol. Chem. 278 3040-7 PubMed GONUTS page
  2. Hu, J et al. (2009) Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE 4 e6890 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Saccone, G et al. (2002) Sex determination in flies, fruitflies and butterflies. Genetica 116 15-23 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Dean, KA et al. (2002) Translational repressors in Drosophila. Trends Genet. 18 572-7 PubMed GONUTS page
  5. Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
  6. 6.0 6.1 6.2 Beckmann, K et al. (2005) A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell 122 529-40 PubMed GONUTS page
  7. Dong, Z & Bell, LR (1999) SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal. Gene 237 421-8 PubMed GONUTS page
  8. 8.0 8.1 Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page
  9. Chau, J et al. (2012) Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 9465-70 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page
  11. 11.0 11.1 11.2 Horabin, JI (2005) Splitting the Hedgehog signal: sex and patterning in Drosophila. Development 132 4801-10 PubMed GONUTS page
  12. Deng, W & Lin, H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int. Rev. Cytol. 203 93-138 PubMed GONUTS page
  13. Greenspan, RJ & Ferveur, JF (2000) Courtship in Drosophila. Annu. Rev. Genet. 34 205-232 PubMed GONUTS page
  14. 14.0 14.1 Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page
  15. Stothard, P & Pilgrim, D (2003) Sex-determination gene and pathway evolution in nematodes. Bioessays 25 221-31 PubMed GONUTS page
  16. Charlat, S et al. (2003) Evolutionary consequences of Wolbachia infections. Trends Genet. 19 217-23 PubMed GONUTS page
  17. Beye, M (2004) The dice of fate: the csd gene and how its allelic composition regulates sexual development in the honey bee, Apis mellifera. Bioessays 26 1131-9 PubMed GONUTS page
  18. 18.0 18.1 Baker, BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105 13-24 PubMed GONUTS page
  19. 19.0 19.1 Christiansen, AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet. 18 510-6 PubMed GONUTS page
  20. 20.0 20.1 20.2 Younger-Shepherd, S et al. (1992) deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell 70 911-22 PubMed GONUTS page
  21. 21.0 21.1 21.2 Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page
  22. 22.0 22.1 Merendino, L et al. (1999) Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG. Nature 402 838-41 PubMed GONUTS page
  23. Singh, R et al. (2000) Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal. RNA 6 901-11 PubMed GONUTS page
  24. Wang, Z & Lin, H (2007) Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Dev. Biol. 302 160-8 PubMed GONUTS page
  25. Zarkower, D (2001) Establishing sexual dimorphism: conservation amidst diversity? Nat. Rev. Genet. 2 175-85 PubMed GONUTS page
  26. Graham, P et al. (2003) Masters change, slaves remain. Bioessays 25 1-4 PubMed GONUTS page
  27. Duncan, K et al. (2006) Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev. 20 368-79 PubMed GONUTS page