DROME:SXL

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Sxl (synonyms: Sx1)
Protein Name(s)	Protein sex-lethal
External Links
UniProt	P19339
EMBL	M23635 M23636 M59447 M59448 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 AE014298 BT003583 BT099922 BT100240 BT120392 S88324 D84425
PIR	A31639 A39725
RefSeq	NP_001027062.1 NP_001027063.1 NP_001027064.1 NP_001027065.1 NP_001027066.1 NP_001162686.1 NP_001162687.1 NP_001162688.1 NP_001162689.1 NP_001162690.1 NP_001259305.1 NP_001259306.1 NP_524791.3 NP_727160.2 NP_727161.3 NP_727162.2 NP_727163.2 NP_727164.2 NP_727165.2 NP_727166.2 NP_727167.2 NP_727168.1
UniGene	Dm.4502
PDB	1B7F 1SXL 2SXL 3SXL 4QQB
PDBsum	1B7F 1SXL 2SXL 3SXL 4QQB
ProteinModelPortal	P19339
SMR	P19339
IntAct	P19339
MINT	MINT-276991
PaxDb	P19339
PRIDE	P19339
EnsemblMetazoa	FBtr0331255 FBtr0331262 FBtr0331268
GeneID	3772180
KEGG	dme:Dmel_CG43770
UCSC	CG18350-RE
CTD	3772180
FlyBase	FBgn0264270
eggNOG	NOG249299
GeneTree	ENSGT00760000118913
InParanoid	P19339
OMA	NMVHRDG
PhylomeDB	P19339
ChiTaRS	Sxl
EvolutionaryTrace	P19339
GenomeRNAi	3772180
NextBio	852740
Proteomes	UP000000803
Bgee	P19339
ExpressionAtlas	P19339
GO	GO:0005737 GO:0043234 GO:0008083 GO:0003730 GO:0048027 GO:0003729 GO:0000166 GO:0008266 GO:0008187 GO:0000900 GO:0000380 GO:0007549 GO:0019099 GO:0030237 GO:0019101 GO:0007281 GO:0007446 GO:0000398 GO:0048025 GO:0017148 GO:0009994 GO:0048477 GO:0007131 GO:0000381 GO:0048024 GO:0006355 GO:0007530 GO:0007541 GO:0007548 GO:0007224 GO:0018993 GO:0006351
Gene3D	3.30.70.330
InterPro	IPR002343 IPR012677 IPR000504 IPR006546
Pfam	PF00076
PRINTS	PR00961
SMART	SM00360
TIGRFAMs	TIGR01659
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:1990904	ribonucleoprotein complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0265297 PANTHER:PTN002768817 UniProtKB:P11940 UniProtKB:Q13310	C		Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264270 PANTHER:PTN000610044 UniProtKB:P11940 UniProtKB:Q13310 UniProtKB:Q6XE24	F		Seeded From UniProt	complete
enables	GO:0008143	poly(A) binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000610044 SGD:S000000967 TAIR:locus:2013011 UniProtKB:P11940 UniProtKB:Q13310 UniProtKB:Q6XE24 UniProtKB:Q9H361	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000610044 TAIR:locus:2012161 TAIR:locus:2013011 TAIR:locus:2058573 UniProtKB:P11940 UniProtKB:P29558 UniProtKB:Q13310 UniProtKB:Q9H361	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264270 FB:FBgn0265297 MGI:MGI:1349722 PANTHER:PTN000610044 PomBase:SPAC57A7.04c PomBase:SPBC29A10.02 SGD:S000000967 SGD:S000003969 UniProtKB:Q13310 UniProtKB:Q6XE24 WB:WBGene00003902 WB:WBGene00006331	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000610044 PomBase:SPBC29A10.02 SGD:S000000967 TAIR:locus:2013011 UniProtKB:P11940 UniProtKB:Q13310	C		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264270 FB:FBgn0265297 MGI:MGI:2444477 PANTHER:PTN000610044 UniProtKB:P11940 WB:WBGene00006331	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000114 FB:FBgn0264001 MGI:MGI:1926034 PANTHER:PTN002768817 PomBase:SPAC1610.03c RGD:68347 SGD:S000005846 UniProtKB:O04425 UniProtKB:P0DJD4 UniProtKB:P11940 UniProtKB:Q5SZQ8 UniProtKB:Q8IDB7 UniProtKB:Q8IUH3 UniProtKB:Q92879	F		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:16207758^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(FB:FBgn0004859)	Seeded From UniProt	complete
enables	GO:0036002	pre-mRNA binding	PMID:28675155^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030237	female sex determination	PMID:28675155^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:28675155^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22645327^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:19727396^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19013444^[6]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003449	C		Seeded From UniProt	complete
involved_in	GO:0009994	oocyte differentiation	PMID:17067567^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:16452508^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007446	imaginal disc growth	PMID:16207758^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045880	positive regulation of smoothened signaling pathway	PMID:16207758^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:16122421^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:16122421^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:16122421^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	PMID:10864047^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008187	poly-pyrimidine tract binding	PMID:10617208^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000035	regulation of stem cell division	PMID:26887495^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990399	epithelium regeneration	PMID:26887495^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000380	alternative mRNA splicing, via spliceosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006546	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002343 InterPro:IPR006546	F		Seeded From UniProt	complete
involved_in	GO:0007530	sex determination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006546	P		Seeded From UniProt	complete
involved_in	GO:0007530	sex determination	PMID:15382141^[13] PMID:12596226^[14] PMID:12683975^[15] PMID:11105896^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018993	somatic sex determination	PMID:12484523^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007549	dosage compensation	PMID:12484523^[17] PMID:12350340^[18] PMID:11105896^[16] PMID:8970731^[19] PMID:1525829^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	PMID:12350340^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000900	translation repressor activity, mRNA regulatory element binding	PMID:12414187^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007131	reciprocal meiotic recombination	PMID:10648226^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007541	sex determination, primary response to X:A ratio	PMID:10648226^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:10648226^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048025	negative regulation of mRNA splicing, via spliceosome	PMID:10617208^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048024	regulation of mRNA splicing, via spliceosome	PMID:1525829^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007548	sex differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0726	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Horabin, JI (2005) Splitting the Hedgehog signal: sex and patterning in Drosophila. Development 132 4801-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kan, L et al. (2017) The mA pathway facilitates sex determination in Drosophila. Nat Commun 8 15737 PubMed GONUTS page
↑ Chau, J et al. (2012) Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 9465-70 PubMed GONUTS page
↑ Hu, J et al. (2009) Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE 4 e6890 PubMed GONUTS page
↑ Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page
↑ Wang, Z & Lin, H (2007) Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Dev. Biol. 302 160-8 PubMed GONUTS page
↑ Duncan, K et al. (2006) Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev. 20 368-79 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Beckmann, K et al. (2005) A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell 122 529-40 PubMed GONUTS page
↑ Singh, R et al. (2000) Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal. RNA 6 901-11 PubMed GONUTS page
↑ ^11.0 ^11.1 Merendino, L et al. (1999) Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG. Nature 402 838-41 PubMed GONUTS page
↑ ^12.0 ^12.1 Hudry, B et al. (2016) The sexual identity of adult intestinal stem cells controls organ size and plasticity. Nature 530 344-8 PubMed GONUTS page
↑ Beye, M (2004) The dice of fate: the csd gene and how its allelic composition regulates sexual development in the honey bee, Apis mellifera. Bioessays 26 1131-9 PubMed GONUTS page
↑ Stothard, P & Pilgrim, D (2003) Sex-determination gene and pathway evolution in nematodes. Bioessays 25 221-31 PubMed GONUTS page
↑ Charlat, S et al. (2003) Evolutionary consequences of Wolbachia infections. Trends Genet. 19 217-23 PubMed GONUTS page
↑ ^16.0 ^16.1 Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page
↑ ^17.0 ^17.1 Saccone, G et al. (2002) Sex determination in flies, fruitflies and butterflies. Genetica 116 15-23 PubMed GONUTS page
↑ ^18.0 ^18.1 Christiansen, AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet. 18 510-6 PubMed GONUTS page
↑ Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page
↑ ^20.0 ^20.1 Younger-Shepherd, S et al. (1992) deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell 70 911-22 PubMed GONUTS page
↑ Dean, KA et al. (2002) Translational repressors in Drosophila. Trends Genet. 18 572-7 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16207758-2] 2.0 ^2.1 ^2.2 Horabin, JI (2005) Splitting the Hedgehog signal: sex and patterning in Drosophila. Development 132 4801-10 PubMed GONUTS page

[PMID:28675155-3] 3.0 ^3.1 ^3.2 Kan, L et al. (2017) The mA pathway facilitates sex determination in Drosophila. Nat Commun 8 15737 PubMed GONUTS page

[PMID:22645327-4] Chau, J et al. (2012) Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 9465-70 PubMed GONUTS page

[PMID:19727396-5] Hu, J et al. (2009) Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE 4 e6890 PubMed GONUTS page

[PMID:19013444-6] Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page

[PMID:17067567-7] Wang, Z & Lin, H (2007) Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Dev. Biol. 302 160-8 PubMed GONUTS page

[PMID:16452508-8] Duncan, K et al. (2006) Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev. 20 368-79 PubMed GONUTS page

[PMID:16122421-9] 9.0 ^9.1 ^9.2 Beckmann, K et al. (2005) A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell 122 529-40 PubMed GONUTS page

[PMID:10864047-10] Singh, R et al. (2000) Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal. RNA 6 901-11 PubMed GONUTS page

[PMID:10617208-11] 11.0 ^11.1 Merendino, L et al. (1999) Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG. Nature 402 838-41 PubMed GONUTS page

[PMID:26887495-12] 12.0 ^12.1 Hudry, B et al. (2016) The sexual identity of adult intestinal stem cells controls organ size and plasticity. Nature 530 344-8 PubMed GONUTS page

[PMID:15382141-13] Beye, M (2004) The dice of fate: the csd gene and how its allelic composition regulates sexual development in the honey bee, Apis mellifera. Bioessays 26 1131-9 PubMed GONUTS page

[PMID:12596226-14] Stothard, P & Pilgrim, D (2003) Sex-determination gene and pathway evolution in nematodes. Bioessays 25 221-31 PubMed GONUTS page

[PMID:12683975-15] Charlat, S et al. (2003) Evolutionary consequences of Wolbachia infections. Trends Genet. 19 217-23 PubMed GONUTS page

[PMID:11105896-16] 16.0 ^16.1 Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page

[PMID:12484523-17] 17.0 ^17.1 Saccone, G et al. (2002) Sex determination in flies, fruitflies and butterflies. Genetica 116 15-23 PubMed GONUTS page

[PMID:12350340-18] 18.0 ^18.1 Christiansen, AE et al. (2002) Sex comes in from the cold: the integration of sex and pattern. Trends Genet. 18 510-6 PubMed GONUTS page

[PMID:8970731-19] Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page

[PMID:1525829-20] 20.0 ^20.1 Younger-Shepherd, S et al. (1992) deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell 70 911-22 PubMed GONUTS page

[PMID:12414187-21] Dean, KA et al. (2002) Translational repressors in Drosophila. Trends Genet. 18 572-7 PubMed GONUTS page

[PMID:10648226-22] 22.0 ^22.1 ^22.2 Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page

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DROME:SXL

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