DROME:SNRPA

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	snf (synonyms: D25, fs(1)1621, liz)
Protein Name(s)	U1 small nuclear ribonucleoprotein A U1 snRNP A U1-A U1A Sex determination protein snf
External Links
UniProt	P43332
EMBL	M89775 L29521 AE014298 AY061491
PIR	A54279
RefSeq	NP_511045.1
UniGene	Dm.2625
PDB	2AYM 2B0G 2K3K
PDBsum	2AYM 2B0G 2K3K
ProteinModelPortal	P43332
SMR	P43332
BioGrid	57952
DIP	DIP-23676N
IntAct	P43332
MINT	MINT-1634151
STRING	7227.FBpp0070716
PaxDb	P43332
PRIDE	P43332
EnsemblMetazoa	FBtr0070748
GeneID	31442
KEGG	dme:Dmel_CG4528
CTD	31442
FlyBase	FBgn0003449
eggNOG	NOG317159
GeneTree	ENSGT00390000007046
InParanoid	P43332
OMA	VQPVPGM
OrthoDB	EOG77DJ77
PhylomeDB	P43332
Reactome	REACT_227819
ChiTaRS	snf
EvolutionaryTrace	P43332
GenomeRNAi	31442
NextBio	773664
PRO	PR:P43332
Proteomes	UP000000803
Bgee	P43332
ExpressionAtlas	P43332
GO	GO:0071013 GO:0005634 GO:0071011 GO:0043234 GO:0030529 GO:0030532 GO:0005685 GO:0005686 GO:0042802 GO:0003729 GO:0000166 GO:0008266 GO:0097158 GO:0035614 GO:0030619 GO:0030620 GO:0019099 GO:0000398 GO:0048477 GO:0007539 GO:0000381 GO:0008380
Gene3D	3.30.70.330
InterPro	IPR012677 IPR000504 IPR024888
PANTHER	PTHR10501
Pfam	PF00076
SMART	SM00360
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0035614	snRNA stem-loop binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003449 PANTHER:PTN000827569	F	Seeded From UniProt	complete
enables	GO:0030619	U1 snRNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003449 PANTHER:PTN000052389 SGD:S000000323	F	Seeded From UniProt	complete
part_of	GO:0005685	U1 snRNP	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000052389 PomBase:SPBC4B4.07c RGD:1307416 SGD:S000000323 TAIR:locus:2061976 UniProtKB:P09012	C	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000827569 SGD:S000000323 SGD:S000001448 UniProtKB:P08579	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27514026^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070868	heterochromatin organization involved in chromatin silencing	PMID:27514026^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030619	U1 snRNA binding	PMID:20455544^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0030620	U2 snRNA binding	PMID:20455544^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035614	snRNA stem-loop binding	PMID:20455544^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19727396^[4]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003449	F	Seeded From UniProt	complete
enables	GO:0030619	U1 snRNA binding	PMID:19727396^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:19727396^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:19727396^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008266	poly(U) RNA binding	PMID:19727396^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0097158	pre-mRNA intronic pyrimidine-rich binding	PMID:19727396^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:18981222^[5]	ECO:0000305	curator inference used in manual assertion	GO:0071011,GO:0071013	P	Seeded From UniProt	complete
part_of	GO:0071013	catalytic step 2 spliceosome	PMID:18981222^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071011	precatalytic spliceosome	PMID:18981222^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19013444^[6]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0264270	C	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:15492211^[7]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15492211^[7]	ECO:0000305	curator inference used in manual assertion	GO:0000381	C	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:11156616^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:10908584^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000001448	P	Seeded From UniProt	complete
part_of	GO:0005685	U1 snRNP	PMID:10908584^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000000323	C	Seeded From UniProt	complete
part_of	GO:0005686	U2 snRNP	PMID:10908584^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000001448	C	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:10908584^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000000323	P	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:10908586^[10]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0007539	primary sex determination, soma	PMID:10648226^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019099	female germ-line sex determination	PMID:8970731^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:8846293^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:11151	P	Seeded From UniProt	complete
part_of	GO:0005681	spliceosomal complex	PMID:8846293^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:11151	C	Seeded From UniProt	complete
part_of	GO:0030532	small nuclear ribonucleoprotein complex	PMID:8846293^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:11151	C	Seeded From UniProt	complete
part_of	GO:0030532	small nuclear ribonucleoprotein complex	PMID:8846293^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	PMID:11156988^[14] PMID:10648226^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11156988^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005681	spliceosomal complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0747	C	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Swenson, JM et al. (2016) The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic. Elife 5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Williams, SG & Hall, KB (2010) Coevolution of Drosophila snf protein and its snRNA targets. Biochemistry 49 4571-82 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hu, J et al. (2009) Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE 4 e6890 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
↑ Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page
↑ ^7.0 ^7.1 Park, JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 15974-9 PubMed GONUTS page
↑ Swan, A et al. (2001) Identification of new X-chromosomal genes required for Drosophila oogenesis and novel roles for fs(1)Yb, brainiac and dunce. Genome Res. 11 67-77 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Mount, SM & Salz, HK (2000) Pre-messenger RNA processing factors in the Drosophila genome. J. Cell Biol. 150 F37-44 PubMed GONUTS page
↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page
↑ Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Polycarpou-Schwarz, M et al. (1996) Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. RNA 2 11-23 PubMed GONUTS page
↑ ^14.0 ^14.1 Niessen, M et al. (2001) Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Genetics 157 679-88 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27514026-2] 2.0 ^2.1 Swenson, JM et al. (2016) The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic. Elife 5 PubMed GONUTS page

[PMID:20455544-3] 3.0 ^3.1 ^3.2 Williams, SG & Hall, KB (2010) Coevolution of Drosophila snf protein and its snRNA targets. Biochemistry 49 4571-82 PubMed GONUTS page

[PMID:19727396-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hu, J et al. (2009) Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE 4 e6890 PubMed GONUTS page

[PMID:18981222-5] 5.0 ^5.1 ^5.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page

[PMID:19013444-6] Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page

[PMID:15492211-7] 7.0 ^7.1 Park, JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 15974-9 PubMed GONUTS page

[PMID:11156616-8] Swan, A et al. (2001) Identification of new X-chromosomal genes required for Drosophila oogenesis and novel roles for fs(1)Yb, brainiac and dunce. Genome Res. 11 67-77 PubMed GONUTS page

[PMID:10908584-9] 9.0 ^9.1 ^9.2 ^9.3 Mount, SM & Salz, HK (2000) Pre-messenger RNA processing factors in the Drosophila genome. J. Cell Biol. 150 F37-44 PubMed GONUTS page

[PMID:10908586-10] Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page

[PMID:10648226-11] 11.0 ^11.1 Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page

[PMID:8970731-12] Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page

[PMID:8846293-13] 13.0 ^13.1 ^13.2 ^13.3 Polycarpou-Schwarz, M et al. (1996) Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. RNA 2 11-23 PubMed GONUTS page

[PMID:11156988-14] 14.0 ^14.1 Niessen, M et al. (2001) Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Genetics 157 679-88 PubMed GONUTS page

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DROME:SNRPA

Contents

Annotations

Notes

References

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