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DROME:SNRPA

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) snf (synonyms: D25, fs(1)1621, liz)
Protein Name(s) U1 small nuclear ribonucleoprotein A

U1 snRNP A U1-A U1A Sex determination protein snf

External Links
UniProt P43332
EMBL M89775
L29521
AE014298
AY061491
PIR A54279
RefSeq NP_511045.1
UniGene Dm.2625
PDB 2AYM
2B0G
2K3K
PDBsum 2AYM
2B0G
2K3K
ProteinModelPortal P43332
SMR P43332
BioGrid 57952
DIP DIP-23676N
IntAct P43332
MINT MINT-1634151
STRING 7227.FBpp0070716
PaxDb P43332
PRIDE P43332
EnsemblMetazoa FBtr0070748
GeneID 31442
KEGG dme:Dmel_CG4528
CTD 31442
FlyBase FBgn0003449
eggNOG NOG317159
GeneTree ENSGT00390000007046
InParanoid P43332
OMA VQPVPGM
OrthoDB EOG77DJ77
PhylomeDB P43332
Reactome REACT_227819
ChiTaRS snf
EvolutionaryTrace P43332
GenomeRNAi 31442
NextBio 773664
PRO PR:P43332
Proteomes UP000000803
Bgee P43332
ExpressionAtlas P43332
GO GO:0071013
GO:0005634
GO:0071011
GO:0043234
GO:0030529
GO:0030532
GO:0005685
GO:0005686
GO:0042802
GO:0003729
GO:0000166
GO:0008266
GO:0097158
GO:0035614
GO:0030619
GO:0030620
GO:0019099
GO:0000398
GO:0048477
GO:0007539
GO:0000381
GO:0008380
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
IPR024888
PANTHER PTHR10501
Pfam PF00076
SMART SM00360
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012677

F

Seeded From UniProt

complete

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:15492211[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:19727396[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR024888

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

RefSeq:NP_003083

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

RefSeq:NP_004587

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000000323

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000001448

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:18981222[4]

IC: Inferred by Curator

GO:0071011
GO:0071013

P

Seeded From UniProt

complete

GO:0000398

mRNA splicing, via spliceosome

PMID:8846293[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:11151

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000504

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003729

mRNA binding

PMID:10908586[6]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005515

protein binding

PMID:19013444[7]

IPI: Inferred from Physical Interaction

FB:FBgn0264270

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20221253[8]

IPI: Inferred from Physical Interaction

FB:FBgn0082831

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11156988[9]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:15492211[1]

IC: Inferred by Curator

GO:0000381

C

Seeded From UniProt

complete

GO:0005681

spliceosomal complex

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0747

C

Seeded From UniProt

complete

GO:0005681

spliceosomal complex

PMID:8846293[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:11151

C

Seeded From UniProt

complete

GO:0005685

U1 snRNP

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

RefSeq:NP_004587

C

Seeded From UniProt

complete

GO:0005685

U1 snRNP

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000000323

C

Seeded From UniProt

complete

GO:0005686

U2 snRNP

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

RefSeq:NP_003083

C

Seeded From UniProt

complete

GO:0005686

U2 snRNP

PMID:10908584[3]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000001448

C

Seeded From UniProt

complete

GO:0006397

mRNA processing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

GO:0007539

primary sex determination, soma

PMID:10648226[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0008266

poly(U) RNA binding

PMID:19727396[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008380

RNA splicing

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

GO:0008380

RNA splicing

PMID:10648226[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008380

RNA splicing

PMID:11156988[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0017069

snRNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR024888

F

Seeded From UniProt

complete

GO:0019099

female germ-line sex determination

PMID:8970731[11]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0030529

ribonucleoprotein complex

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0687

C

Seeded From UniProt

complete

GO:0030529

ribonucleoprotein complex

PMID:19727396[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030532

small nuclear ribonucleoprotein complex

PMID:8846293[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030532

small nuclear ribonucleoprotein complex

PMID:8846293[5]

ISS: Inferred from Sequence or Structural Similarity

HGNC:11151

C

Seeded From UniProt

complete

GO:0030619

U1 snRNA binding

PMID:19727396[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0030619

U1 snRNA binding

PMID:20455544[12]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0030620

U2 snRNA binding

PMID:20455544[12]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0035614

snRNA stem-loop binding

PMID:20455544[12]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:19727396[2]

IPI: Inferred from Physical Interaction

FB:FBgn0003449

F

Seeded From UniProt

complete

GO:0043234

protein complex

PMID:19013444[7]

IPI: Inferred from Physical Interaction

FB:FBgn0264270

C

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:11156616[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:3089870[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0071011

precatalytic spliceosome

PMID:18981222[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0071013

catalytic step 2 spliceosome

PMID:18981222[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0097158

pre-mRNA intronic pyrimidine-rich binding

PMID:19727396[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Park, JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 15974-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Hu, J et al. (2009) Structure and novel functional mechanism of Drosophila SNF in sex-lethal splicing. PLoS ONE 4 e6890 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Mount, SM & Salz, HK (2000) Pre-messenger RNA processing factors in the Drosophila genome. J. Cell Biol. 150 F37-44 PubMed GONUTS page
  4. 4.0 4.1 4.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Polycarpou-Schwarz, M et al. (1996) Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. RNA 2 11-23 PubMed GONUTS page
  6. Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
  7. 7.0 7.1 Kalifa, Y et al. (2009) Glorund interactions in the regulation of gurken and oskar mRNAs. Dev. Biol. 326 68-74 PubMed GONUTS page
  8. Johnson, ML et al. (2010) PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila. PLoS Genet. 6 e1000872 PubMed GONUTS page
  9. 9.0 9.1 Niessen, M et al. (2001) Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Genetics 157 679-88 PubMed GONUTS page
  10. 10.0 10.1 Schütt, C & Nöthiger, R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127 667-77 PubMed GONUTS page
  11. Williamson, A & Lehmann, R (1996) Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12 365-91 PubMed GONUTS page
  12. 12.0 12.1 12.2 Williams, SG & Hall, KB (2010) Coevolution of Drosophila snf protein and its snRNA targets. Biochemistry 49 4571-82 PubMed GONUTS page
  13. Swan, A et al. (2001) Identification of new X-chromosomal genes required for Drosophila oogenesis and novel roles for fs(1)Yb, brainiac and dunce. Genome Res. 11 67-77 PubMed GONUTS page
  14. Perrimon, N et al. (1986) X-linked female-sterile loci in Drosophila melanogaster. Genetics 113 695-712 PubMed GONUTS page