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DROME:RAD50

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) rad50
Protein Name(s) DNA repair protein RAD50
External Links
UniProt Q9W252
EMBL AE013599
BT003555
FJ219324
FJ219329
FJ219330
FJ219331
FJ219332
FJ219333
FJ219334
FJ219335
FJ219336
FJ219337
FJ219338
FJ219339
FJ219340
FJ219341
FJ219342
FJ219343
FJ219344
FJ219345
FJ219346
FJ219347
FJ219348
FJ219349
FJ219350
AY052106
RefSeq NP_726199.3
ProteinModelPortal Q9W252
SMR Q9W252
BioGrid 63180
IntAct Q9W252
MINT MINT-832947
PaxDb Q9W252
PRIDE Q9W252
EnsemblMetazoa FBtr0301668
GeneID 37564
KEGG dme:Dmel_CG6339
UCSC CG6339-RB
CTD 10111
FlyBase FBgn0034728
eggNOG COG0419
GeneTree ENSGT00390000018781
InParanoid Q9W252
KO K10866
OMA VKDIENY
OrthoDB EOG725DGM
PhylomeDB Q9W252
Reactome REACT_180253
REACT_184320
REACT_220005
GenomeRNAi 37564
NextBio 804309
Proteomes UP000000803
Bgee Q9W252
ExpressionAtlas Q9W252
GO GO:0000781
GO:0000793
GO:0030870
GO:0005634
GO:0005524
GO:0003690
GO:0004518
GO:0008270
GO:0006974
GO:0051276
GO:0006302
GO:0051321
GO:0008104
GO:0016233
GO:0000723
GO:0000722
Gene3D 3.40.50.300
InterPro IPR027417
IPR004584
IPR013134
PANTHER PTHR18867
Pfam PF04423
SUPFAM SSF52540
TIGRFAMs TIGR00606
PROSITE PS51131

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000723

telomere maintenance

PMID:15296753[1]

ECO:0000315

P

Figure 2A and Table 1: DAPI-stained preparations of colchicine-treated larval brains from rad50 or mre11 single mutants and mre11 rad50 double mutants showed high frequencies of both telomeric fusions and chromosome breaks

complete
CACAO 2575

involved_in

GO:0000723

telomere maintenance

PMID:15296753[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008104

protein localization

PMID:15296753[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:15135728[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:15135728[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12753

F

Seeded From UniProt

complete

part_of

GO:0000793

condensed chromosome

PMID:15296753[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000722

telomere maintenance via recombination

PMID:15296753[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070192

chromosome organization involved in meiotic cell cycle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109292
PANTHER:PTN000429848

P

Seeded From UniProt

complete

enables

GO:0051880

G-quadruplex DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
SGD:S000005194

F

Seeded From UniProt

complete

enables

GO:0043047

single-stranded telomeric DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
SGD:S000005194

F

Seeded From UniProt

complete

part_of

GO:0035861

site of double-strand break

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

C

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

P

Seeded From UniProt

complete

part_of

GO:0030870

Mre11 complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

C

Seeded From UniProt

complete

involved_in

GO:0016233

telomere capping

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034728
PANTHER:PTN000429848
TAIR:locus:2045437

P

Seeded From UniProt

complete

contributes_to

GO:0008408

3'-5' exonuclease activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

P

Seeded From UniProt

complete

enables

GO:0004017

adenylate kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
SGD:S000005194

F

Seeded From UniProt

complete

contributes_to

GO:0004003

ATP-dependent DNA helicase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

F

Seeded From UniProt

complete

enables

GO:0003691

double-stranded telomeric DNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
SGD:S000005194

F

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
RGD:621542

C

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
RGD:621542

C

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

C

Seeded From UniProt

complete

involved_in

GO:0000722

telomere maintenance via recombination

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034728
PANTHER:PTN000429848
PomBase:SPAC1556.01c
SGD:S000005194

P

Seeded From UniProt

complete

contributes_to

GO:0000014

single-stranded DNA endodeoxyribonuclease activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000429848
UniProtKB:Q92878

F

Seeded From UniProt

complete

involved_in

GO:0051276

chromosome organization

PMID:16648644[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016233

telomere capping

PMID:16648644[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16648644[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

PMID:15296753[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051276

chromosome organization

PMID:15296753[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046940

nucleoside monophosphate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004017

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008408

P

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004584

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004584

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004584

P

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004584

F

Seeded From UniProt

complete

part_of

GO:0030870

Mre11 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004584

C

Seeded From UniProt

complete

part_of

GO:0030870

Mre11 complex

PMID:15296753[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0779
UniProtKB-SubCell:SL-0276

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ciapponi, L et al. (2004) The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr. Biol. 14 1360-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 Gorski, MM et al. (2004) Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae. DNA Repair (Amst.) 3 603-15 PubMed GONUTS page
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Ciapponi, L et al. (2006) The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Genetics 173 1447-54 PubMed GONUTS page
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