DROME:PTP99

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Ptp99A
Protein Name(s)	Tyrosine-protein phosphatase 99A Receptor-linked protein-tyrosine phosphatase 99A DPTP99A
External Links
UniProt	P35832
EMBL	M80464 M80539 M81795 AE014297 AE014297 AE014297 AE014297
PIR	A41622
RefSeq	NP_476816.1 NP_733288.1 NP_996302.1
UniGene	Dm.4029
ProteinModelPortal	P35832
SMR	P35832
BioGrid	68335
PaxDb	P35832
GeneID	43469
KEGG	dme:Dmel_CG11516
CTD	43469
FlyBase	FBgn0004369
eggNOG	COG5599
HOGENOM	HOG000148805
InParanoid	P35832
KO	K16667
OrthoDB	EOG7288S7
PhylomeDB	P35832
ChiTaRS	Ptp99A
GenomeRNAi	43469
NextBio	834086
Proteomes	UP000000803
Bgee	P35832
ExpressionAtlas	P35832
GO	GO:0030424 GO:0016021 GO:0005886 GO:0004725 GO:0005001 GO:0007414 GO:0007415 GO:0008045 GO:0035335 GO:0006470
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR013783 IPR029021 IPR000387 IPR016130 IPR000242
Pfam	PF00041 PF00102
PRINTS	PR00700
SMART	SM00060 SM00194
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0030424	axon	PMID:18237413^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:11178866^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000464,FB:FBgn0004370	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:10908587^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:10908587^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007415	defasciculation of motor neuron axon	PMID:8598046^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0014007	P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:8598046^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0014007	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:1662390^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	HGNC:9671	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:1662390^[5]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
involved_in	GO:0006470	protein dephosphorylation	PMID:1657402^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	protein_id:CAA38067.1	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:1657402^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	protein_id:CAA38067.1	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:1657402^[6]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
enables	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	PMID:1657401^[7]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
part_of	GO:0005886	plasma membrane	PMID:1657401^[7]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005001	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F	Seeded From UniProt	complete
involved_in	GO:0007414	axonal defasciculation	PMID:9529614^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page
↑ Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page
↑ ^3.0 ^3.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Desai, CJ et al. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84 599-609 PubMed GONUTS page
↑ ^5.0 ^5.1 Hariharan, IK et al. (1991) Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 88 11266-70 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Tian, SS et al. (1991) Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo. Cell 67 675-85 PubMed GONUTS page
↑ ^7.0 ^7.1 Yang, XH et al. (1991) Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Cell 67 661-73 PubMed GONUTS page
↑ Van Vactor, D et al. (1998) Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Genet. Dev. 8 112-26 PubMed GONUTS page

[PMID:18237413-1] Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page

[PMID:11178866-2] Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page

[PMID:10908587-3] 3.0 ^3.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page

[PMID:8598046-4] 4.0 ^4.1 Desai, CJ et al. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84 599-609 PubMed GONUTS page

[PMID:1662390-5] 5.0 ^5.1 Hariharan, IK et al. (1991) Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 88 11266-70 PubMed GONUTS page

[PMID:1657402-6] 6.0 ^6.1 ^6.2 Tian, SS et al. (1991) Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo. Cell 67 675-85 PubMed GONUTS page

[PMID:1657401-7] 7.0 ^7.1 Yang, XH et al. (1991) Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Cell 67 661-73 PubMed GONUTS page

[PMID:9529614-8] Van Vactor, D et al. (1998) Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Genet. Dev. 8 112-26 PubMed GONUTS page

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DROME:PTP99

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