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DROME:PTP99

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Ptp99A
Protein Name(s) Tyrosine-protein phosphatase 99A

Receptor-linked protein-tyrosine phosphatase 99A DPTP99A

External Links
UniProt P35832
EMBL M80464
M80539
M81795
AE014297
AE014297
AE014297
AE014297
PIR A41622
RefSeq NP_476816.1
NP_733288.1
NP_996302.1
UniGene Dm.4029
ProteinModelPortal P35832
SMR P35832
BioGrid 68335
PaxDb P35832
GeneID 43469
KEGG dme:Dmel_CG11516
CTD 43469
FlyBase FBgn0004369
eggNOG COG5599
HOGENOM HOG000148805
InParanoid P35832
KO K16667
OrthoDB EOG7288S7
PhylomeDB P35832
ChiTaRS Ptp99A
GenomeRNAi 43469
NextBio 834086
Proteomes UP000000803
Bgee P35832
ExpressionAtlas P35832
GO GO:0030424
GO:0016021
GO:0005886
GO:0004725
GO:0005001
GO:0007414
GO:0007415
GO:0008045
GO:0035335
GO:0006470
Gene3D 2.60.40.10
3.90.190.10
InterPro IPR003961
IPR013783
IPR029021
IPR000387
IPR016130
IPR000242
Pfam PF00041
PF00102
PRINTS PR00700
SMART SM00060
SM00194
SUPFAM SSF49265
SSF52799
PROSITE PS50853
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:10908587[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:1657402[2]

ISS: Inferred from Sequence or Structural Similarity

protein_id:CAA38067.1

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:1662390[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9671

F

Seeded From UniProt

complete

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

PMID:1657401[4]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:1657401[4]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:1657402[2]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:1662390[3]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:20462449[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:1657402[2]

ISS: Inferred from Sequence or Structural Similarity

protein_id:CAA38067.1

P

Seeded From UniProt

complete

GO:0007414

axonal defasciculation

PMID:9529614[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007415

defasciculation of motor neuron axon

PMID:8598046[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0014007

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:11178866[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0000464
FB:FBgn0004370

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:8598046[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0014007

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016311

dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0030424

axon

PMID:18237413[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:1657401[4]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:1657402[2]

ISS: Inferred from Sequence or Structural Similarity

protein_id:CAA38067.1

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:1662390[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9671

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Tian, SS et al. (1991) Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo. Cell 67 675-85 PubMed GONUTS page
  3. 3.0 3.1 3.2 Hariharan, IK et al. (1991) Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 88 11266-70 PubMed GONUTS page
  4. 4.0 4.1 4.2 Yang, XH et al. (1991) Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Cell 67 661-73 PubMed GONUTS page
  5. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  6. Van Vactor, D et al. (1998) Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Genet. Dev. 8 112-26 PubMed GONUTS page
  7. 7.0 7.1 Desai, CJ et al. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84 599-609 PubMed GONUTS page
  8. Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page
  9. Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page