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PMID:1662390
| Citation |
Hariharan, IK, Chuang, PT and Rubin, GM (1991) Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 88:11266-70 |
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| Abstract |
We have cloned and characterized cDNAs coding for a receptor-class phosphotyrosine phosphatase gene from Drosophila melanogaster. The gene maps to the polytene chromosome bands 99A7-8. The cDNA clones code for a polypeptide of 1301 amino acids with a predicted molecular mass of 145 kDa. The extracellular domain includes two fibronectin-type III-like domains. The cytoplasmic region contains two tandemly repeated phosphotyrosine phosphatase-like domains. Residues shown crucial for catalytic activity are absent in the second domain. This Drosophila receptor-class phosphotyrosine phosphatase polypeptide is expressed on axons of the embryonic central nervous system. |
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| Keywords |
Amino Acid Sequence; Animals; Antibodies; Axons/enzymology; Base Sequence; Chromosome Banding; Cloning, Molecular; DNA Probes; Drosophila melanogaster/embryology; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Fibronectins/genetics; Humans; Molecular Sequence Data; Nervous System/enzymology; Oligodeoxyribonucleotides; Polymerase Chain Reaction/methods; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/isolation & purification; Receptors, Cell Surface/genetics; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Sequence Homology, Nucleic Acid |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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