PMID:1657401

Citation	Yang, XH, Seow, KT, Bahri, SM, Oon, SH and Chia, W (1991) Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Cell 67:661-73
Abstract	Two Drosophila receptor-like tyrosine phosphatase genes, DPTP99A and DPTP10D, were characterized. Protein products of these genes show distinct expression patterns specific to subsets of developing CNS axons. DPTP99A expression coincides with the onset of axonogenesis and is expressed in several pioneer neurons, including aCC and RP2, which pioneer the intersegmental nerve; its proteins are transiently expressed in the intersegmental and segmental nerves, arguing for a role in the establishment of these nerves. Both genes produce complex sets of transcripts, owing to the alternative utilization of exons and polyadenylation sites. Each gene produces alternative protein forms, which differ in their C-terminal tails. The deduced proteins possess extracellular FN-III repeats and intracellular PTPase domain(s). We discuss the implications of these results and the role of protein tyrosine dephosphorylation in axon outgrowth and guidance.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Axons/physiology; Base Sequence; Central Nervous System/embryology; Chromosome Mapping; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Gene Expression; Genes; Immunohistochemistry; Membrane Glycoproteins/genetics; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotides/chemistry; Protein Tyrosine Phosphatases/genetics; RNA Splicing; RNA, Messenger/genetics; Receptors, Cell Surface/physiology; Restriction Mapping; Transcription, Genetic
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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