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PMID:8598046

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Citation

Desai, CJ, Gindhart, JG Jr, Goldstein, LS and Zinn, K (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84:599-609

Abstract

The receptor tyrosine phosphatases DPTP69D and DPTP99A are expressed on motor axons in Drosophila embryos. In mutant embryos lacking DPTP69D protein, motor neuron growth cones stop growing before reaching their muscle targets, or follow incorrect pathways that bypass these muscles. Mutant embryos lacking DPTP99A are indistinguishable from wild type. Motor axon defects in dptp69D dptp99A double mutant embryos, however, are much more severe than in embryos lacking only DPTP69D. Our results demonstrate that DPTP69D and DPTP99A are required for motor axon guidance and that they have partially redundant functions during development of the neuro-muscular system.

Links

PubMed

Keywords

Animals; Axons/enzymology; Central Nervous System/cytology; Central Nervous System/metabolism; Drosophila/embryology; Drosophila/enzymology; Embryo, Nonmammalian/enzymology; Genes, Insect/physiology; Motor Neurons/enzymology; Motor Neurons/ultrastructure; Mutation/physiology; Neural Pathways; Phenotype; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:PTP99

involved_in

GO:0007415: defasciculation of motor neuron axon

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0014007

P

Seeded From UniProt

complete

DROME:PTP99

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0014007

P

Seeded From UniProt

complete

DROME:PTP69

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PTP69

involved_in

GO:0008045: motor neuron axon guidance

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004369

P

Seeded From UniProt

complete

DROME:PTP69

involved_in

GO:0007415: defasciculation of motor neuron axon

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PTP69

involved_in

GO:0007415: defasciculation of motor neuron axon

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004369

P

Seeded From UniProt

complete

See also

References

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