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PMID:8598046
| Citation |
Desai, CJ, Gindhart, JG Jr, Goldstein, LS and Zinn, K (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell 84:599-609 |
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| Abstract |
The receptor tyrosine phosphatases DPTP69D and DPTP99A are expressed on motor axons in Drosophila embryos. In mutant embryos lacking DPTP69D protein, motor neuron growth cones stop growing before reaching their muscle targets, or follow incorrect pathways that bypass these muscles. Mutant embryos lacking DPTP99A are indistinguishable from wild type. Motor axon defects in dptp69D dptp99A double mutant embryos, however, are much more severe than in embryos lacking only DPTP69D. Our results demonstrate that DPTP69D and DPTP99A are required for motor axon guidance and that they have partially redundant functions during development of the neuro-muscular system. |
| Links | |
| Keywords |
Animals; Axons/enzymology; Central Nervous System/cytology; Central Nervous System/metabolism; Drosophila/embryology; Drosophila/enzymology; Embryo, Nonmammalian/enzymology; Genes, Insect/physiology; Motor Neurons/enzymology; Motor Neurons/ultrastructure; Mutation/physiology; Neural Pathways; Phenotype; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0007415: defasciculation of motor neuron axon |
ECO:0000316: genetic interaction evidence used in manual assertion |
FB:FBgn0014007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008045: motor neuron axon guidance |
ECO:0000316: genetic interaction evidence used in manual assertion |
FB:FBgn0014007 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008045: motor neuron axon guidance |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008045: motor neuron axon guidance |
ECO:0000316: genetic interaction evidence used in manual assertion |
FB:FBgn0004369 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007415: defasciculation of motor neuron axon |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007415: defasciculation of motor neuron axon |
ECO:0000316: genetic interaction evidence used in manual assertion |
FB:FBgn0004369 |
P |
Seeded From UniProt |
complete | ||
See also
References
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