DROME:LAR

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Lar
Protein Name(s)	Tyrosine-protein phosphatase Lar Protein-tyrosine-phosphate phosphohydrolase dLAR
External Links
UniProt	P16621
EMBL	M27700 U36857 U36849 U36850 U36851 U36852 U36853 U36854 U36855 U36856 AE014134 AY051985
PIR	A36182
RefSeq	NP_523604.2
UniGene	Dm.24416
PDB	2YD1 3PXJ
PDBsum	2YD1 3PXJ
ProteinModelPortal	P16621
SMR	P16621
BioGrid	61235
DIP	DIP-38648N
IntAct	P16621
MINT	MINT-8310371
PaxDb	P16621
PRIDE	P16621
EnsemblMetazoa	FBtr0081260
GeneID	35259
KEGG	dme:Dmel_CG10443
UCSC	CG10443-RA
CTD	104121
FlyBase	FBgn0000464
eggNOG	COG5599
GeneTree	ENSGT00760000118900
InParanoid	P16621
KO	K05695
OrthoDB	EOG7M98FB
PhylomeDB	P16621
Reactome	REACT_269952
EvolutionaryTrace	P16621
GenomeRNAi	35259
NextBio	792660
Proteomes	UP000000803
Bgee	P16621
ExpressionAtlas	P16621
GO	GO:0030424 GO:0005925 GO:0016021 GO:0005875 GO:0005886 GO:0008201 GO:0004725 GO:0032093 GO:0005001 GO:0048675 GO:0007411 GO:0007412 GO:0007155 GO:0001700 GO:0008045 GO:0007399 GO:0048477 GO:0035335 GO:0008594 GO:0006470 GO:0045467 GO:0048841 GO:0008360 GO:0031290 GO:0051124
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR007110 IPR013783 IPR013098 IPR003598 IPR029021 IPR000387 IPR016130 IPR000242
Pfam	PF00041 PF07679 PF00102
PRINTS	PR00700
SMART	SM00060 SM00408 SM00194
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS50835 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:21931847^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:25361961^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903386	negative regulation of homophilic cell adhesion	PMID:24174674^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0028482	P	Seeded From UniProt	complete
enables	GO:0032093	SAM domain binding	PMID:21430143^[4]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0033987	F	Seeded From UniProt	complete
	GO:0004725	protein tyrosine phosphatase activity	PMID:21931847^[1]	ECO:0000314			F	Figure 2a/b/h/j. Phosphatase activity and substrate recognition features of the different DLAR constructs.	complete CACAO 1982
part_of	GO:0005925	focal adhesion	PMID:21430143^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0032093	SAM domain binding	PMID:21084592^[5]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0034720	F	Seeded From UniProt	complete
involved_in	GO:0007412	axon target recognition	PMID:21084592^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:18516287^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051124	synaptic growth at neuromuscular junction	PMID:19889974^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:19889974^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045467	R7 cell development	PMID:19889974^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048675	axon extension	PMID:19766621^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:19766621^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048841	regulation of axon extension involved in axon guidance	PMID:19766621^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:18237413^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045467	R7 cell development	PMID:18400161^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	PMID:16864799^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008594	photoreceptor cell morphogenesis	PMID:16864797^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045467	R7 cell development	PMID:16864797^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:16213816^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:12972609^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:12972609^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:11178866^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004370	P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:11178866^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004369,FB:FBgn0004370	P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:8598047^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:8598047^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	PMID:2554325^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:2554325^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060269	centripetally migrating follicle cell migration	PMID:28292425^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0120034	positive regulation of plasma membrane bounded cell projection assembly	PMID:26903538^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	PMID:26903538^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:28292425^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:28292425^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:11493634^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Madan, LL et al. (2011) Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. PLoS ONE 6 e24766 PubMed GONUTS page
↑ Yu, J et al. (2015) Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Hum. Mol. Genet. 24 1493-503 PubMed GONUTS page
↑ Cameron, S et al. (2013) Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless. J. Neurosci. 33 17413-21 PubMed GONUTS page
↑ ^4.0 ^4.1 Weng, YL et al. (2011) The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. J. Neurosci. 31 4421-33 PubMed GONUTS page
↑ ^5.0 ^5.1 Astigarraga, S et al. (2010) Three Drosophila liprins interact to control synapse formation. J. Neurosci. 30 15358-68 PubMed GONUTS page
↑ Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hofmeyer, K & Treisman, JE (2009) The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism. Proc. Natl. Acad. Sci. U.S.A. 106 19399-404 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Prakash, S et al. (2009) Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Dev. Biol. 336 10-9 PubMed GONUTS page
↑ Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page
↑ Nern, A et al. (2008) Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron 58 34-41 PubMed GONUTS page
↑ Choe, KM et al. (2006) Liprin-alpha is required for photoreceptor target selection in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 103 11601-6 PubMed GONUTS page
↑ ^12.0 ^12.1 Hofmeyer, K et al. (2006) Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Proc. Natl. Acad. Sci. U.S.A. 103 11595-600 PubMed GONUTS page
↑ Fox, AN & Zinn, K (2005) The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Curr. Biol. 15 1701-11 PubMed GONUTS page
↑ ^14.0 ^14.1 Krueger, NX et al. (2003) Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol. Cell. Biol. 23 6909-21 PubMed GONUTS page
↑ ^15.0 ^15.1 Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page
↑ ^16.0 ^16.1 Krueger, NX et al. (1996) The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell 84 611-22 PubMed GONUTS page
↑ ^17.0 ^17.1 Streuli, M et al. (1989) A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8698-702 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Barlan, K et al. (2017) Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration. Dev. Cell 40 467-477.e5 PubMed GONUTS page
↑ ^19.0 ^19.1 Squarr, AJ et al. (2016) Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J. Cell Biol. 212 591-603 PubMed GONUTS page
↑ Bateman, J & Van Vactor, D (2001) The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance. J. Cell. Sci. 114 1973-80 PubMed GONUTS page

[PMID:21931847-1] 1.0 ^1.1 Madan, LL et al. (2011) Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. PLoS ONE 6 e24766 PubMed GONUTS page

[PMID:25361961-2] Yu, J et al. (2015) Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Hum. Mol. Genet. 24 1493-503 PubMed GONUTS page

[PMID:24174674-3] Cameron, S et al. (2013) Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless. J. Neurosci. 33 17413-21 PubMed GONUTS page

[PMID:21430143-4] 4.0 ^4.1 Weng, YL et al. (2011) The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. J. Neurosci. 31 4421-33 PubMed GONUTS page

[PMID:21084592-5] 5.0 ^5.1 Astigarraga, S et al. (2010) Three Drosophila liprins interact to control synapse formation. J. Neurosci. 30 15358-68 PubMed GONUTS page

[PMID:18516287-6] Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page

[PMID:19889974-7] 7.0 ^7.1 ^7.2 Hofmeyer, K & Treisman, JE (2009) The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism. Proc. Natl. Acad. Sci. U.S.A. 106 19399-404 PubMed GONUTS page

[PMID:19766621-8] 8.0 ^8.1 ^8.2 Prakash, S et al. (2009) Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Dev. Biol. 336 10-9 PubMed GONUTS page

[PMID:18237413-9] Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page

[PMID:18400161-10] Nern, A et al. (2008) Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron 58 34-41 PubMed GONUTS page

[PMID:16864799-11] Choe, KM et al. (2006) Liprin-alpha is required for photoreceptor target selection in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 103 11601-6 PubMed GONUTS page

[PMID:16864797-12] 12.0 ^12.1 Hofmeyer, K et al. (2006) Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Proc. Natl. Acad. Sci. U.S.A. 103 11595-600 PubMed GONUTS page

[PMID:16213816-13] Fox, AN & Zinn, K (2005) The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Curr. Biol. 15 1701-11 PubMed GONUTS page

[PMID:12972609-14] 14.0 ^14.1 Krueger, NX et al. (2003) Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol. Cell. Biol. 23 6909-21 PubMed GONUTS page

[PMID:11178866-15] 15.0 ^15.1 Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page

[PMID:8598047-16] 16.0 ^16.1 Krueger, NX et al. (1996) The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell 84 611-22 PubMed GONUTS page

[PMID:2554325-17] 17.0 ^17.1 Streuli, M et al. (1989) A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8698-702 PubMed GONUTS page

[PMID:28292425-18] 18.0 ^18.1 ^18.2 Barlan, K et al. (2017) Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration. Dev. Cell 40 467-477.e5 PubMed GONUTS page

[PMID:26903538-19] 19.0 ^19.1 Squarr, AJ et al. (2016) Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J. Cell Biol. 212 591-603 PubMed GONUTS page

[PMID:11493634-20] Bateman, J & Van Vactor, D (2001) The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance. J. Cell. Sci. 114 1973-80 PubMed GONUTS page

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DROME:LAR

Contents

Annotations

Notes

References

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