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DROME:LAR

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Lar
Protein Name(s) Tyrosine-protein phosphatase Lar

Protein-tyrosine-phosphate phosphohydrolase dLAR

External Links
UniProt P16621
EMBL M27700
U36857
U36849
U36850
U36851
U36852
U36853
U36854
U36855
U36856
AE014134
AY051985
PIR A36182
RefSeq NP_523604.2
UniGene Dm.24416
PDB 2YD1
3PXJ
PDBsum 2YD1
3PXJ
ProteinModelPortal P16621
SMR P16621
BioGrid 61235
DIP DIP-38648N
IntAct P16621
MINT MINT-8310371
PaxDb P16621
PRIDE P16621
EnsemblMetazoa FBtr0081260
GeneID 35259
KEGG dme:Dmel_CG10443
UCSC CG10443-RA
CTD 104121
FlyBase FBgn0000464
eggNOG COG5599
GeneTree ENSGT00760000118900
InParanoid P16621
KO K05695
OrthoDB EOG7M98FB
PhylomeDB P16621
Reactome REACT_269952
EvolutionaryTrace P16621
GenomeRNAi 35259
NextBio 792660
Proteomes UP000000803
Bgee P16621
ExpressionAtlas P16621
GO GO:0030424
GO:0005925
GO:0016021
GO:0005875
GO:0005886
GO:0008201
GO:0004725
GO:0032093
GO:0005001
GO:0048675
GO:0007411
GO:0007412
GO:0007155
GO:0001700
GO:0008045
GO:0007399
GO:0048477
GO:0035335
GO:0008594
GO:0006470
GO:0045467
GO:0048841
GO:0008360
GO:0031290
GO:0051124
Gene3D 2.60.40.10
3.90.190.10
InterPro IPR003961
IPR007110
IPR013783
IPR013098
IPR003598
IPR029021
IPR000387
IPR016130
IPR000242
Pfam PF00041
PF07679
PF00102
PRINTS PR00700
SMART SM00060
SM00408
SM00194
SUPFAM SSF49265
SSF52799
PROSITE PS50853
PS50835
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004725

protein tyrosine phosphatase activity

PMID:21931847[1]

IDA: Inferred from Direct Assay

F

Figure 2a/b/h/j. Phosphatase activity and substrate recognition features of the different DLAR constructs.

complete
CACAO 1982

GO:0001700

embryonic development via the syncytial blastoderm

PMID:11493634[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:10908587[3]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:21931847[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:2554325[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

PMID:1657402[5]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005001

transmembrane receptor protein tyrosine phosphatase activity

PMID:2554325[4]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005515

protein binding

PMID:10069336[6]

IPI: Inferred from Physical Interaction

UniProtKB:P00522

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10069336[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q8T4F7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11931739[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VM93

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16864797[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VM93

F

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:18433294[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:1657402[5]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:20462449[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:2554325[4]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005925

focal adhesion

PMID:21430143[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:10908587[3]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:2554325[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:14527345[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:25361961[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007399

nervous system development

PMID:12972609[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:11493634[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:18516287[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:19766621[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:19889974[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:8598047[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007412

axon target recognition

PMID:21084592[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:11178866[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0004369
FB:FBgn0004370

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:11178866[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0004370

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:11891122[21]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:16213816[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:8598047[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:9529614[23]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008201

heparin binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:14527345[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008594

photoreceptor cell morphogenesis

PMID:16864797[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016311

dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0030424

axon

PMID:18237413[24]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031290

retinal ganglion cell axon guidance

PMID:16864799[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032093

SAM domain binding

PMID:21084592[19]

IPI: Inferred from Physical Interaction

FB:FBgn0034720

F

Seeded From UniProt

complete

GO:0032093

SAM domain binding

PMID:21430143[11]

IPI: Inferred from Physical Interaction

FB:FBgn0033987

F

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:10908587[3]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:1657402[5]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:21931847[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:2554325[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:2554325[4]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0045467

R7 cell development

PMID:16864797[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045467

R7 cell development

PMID:18400161[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045467

R7 cell development

PMID:19889974[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:12972609[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048675

axon extension

PMID:19766621[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048841

regulation of axon extension involved in axon guidance

PMID:19766621[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051124

synaptic growth at neuromuscular junction

PMID:19889974[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1903386

negative regulation of homophilic cell adhesion

PMID:24174674[27]

IGI: Inferred from Genetic Interaction

FB:FBgn0028482

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Madan, LL et al. (2011) Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. PLoS ONE 6 e24766 PubMed GONUTS page
  2. 2.0 2.1 Bateman, J & Van Vactor, D (2001) The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance. J. Cell. Sci. 114 1973-80 PubMed GONUTS page
  3. 3.0 3.1 3.2 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Streuli, M et al. (1989) A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. U.S.A. 86 8698-702 PubMed GONUTS page
  5. 5.0 5.1 5.2 Tian, SS et al. (1991) Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo. Cell 67 675-85 PubMed GONUTS page
  6. 6.0 6.1 Wills, Z et al. (1999) The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron 22 301-12 PubMed GONUTS page
  7. Kaufmann, N et al. (2002) Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron 34 27-38 PubMed GONUTS page
  8. 8.0 8.1 8.2 Hofmeyer, K et al. (2006) Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Proc. Natl. Acad. Sci. U.S.A. 103 11595-600 PubMed GONUTS page
  9. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  10. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  11. 11.0 11.1 Weng, YL et al. (2011) The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. J. Neurosci. 31 4421-33 PubMed GONUTS page
  12. 12.0 12.1 Kiger, AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2 27 PubMed GONUTS page
  13. Yu, J et al. (2015) Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Hum. Mol. Genet. 24 1493-503 PubMed GONUTS page
  14. 14.0 14.1 Krueger, NX et al. (2003) Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol. Cell. Biol. 23 6909-21 PubMed GONUTS page
  15. Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
  16. 16.0 16.1 16.2 Prakash, S et al. (2009) Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Dev. Biol. 336 10-9 PubMed GONUTS page
  17. 17.0 17.1 17.2 Hofmeyer, K & Treisman, JE (2009) The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism. Proc. Natl. Acad. Sci. U.S.A. 106 19399-404 PubMed GONUTS page
  18. 18.0 18.1 Krueger, NX et al. (1996) The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell 84 611-22 PubMed GONUTS page
  19. 19.0 19.1 Astigarraga, S et al. (2010) Three Drosophila liprins interact to control synapse formation. J. Neurosci. 30 15358-68 PubMed GONUTS page
  20. 20.0 20.1 Sun, Q et al. (2001) Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17 274-91 PubMed GONUTS page
  21. Patel, BN & Van Vactor, DL (2002) Axon guidance: the cytoplasmic tail. Curr. Opin. Cell Biol. 14 221-9 PubMed GONUTS page
  22. Fox, AN & Zinn, K (2005) The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Curr. Biol. 15 1701-11 PubMed GONUTS page
  23. Van Vactor, D et al. (1998) Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Genet. Dev. 8 112-26 PubMed GONUTS page
  24. Jeon, M et al. (2008) Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3 3 PubMed GONUTS page
  25. Choe, KM et al. (2006) Liprin-alpha is required for photoreceptor target selection in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 103 11601-6 PubMed GONUTS page
  26. Nern, A et al. (2008) Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron 58 34-41 PubMed GONUTS page
  27. Cameron, S et al. (2013) Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless. J. Neurosci. 33 17413-21 PubMed GONUTS page