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PMID:16213816
| Citation |
Fox, AN and Zinn, K (2005) The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Curr. Biol. 15:1701-11 |
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| Abstract |
Receptor tyrosine phosphatases (RPTPs) are essential for axon guidance and synaptogenesis in Drosophila. Each guidance decision made by embryonic motor axons during outgrowth to their muscle targets requires a specific subset of the five neural RPTPs. The logic underlying these requirements, however, is still unclear, partially because the ligands recognized by RPTPs at growth cone choice points have not been identified. RPTPs in general are still "orphan receptors" because, while they have been found to interact in vitro with many different proteins, their in vivo ligands are unknown. |
| Links |
PubMed Online version:10.1016/j.cub.2005.08.035 |
| Keywords |
Animals; Cell Line; Crosses, Genetic; Drosophila/genetics; Drosophila/metabolism; Drosophila/physiology; Growth Cones/metabolism; Growth Cones/physiology; Heparan Sulfate Proteoglycans/genetics; Heparan Sulfate Proteoglycans/metabolism; Humans; Immunohistochemistry; Immunoprecipitation; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Nerve Tissue Proteins/metabolism; Protein Binding; Protein Tyrosine Phosphatases/metabolism; Proteoglycans/genetics; Proteoglycans/metabolism; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Receptors, Cell Surface/metabolism; Signal Transduction/genetics; Syndecans |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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