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DROME:HOW

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) how (synonyms: KH93F, qkr93F, stru, who)
Protein Name(s) Protein held out wings

KH domain protein KH93F Protein muscle-specific Protein struthio Protein wings held out Putative RNA-binding protein Quaking-related 93F

External Links
UniProt O01367
EMBL U85651
U72331
AF003106
AF003107
U87150
AE014297
AE014297
AE014297
AY069862
RefSeq NP_001027203.1
NP_001163683.1
NP_001163684.1
NP_524447.2
NP_732695.1
UniGene Dm.20227
ProteinModelPortal O01367
SMR O01367
BioGrid 67557
IntAct O01367
PaxDb O01367
PRIDE O01367
EnsemblMetazoa FBtr0084177
FBtr0301401
GeneID 42596
KEGG dme:Dmel_CG10293
CTD 42596
FlyBase FBgn0264491
eggNOG COG5176
GeneTree ENSGT00550000074434
InParanoid O01367
KO K14945
OMA REHPYQR
PhylomeDB O01367
ChiTaRS how
GenomeRNAi 42596
NextBio 829604
Proteomes UP000000803
Bgee O01367
ExpressionAtlas O01367
GO GO:0005737
GO:0005634
GO:0003730
GO:0003729
GO:0007475
GO:0008366
GO:0007155
GO:0030154
GO:0016477
GO:0030718
GO:0008347
GO:0007498
GO:0008078
GO:0016203
GO:0007521
GO:0007517
GO:0007438
GO:0000381
GO:0008016
GO:0045214
GO:0007525
GO:0007284
Gene3D 3.30.1370.10
InterPro IPR004087
IPR004088
Pfam PF00013
SMART SM00322
SUPFAM SSF54791
PROSITE PS50084

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:15492211[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:17166919[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004087

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004088

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003727

single-stranded RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR031119

F

Seeded From UniProt

complete

GO:0003729

mRNA binding

PMID:17166919[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003729

mRNA binding

PMID:9804767[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003730

mRNA 3'-UTR binding

PMID:17507411[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003730

mRNA 3'-UTR binding

PMID:17728343[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:15492211[1]

IC: Inferred by Curator

GO:0000381

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:22461565[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9169854[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9804767[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:22461565[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006417

regulation of translation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR031119

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:9344542[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007284

spermatogonial cell division

PMID:20362539[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007438

oenocyte development

PMID:17178401[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007475

apposition of dorsal and ventral imaginal disc-derived wing surfaces

PMID:9755209[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007498

mesoderm development

PMID:11486054[12]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

PMID:9118803[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

PMID:9169854[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007521

muscle cell fate determination

PMID:9332381[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007525

somatic muscle development

PMID:9118803[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008016

regulation of heart contraction

PMID:9169854[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008078

mesodermal cell migration

PMID:17728343[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008347

glial cell migration

PMID:17178401[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008366

axon ensheathment

PMID:17178401[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016203

muscle attachment

PMID:9118803[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016477

cell migration

PMID:9118803[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

PMID:12361595[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030718

germ-line stem cell maintenance

PMID:20362539[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045214

sarcomere organization

PMID:20220848[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045995

regulation of embryonic development

PMID:9755209[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Park, JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 15974-9 PubMed GONUTS page
  2. 2.0 2.1 Volohonsky, G et al. (2007) Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA. Development 134 347-56 PubMed GONUTS page
  3. 3.0 3.1 Di Fruscio, M et al. (1998) The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins. J. Biol. Chem. 273 30122-30 PubMed GONUTS page
  4. Israeli, D et al. (2007) Dissection of the target specificity of the RNA-binding protein HOW reveals dpp mRNA as a novel HOW target. Development 134 2107-14 PubMed GONUTS page
  5. 5.0 5.1 Toledano-Katchalski, H et al. (2007) Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Development 134 3473-81 PubMed GONUTS page
  6. 6.0 6.1 Rodrigues, F et al. (2012) The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. Development 139 1765-76 PubMed GONUTS page
  7. 7.0 7.1 7.2 Zaffran, S et al. (1997) The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity. Development 124 2087-98 PubMed GONUTS page
  8. Lo, PC & Frasch, M (1997) A novel KH-domain protein mediates cell adhesion processes in Drosophila. Dev. Biol. 190 241-56 PubMed GONUTS page
  9. 9.0 9.1 Monk, AC et al. (2010) HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. Cell Stem Cell 6 348-60 PubMed GONUTS page
  10. 10.0 10.1 10.2 Edenfeld, G et al. (2006) The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila. Neuron 52 969-80 PubMed GONUTS page
  11. 11.0 11.1 Walsh, EP & Brown, NH (1998) A screen to identify Drosophila genes required for integrin-mediated adhesion. Genetics 150 791-805 PubMed GONUTS page
  12. Furlong, EE et al. (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293 1629-33 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Baehrecke, EH (1997) who encodes a KH RNA binding protein that functions in muscle development. Development 124 1323-32 PubMed GONUTS page
  14. Fyrberg, C et al. (1997) A Drosophila muscle-specific gene related to the mouse quaking locus. Gene 197 315-23 PubMed GONUTS page
  15. Bökel, C & Brown, NH (2002) Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev. Cell 3 311-21 PubMed GONUTS page
  16. Schnorrer, F et al. (2010) Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature 464 287-91 PubMed GONUTS page