DROME:HOW

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	how (synonyms: KH93F, qkr93F, stru, who)
Protein Name(s)	Protein held out wings KH domain protein KH93F Protein muscle-specific Protein struthio Protein wings held out Putative RNA-binding protein Quaking-related 93F
External Links
UniProt	O01367
EMBL	U85651 U72331 AF003106 AF003107 U87150 AE014297 AE014297 AE014297 AY069862
RefSeq	NP_001027203.1 NP_001163683.1 NP_001163684.1 NP_524447.2 NP_732695.1
UniGene	Dm.20227
ProteinModelPortal	O01367
SMR	O01367
BioGrid	67557
IntAct	O01367
PaxDb	O01367
PRIDE	O01367
EnsemblMetazoa	FBtr0084177 FBtr0301401
GeneID	42596
KEGG	dme:Dmel_CG10293
CTD	42596
FlyBase	FBgn0264491
eggNOG	COG5176
GeneTree	ENSGT00550000074434
InParanoid	O01367
KO	K14945
OMA	REHPYQR
PhylomeDB	O01367
ChiTaRS	how
GenomeRNAi	42596
NextBio	829604
Proteomes	UP000000803
Bgee	O01367
ExpressionAtlas	O01367
GO	GO:0005737 GO:0005634 GO:0003730 GO:0003729 GO:0007475 GO:0008366 GO:0007155 GO:0030154 GO:0016477 GO:0030718 GO:0008347 GO:0007498 GO:0008078 GO:0016203 GO:0007521 GO:0007517 GO:0007438 GO:0000381 GO:0008016 GO:0045214 GO:0007525 GO:0007284
Gene3D	3.30.1370.10
InterPro	IPR004087 IPR004088
Pfam	PF00013
SMART	SM00322
SUPFAM	SSF54791
PROSITE	PS50084

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0016477	cell migration	PMID:9118803^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016203	muscle attachment	PMID:9118803^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	PMID:9169854^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007521	muscle cell fate determination	PMID:9332381^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	PMID:9169854^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007517	muscle organ development	PMID:9118803^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:9344542^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9169854^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:17507411^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007438	oenocyte development	PMID:17178401^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008366	axon ensheathment	PMID:17178401^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22461565^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22461565^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030718	germ-line stem cell population maintenance	PMID:20362539^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007284	spermatogonial cell division	PMID:20362539^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045214	sarcomere organization	PMID:20220848^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008078	mesodermal cell migration	PMID:17728343^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:17728343^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008347	glial cell migration	PMID:17178401^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:17166919^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:17166919^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:15492211^[12]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15492211^[12]	ECO:0000305	curator inference used in manual assertion	GO:0000381	C	Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:11486054^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:9804767^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9804767^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007475	apposition of dorsal and ventral imaginal disc-derived wing surfaces	PMID:9755209^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	PMID:9755209^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007525	somatic muscle development	PMID:9118803^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004087	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004088 InterPro:IPR036612	F	Seeded From UniProt	complete
enables	GO:0003727	single-stranded RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031119	F	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031119	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:12361595^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Baehrecke, EH (1997) who encodes a KH RNA binding protein that functions in muscle development. Development 124 1323-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zaffran, S et al. (1997) The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity. Development 124 2087-98 PubMed GONUTS page
↑ Fyrberg, C et al. (1997) A Drosophila muscle-specific gene related to the mouse quaking locus. Gene 197 315-23 PubMed GONUTS page
↑ Lo, PC & Frasch, M (1997) A novel KH-domain protein mediates cell adhesion processes in Drosophila. Dev. Biol. 190 241-56 PubMed GONUTS page
↑ Israeli, D et al. (2007) Dissection of the target specificity of the RNA-binding protein HOW reveals dpp mRNA as a novel HOW target. Development 134 2107-14 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Edenfeld, G et al. (2006) The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila. Neuron 52 969-80 PubMed GONUTS page
↑ ^7.0 ^7.1 Rodrigues, F et al. (2012) The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. Development 139 1765-76 PubMed GONUTS page
↑ ^8.0 ^8.1 Monk, AC et al. (2010) HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. Cell Stem Cell 6 348-60 PubMed GONUTS page
↑ Schnorrer, F et al. (2010) Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature 464 287-91 PubMed GONUTS page
↑ ^10.0 ^10.1 Toledano-Katchalski, H et al. (2007) Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Development 134 3473-81 PubMed GONUTS page
↑ ^11.0 ^11.1 Volohonsky, G et al. (2007) Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA. Development 134 347-56 PubMed GONUTS page
↑ ^12.0 ^12.1 Park, JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 15974-9 PubMed GONUTS page
↑ Furlong, EE et al. (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293 1629-33 PubMed GONUTS page
↑ ^14.0 ^14.1 Di Fruscio, M et al. (1998) The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins. J. Biol. Chem. 273 30122-30 PubMed GONUTS page
↑ ^15.0 ^15.1 Walsh, EP & Brown, NH (1998) A screen to identify Drosophila genes required for integrin-mediated adhesion. Genetics 150 791-805 PubMed GONUTS page
↑ Bökel, C & Brown, NH (2002) Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev. Cell 3 311-21 PubMed GONUTS page

[PMID:9118803-1] 1.0 ^1.1 ^1.2 ^1.3 Baehrecke, EH (1997) who encodes a KH RNA binding protein that functions in muscle development. Development 124 1323-32 PubMed GONUTS page

[PMID:9169854-2] 2.0 ^2.1 ^2.2 Zaffran, S et al. (1997) The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity. Development 124 2087-98 PubMed GONUTS page

[PMID:9332381-3] Fyrberg, C et al. (1997) A Drosophila muscle-specific gene related to the mouse quaking locus. Gene 197 315-23 PubMed GONUTS page

[PMID:9344542-4] Lo, PC & Frasch, M (1997) A novel KH-domain protein mediates cell adhesion processes in Drosophila. Dev. Biol. 190 241-56 PubMed GONUTS page

[PMID:17507411-5] Israeli, D et al. (2007) Dissection of the target specificity of the RNA-binding protein HOW reveals dpp mRNA as a novel HOW target. Development 134 2107-14 PubMed GONUTS page

[PMID:17178401-6] 6.0 ^6.1 ^6.2 Edenfeld, G et al. (2006) The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila. Neuron 52 969-80 PubMed GONUTS page

[PMID:22461565-7] 7.0 ^7.1 Rodrigues, F et al. (2012) The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. Development 139 1765-76 PubMed GONUTS page

[PMID:20362539-8] 8.0 ^8.1 Monk, AC et al. (2010) HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. Cell Stem Cell 6 348-60 PubMed GONUTS page

[PMID:20220848-9] Schnorrer, F et al. (2010) Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature 464 287-91 PubMed GONUTS page

[PMID:17728343-10] 10.0 ^10.1 Toledano-Katchalski, H et al. (2007) Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Development 134 3473-81 PubMed GONUTS page

[PMID:17166919-11] 11.0 ^11.1 Volohonsky, G et al. (2007) Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA. Development 134 347-56 PubMed GONUTS page

[PMID:15492211-12] 12.0 ^12.1 Park, JW et al. (2004) Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 101 15974-9 PubMed GONUTS page

[PMID:11486054-13] Furlong, EE et al. (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293 1629-33 PubMed GONUTS page

[PMID:9804767-14] 14.0 ^14.1 Di Fruscio, M et al. (1998) The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins. J. Biol. Chem. 273 30122-30 PubMed GONUTS page

[PMID:9755209-15] 15.0 ^15.1 Walsh, EP & Brown, NH (1998) A screen to identify Drosophila genes required for integrin-mediated adhesion. Genetics 150 791-805 PubMed GONUTS page

[PMID:12361595-16] Bökel, C & Brown, NH (2002) Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev. Cell 3 311-21 PubMed GONUTS page

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DROME:HOW

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