PMID:11486054

Citation	Furlong, EE, Andersen, EC, Null, B, White, KP and Scott, MP (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293:1629-33
Abstract	The transcription factor Twist initiates Drosophila mesoderm development, resulting in the formation of heart, somatic muscle, and other cell types. Using a Drosophila embryo sorter, we isolated enough homozygous twist mutant embryos to perform DNA microarray experiments. Transcription profiles of twist loss-of-function embryos, embryos with ubiquitous twist expression, and wild-type embryos were compared at different developmental stages. The results implicate hundreds of genes, many with vertebrate homologs, in stage-specific processes in mesoderm development. One such gene, gleeful, related to the vertebrate Gli genes, is essential for somatic muscle development and sufficient to cause neural cells to express a muscle marker.
Links	PubMed Online version:10.1126/science.1062660
Keywords	Animals; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Ectoderm/cytology; Embryo, Nonmammalian/metabolism; Embryonic Development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; In Situ Hybridization; Insect Proteins/genetics; Membrane Glycoproteins/genetics; Mesoderm/cytology; Mesoderm/metabolism; Mutation; Nuclear Proteins/genetics; Nuclear Proteins/physiology; Oligonucleotide Array Sequence Analysis; Receptors, Cell Surface; Toll-Like Receptors; Transcription Factors; Transcription, Genetic; Twist Transcription Factor
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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