DROME:CCNE

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	CycE
Protein Name(s)	G1/S-specific cyclin-E DmCycE
External Links
UniProt	P54733
EMBL	X75026 X75027 AE014134 AE014134 AY069507 AY061233
PIR	S41755 S41756
RefSeq	NP_476959.1 NP_476960.1 NP_723924.1 NP_723925.1 NP_723926.1
UniGene	Dm.3509
ProteinModelPortal	P54733
SMR	P54733
BioGrid	60939
DIP	DIP-18331N
IntAct	P54733
MINT	MINT-300447
PaxDb	P54733
EnsemblMetazoa	FBtr0080773 FBtr0080774 FBtr0080775 FBtr0080776
GeneID	34924
KEGG	dme:Dmel_CG3938
CTD	34924
FlyBase	FBgn0010382
eggNOG	COG5024
GeneTree	ENSGT00760000118939
InParanoid	P54733
KO	K06626
OrthoDB	EOG7HB595
PhylomeDB	P54733
Reactome	REACT_180285 REACT_180658 REACT_209388 REACT_234707
SignaLink	P54733
GenomeRNAi	34924
NextBio	790902
Proteomes	UP000000803
Bgee	P54733
ExpressionAtlas	P54733
GO	GO:0005634 GO:0016538 GO:0007155 GO:0009987 GO:0006974 GO:0007307 GO:0000082 GO:0007259 GO:0000278 GO:0060564 GO:0007400 GO:0048665 GO:0048477 GO:0007422 GO:0007277 GO:0043065 GO:0042127 GO:0008360 GO:0006275 GO:0007096 GO:0044719 GO:0045859 GO:0001932 GO:0045035 GO:0035019
Gene3D	1.10.472.10
InterPro	IPR013763 IPR004367 IPR006671
Pfam	PF02984 PF00134
SMART	SM00385
SUPFAM	SSF47954
PROSITE	PS00292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007422	peripheral nervous system development	PMID:8187637^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007277	pole cell development	PMID:8187637^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8187637^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:8187637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88302 PANTHER:PTN000019791	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108069 MGI:MGI:88313 MGI:MGI:88315 MGI:MGI:88316 PANTHER:PTN000019791 RGD:1307783 RGD:2291 RGD:2293 RGD:2294 RGD:621083 RGD:68384 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P30279 UniProtKB:P30281	F	Seeded From UniProt	complete
enables	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000175354 FB:FBgn0000404 FB:FBgn0000405 FB:FBgn0010315 FB:FBgn0010317 FB:FBgn0010382 MGI:MGI:1329034 MGI:MGI:88313 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPBC19F5.01c SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000003341 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 WB:WBGene00000865 WB:WBGene00000868 WB:WBGene00000871	F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000019791 RGD:2293 RGD:621083 RGD:68384 UniProtKB:P30279 WB:WBGene00000871	P	Seeded From UniProt	complete
involved_in	GO:0007129	synapsis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1329034 MGI:MGI:88316 PANTHER:PTN000808611	P	Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 PANTHER:PTN000019791 WB:WBGene00000871	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002468700 RGD:2294 UniProtKB:O95067 UniProtKB:P14635	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 MGI:MGI:108069 MGI:MGI:2145534 MGI:MGI:88302 MGI:MGI:88313 MGI:MGI:88314 MGI:MGI:88315 PANTHER:PTN000019791 PomBase:SPBC582.03 RGD:2291 RGD:2294 RGD:68384 SGD:S000002314 SGD:S000003340 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 TAIR:locus:2031407 TAIR:locus:2142504 TAIR:locus:2160722 TAIR:locus:2205871 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P22674 UniProtKB:Q9C6A9 WB:WBGene00000865 WB:WBGene00000868	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 FB:FBgn0000405 FB:FBgn0010382 FB:FBgn0015625 MGI:MGI:108069 MGI:MGI:88302 MGI:MGI:88313 MGI:MGI:88314 MGI:MGI:88315 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPBC582.03 RGD:2291 RGD:2294 RGD:2295 RGD:621059 RGD:68384 SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 TAIR:locus:2031407 TAIR:locus:2034250 TAIR:locus:2120081 TAIR:locus:2124331 TAIR:locus:2142504 TAIR:locus:2196563 TAIR:locus:2205871 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P24864 UniProtKB:P30279 UniProtKB:P41002 UniProtKB:Q9C6A9 WB:WBGene00000865 WB:WBGene00000868 WB:WBGene00000871	C	Seeded From UniProt	complete
contributes_to	GO:0004672	protein kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88313 PANTHER:PTN000019791	F	Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88313 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPAPB2B4.03 SGD:S000003340 SGD:S000006177 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P30279 UniProtKB:P30281 UniProtKB:P43449	C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 FB:FBgn0010317 FB:FBgn0015625 PANTHER:PTN000019791 RGD:2291 UniProtKB:P22674 WB:WBGene00000865 WB:WBGene00000868	P	Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000175354 CGD:CAL0000185532 PANTHER:PTN000019791 SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000003341 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 UniProtKB:Q59YH3	P	Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:26092715^[3]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044719	regulation of imaginal disc-derived wing size	PMID:23232763^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	PMID:19914234^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	PMID:19914234^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19966222^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006275	regulation of DNA replication	PMID:17940024^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007096	regulation of exit from mitosis	PMID:16854973^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000404	P	Seeded From UniProt	complete
involved_in	GO:0007096	regulation of exit from mitosis	PMID:16854973^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0262699	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:16949821^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17055987^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:17055987^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045035	sensory organ precursor cell division	PMID:15829522^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007400	neuroblast fate determination	PMID:15580266^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:12586062^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004864	P	Seeded From UniProt	complete
involved_in	GO:1904667	negative regulation of ubiquitin protein ligase activity	PMID:11782312^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0017551	P	Seeded From UniProt	complete
involved_in	GO:0035736	cell proliferation involved in compound eye morphogenesis	PMID:9691043^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:9691043^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007307	eggshell chorion gene amplification	PMID:9499407^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:8675008^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	PMID:7588070^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090210	regulation of establishment of blood-brain barrier	PMID:28265104^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004367	C	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:14616073^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Richardson, HE et al. (1993) A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis. Development 119 673-90 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bivik, C et al. (2015) Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells. Genetics 200 1229-44 PubMed GONUTS page
↑ Djiane, A et al. (2013) Dissecting the mechanisms of Notch induced hyperplasia. EMBO J. 32 60-71 PubMed GONUTS page
↑ ^5.0 ^5.1 Berger, C et al. (2010) Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev. Biol. 337 415-24 PubMed GONUTS page
↑ Wang, ZA & Kalderon, D (2009) Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Proc. Natl. Acad. Sci. U.S.A. 106 21701-6 PubMed GONUTS page
↑ Park, EA et al. (2007) Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. Proc. Natl. Acad. Sci. U.S.A. 104 16739-46 PubMed GONUTS page
↑ ^8.0 ^8.1 Reber, A et al. (2006) Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133 3201-11 PubMed GONUTS page
↑ Nolo, R et al. (2006) The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr. Biol. 16 1895-904 PubMed GONUTS page
↑ ^10.0 ^10.1 Parker, J (2006) Control of compartment size by an EGF ligand from neighboring cells. Curr. Biol. 16 2058-65 PubMed GONUTS page
↑ Audibert, A et al. (2005) Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. Development 132 2287-97 PubMed GONUTS page
↑ Berger, C et al. (2005) A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7 56-62 PubMed GONUTS page
↑ Chen, X et al. (2003) Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev. Cell 4 179-90 PubMed GONUTS page
↑ Grosskortenhaus, R & Sprenger, F (2002) Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev. Cell 2 29-40 PubMed GONUTS page
↑ ^15.0 ^15.1 Secombe, J et al. (1998) Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics 149 1867-82 PubMed GONUTS page
↑ Calvi, BR et al. (1998) Cell cycle control of chorion gene amplification. Genes Dev. 12 734-44 PubMed GONUTS page
↑ Du, W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 1206-18 PubMed GONUTS page
↑ Richardson, H et al. (1995) Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 121 3371-9 PubMed GONUTS page
↑ Li, D et al. (2017) Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in . Proc. Natl. Acad. Sci. U.S.A. 114 E2365-E2374 PubMed GONUTS page
↑ Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page

[PMID:8187637-1] 1.0 ^1.1 ^1.2 ^1.3 Richardson, HE et al. (1993) A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis. Development 119 673-90 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26092715-3] Bivik, C et al. (2015) Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells. Genetics 200 1229-44 PubMed GONUTS page

[PMID:23232763-4] Djiane, A et al. (2013) Dissecting the mechanisms of Notch induced hyperplasia. EMBO J. 32 60-71 PubMed GONUTS page

[PMID:19914234-5] 5.0 ^5.1 Berger, C et al. (2010) Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev. Biol. 337 415-24 PubMed GONUTS page

[PMID:19966222-6] Wang, ZA & Kalderon, D (2009) Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Proc. Natl. Acad. Sci. U.S.A. 106 21701-6 PubMed GONUTS page

[PMID:17940024-7] Park, EA et al. (2007) Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. Proc. Natl. Acad. Sci. U.S.A. 104 16739-46 PubMed GONUTS page

[PMID:16854973-8] 8.0 ^8.1 Reber, A et al. (2006) Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133 3201-11 PubMed GONUTS page

[PMID:16949821-9] Nolo, R et al. (2006) The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr. Biol. 16 1895-904 PubMed GONUTS page

[PMID:17055987-10] 10.0 ^10.1 Parker, J (2006) Control of compartment size by an EGF ligand from neighboring cells. Curr. Biol. 16 2058-65 PubMed GONUTS page

[PMID:15829522-11] Audibert, A et al. (2005) Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. Development 132 2287-97 PubMed GONUTS page

[PMID:15580266-12] Berger, C et al. (2005) A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7 56-62 PubMed GONUTS page

[PMID:12586062-13] Chen, X et al. (2003) Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev. Cell 4 179-90 PubMed GONUTS page

[PMID:11782312-14] Grosskortenhaus, R & Sprenger, F (2002) Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev. Cell 2 29-40 PubMed GONUTS page

[PMID:9691043-15] 15.0 ^15.1 Secombe, J et al. (1998) Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics 149 1867-82 PubMed GONUTS page

[PMID:9499407-16] Calvi, BR et al. (1998) Cell cycle control of chorion gene amplification. Genes Dev. 12 734-44 PubMed GONUTS page

[PMID:8675008-17] Du, W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 1206-18 PubMed GONUTS page

[PMID:7588070-18] Richardson, H et al. (1995) Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 121 3371-9 PubMed GONUTS page

[PMID:28265104-19] Li, D et al. (2017) Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in . Proc. Natl. Acad. Sci. U.S.A. 114 E2365-E2374 PubMed GONUTS page

[PMID:14616073-20] Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page

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DROME:CCNE

Contents

Annotations

Notes

References

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