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DROME:CCNE

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) CycE
Protein Name(s) G1/S-specific cyclin-E

DmCycE

External Links
UniProt P54733
EMBL X75026
X75027
AE014134
AE014134
AY069507
AY061233
PIR S41755
S41756
RefSeq NP_476959.1
NP_476960.1
NP_723924.1
NP_723925.1
NP_723926.1
UniGene Dm.3509
ProteinModelPortal P54733
SMR P54733
BioGrid 60939
DIP DIP-18331N
IntAct P54733
MINT MINT-300447
PaxDb P54733
EnsemblMetazoa FBtr0080773
FBtr0080774
FBtr0080775
FBtr0080776
GeneID 34924
KEGG dme:Dmel_CG3938
CTD 34924
FlyBase FBgn0010382
eggNOG COG5024
GeneTree ENSGT00760000118939
InParanoid P54733
KO K06626
OrthoDB EOG7HB595
PhylomeDB P54733
Reactome REACT_180285
REACT_180658
REACT_209388
REACT_234707
SignaLink P54733
GenomeRNAi 34924
NextBio 790902
Proteomes UP000000803
Bgee P54733
ExpressionAtlas P54733
GO GO:0005634
GO:0016538
GO:0007155
GO:0009987
GO:0006974
GO:0007307
GO:0000082
GO:0007259
GO:0000278
GO:0060564
GO:0007400
GO:0048665
GO:0048477
GO:0007422
GO:0007277
GO:0043065
GO:0042127
GO:0008360
GO:0006275
GO:0007096
GO:0044719
GO:0045859
GO:0001932
GO:0045035
GO:0035019
Gene3D 1.10.472.10
InterPro IPR013763
IPR004367
IPR006671
Pfam PF02984
PF00134
SMART SM00385
SUPFAM SSF47954
PROSITE PS00292

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000082

G1/S transition of mitotic cell cycle

PMID:11102367[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0000082

G1/S transition of mitotic cell cycle

PMID:14616073[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0000082

G1/S transition of mitotic cell cycle

PMID:17055987[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000082

G1/S transition of mitotic cell cycle

PMID:8187637[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000278

mitotic cell cycle

PMID:14527345[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001932

regulation of protein phosphorylation

PMID:8675008[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12093739[7]

IPI: Inferred from Physical Interaction

FB:FBgn0000212

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12093739[7]

IPI: Inferred from Physical Interaction

FB:FBgn0011715

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15575970[8]

IPI: Inferred from Physical Interaction

UniProtKB:P23572

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16603075[9]

IPI: Inferred from Physical Interaction

UniProtKB:P23572

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17431409[10]

IPI: Inferred from Physical Interaction

UniProtKB:P22469

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17431409[10]

IPI: Inferred from Physical Interaction

UniProtKB:P23572

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:7809159[11]

IPI: Inferred from Physical Interaction

UniProtKB:P23572

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004367

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:19966222[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:8187637[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006275

regulation of DNA replication

PMID:17940024[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:19543366[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007096

regulation of exit from mitosis

PMID:16854973[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0000404

P

Seeded From UniProt

complete

GO:0007096

regulation of exit from mitosis

PMID:16854973[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0262699

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:14527345[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007259

JAK-STAT cascade

PMID:12586062[16]

IGI: Inferred from Genetic Interaction

FB:FBgn0004864

P

Seeded From UniProt

complete

GO:0007277

pole cell development

PMID:8187637[4]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007307

eggshell chorion gene amplification

PMID:9499407[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007400

neuroblast fate determination

PMID:15580266[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007422

peripheral nervous system development

PMID:11102367[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007422

peripheral nervous system development

PMID:8187637[4]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:14527345[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016538

cyclin-dependent protein serine/threonine kinase regulator activity

PMID:10471707[19]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0016538

cyclin-dependent protein serine/threonine kinase regulator activity

PMID:7588070[20]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0035019

somatic stem cell maintenance

PMID:19914234[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035736

cell proliferation involved in compound eye morphogenesis

PMID:9691043[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:16949821[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

PMID:17055987[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0044719

regulation of imaginal disc-derived wing size

PMID:23232763[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045035

sensory organ precursor cell division

PMID:15829522[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045859

regulation of protein kinase activity

PMID:10471707[19]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0045859

regulation of protein kinase activity

PMID:7588070[20]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:11131529[26]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048665

neuron fate specification

PMID:19914234[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

GO:0060564

negative regulation of APC-Cdc20 complex activity

PMID:11782312[27]

IGI: Inferred from Genetic Interaction

FB:FBgn0017551

P

Seeded From UniProt

complete

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

PMID:9691043[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Prokopenko, SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156 1691-715 PubMed GONUTS page
  2. Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page
  3. 3.0 3.1 Parker, J (2006) Control of compartment size by an EGF ligand from neighboring cells. Curr. Biol. 16 2058-65 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Richardson, HE et al. (1993) A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis. Development 119 673-90 PubMed GONUTS page
  5. 5.0 5.1 5.2 Kiger, AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2 27 PubMed GONUTS page
  6. Du, W et al. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10 1206-18 PubMed GONUTS page
  7. 7.0 7.1 Brumby, AM et al. (2002) Drosophila cyclin E interacts with components of the Brahma complex. EMBO J. 21 3377-89 PubMed GONUTS page
  8. Stanyon, CA et al. (2004) A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol. 5 R96 PubMed GONUTS page
  9. Pacifico, S et al. (2006) A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics 7 195 PubMed GONUTS page
  10. 10.0 10.1 Gawliński, P et al. (2007) The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins. EMBO Rep. 8 490-6 PubMed GONUTS page
  11. Finley, RL Jr & Brent, R (1994) Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Proc. Natl. Acad. Sci. U.S.A. 91 12980-4 PubMed GONUTS page
  12. Wang, ZA & Kalderon, D (2009) Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Proc. Natl. Acad. Sci. U.S.A. 106 21701-6 PubMed GONUTS page
  13. Park, EA et al. (2007) Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. Proc. Natl. Acad. Sci. U.S.A. 104 16739-46 PubMed GONUTS page
  14. Ravi, D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 5 e1000527 PubMed GONUTS page
  15. 15.0 15.1 Reber, A et al. (2006) Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133 3201-11 PubMed GONUTS page
  16. Chen, X et al. (2003) Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev. Cell 4 179-90 PubMed GONUTS page
  17. Calvi, BR et al. (1998) Cell cycle control of chorion gene amplification. Genes Dev. 12 734-44 PubMed GONUTS page
  18. Berger, C et al. (2005) A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7 56-62 PubMed GONUTS page
  19. 19.0 19.1 Ashburner, M et al. (1999) An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics 153 179-219 PubMed GONUTS page
  20. 20.0 20.1 Richardson, H et al. (1995) Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 121 3371-9 PubMed GONUTS page
  21. 21.0 21.1 Berger, C et al. (2010) Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Dev. Biol. 337 415-24 PubMed GONUTS page
  22. 22.0 22.1 Secombe, J et al. (1998) Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Genetics 149 1867-82 PubMed GONUTS page
  23. Nolo, R et al. (2006) The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr. Biol. 16 1895-904 PubMed GONUTS page
  24. Djiane, A et al. (2013) Dissecting the mechanisms of Notch induced hyperplasia. EMBO J. 32 60-71 PubMed GONUTS page
  25. Audibert, A et al. (2005) Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. Development 132 2287-97 PubMed GONUTS page
  26. Deng, W & Lin, H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int. Rev. Cytol. 203 93-138 PubMed GONUTS page
  27. Grosskortenhaus, R & Sprenger, F (2002) Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev. Cell 2 29-40 PubMed GONUTS page