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PMID:12586062
| Citation |
Chen, X, Oh, SW, Zheng, Z, Chen, HW, Shin, HH and Hou, SX (2003) Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev. Cell 4:179-90 |
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| Abstract |
The JAK/STAT signal transduction pathway regulates many developmental processes in Drosophila. However, the functional mechanism of this pathway is poorly understood. In this report, we identify the Drosophila cyclin-dependent kinase 4 (Cdk4), which exhibits embryonic mutant phenotypes identical to those in the Hopscotch/JAK kinase and stat92E/STAT mutations. Specific genetic interactions between Cdk4 and hop mutations suggest that Cdk4 functions downstream of the HOP tyrosine kinase. We further show that Cyclin D-Cdk4 (as well as Cyclin E-Cdk2) binds and regulates STAT92E protein stability. STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development. |
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| Keywords |
Animals; Animals, Genetically Modified; Body Patterning/genetics; CDC2-CDC28 Kinases; Cell Differentiation; Cell Polarity; Crosses, Genetic; Cyclin D; Cyclin E/genetics; Cyclin E/metabolism; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases/genetics; Cyclin-Dependent Kinases/metabolism; Cyclins/genetics; Cyclins/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila Proteins/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Embryo, Nonmammalian/physiology; Enzyme Activation; Eye/cytology; Eye/embryology; Female; Gene Expression Regulation, Developmental; Glycoproteins/metabolism; In Situ Hybridization; Insect Proteins/metabolism; Janus Kinase 1; Janus Kinases; Mutation; Oogenesis/physiology; Ovarian Follicle/cytology; Ovarian Follicle/physiology; Phenotype; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins; STAT Transcription Factors; Signal Transduction; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription Factors |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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