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DANRE:YAP1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) yap1
Protein Name(s) Transcriptional coactivator YAP1

Yes-associated protein 1 zYAP (ECO:0000303 with PMID:21687713[1]) Protein yorkie homolog Yes-associated protein YAP65 homolog

External Links
UniProt Q1L8J7
EMBL CR762425
CT573116
BC129216
RefSeq NP_001132952.1
UniGene Dr.119226
Dr.75317
ProteinModelPortal Q1L8J7
SMR Q1L8J7
STRING 7955.ENSDARP00000089684
PaxDb Q1L8J7
Ensembl ENSDART00000098914
GeneID 561411
KEGG dre:561411
CTD 10413
ZFIN ZDB-GENE-030131-9710
eggNOG KOG0940
COG5021
GeneTree ENSGT00510000046760
HOGENOM HOG000007854
HOVERGEN HBG002748
KO K16687
OMA MDPGQQP
OrthoDB EOG75MVW6
PhylomeDB Q1L8J7
TreeFam TF326941
Reactome [www.reactome.org/content/detail/R-DRE-1251985 R-DRE-1251985]
[www.reactome.org/content/detail/R-DRE-2028269 R-DRE-2028269]
[www.reactome.org/content/detail/R-DRE-2032785 R-DRE-2032785]
PRO PR:Q1L8J7
Proteomes UP000000437
GO GO:0005737
GO:0005634
GO:0007420
GO:0051216
GO:0042384
GO:0009950
GO:0035162
GO:0007492
GO:0060914
GO:0043066
GO:0010629
GO:0031016
GO:0048916
GO:0039022
GO:0006355
GO:0003406
GO:0006351
InterPro IPR001202
Pfam PF00397
SMART SM00456
SUPFAM SSF51045
PROSITE PS01159
PS50020

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0035162

embryonic hemopoiesis

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

P

Figure 8, yap knockdowns have delayed maturation of red blood cells.

complete
CACAO 7060

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0060914

heart formation

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

P

Figure 7, yap knockdowns show delay in cardiogenesis.

complete
CACAO 7061

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0009950

dorsal/ventral axis specification

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

P

Figure 5, yap knockdown leads to reduced dorsoventral marker expression.

complete
CACAO 7062

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0010629

negative regulation of gene expression

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

P

Figure 6, yap knockdowns have increased expression of myoD.

complete
CACAO 7063

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0043066

negative regulation of apoptotic process

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

P

Figure 4, yap knockdowns show increased cell death

complete
CACAO 7064

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

GO:0009950

dorsal/ventral axis specification

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0010629

negative regulation of gene expression

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0035162

embryonic hemopoiesis

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0043066

negative regulation of apoptotic process

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0060914

heart formation

PMID:23494967[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gee, ST et al. (2011) Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS ONE 6 e20309 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Hu, J et al. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int. J. Biol. Sci. 9 267-78 PubMed GONUTS page