DANRE:YAP1

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	yap1
Protein Name(s)	Transcriptional coactivator YAP1 Yes-associated protein 1 zYAP (ECO:0000303 with PMID:21687713^[1]) Protein yorkie homolog Yes-associated protein YAP65 homolog
External Links
UniProt	Q1L8J7
EMBL	CR762425 CT573116 BC129216
RefSeq	NP_001132952.1
UniGene	Dr.119226 Dr.75317
ProteinModelPortal	Q1L8J7
SMR	Q1L8J7
STRING	7955.ENSDARP00000089684
PaxDb	Q1L8J7
Ensembl	ENSDART00000098914
GeneID	561411
KEGG	dre:561411
CTD	10413
ZFIN	ZDB-GENE-030131-9710
eggNOG	KOG0940 COG5021
GeneTree	ENSGT00510000046760
HOGENOM	HOG000007854
HOVERGEN	HBG002748
KO	K16687
OMA	MDPGQQP
OrthoDB	EOG75MVW6
PhylomeDB	Q1L8J7
TreeFam	TF326941
Reactome	[www.reactome.org/content/detail/R-DRE-1251985 R-DRE-1251985] [www.reactome.org/content/detail/R-DRE-2028269 R-DRE-2028269] [www.reactome.org/content/detail/R-DRE-2032785 R-DRE-2032785]
PRO	PR:Q1L8J7
Proteomes	UP000000437
GO	GO:0005737 GO:0005634 GO:0007420 GO:0051216 GO:0042384 GO:0009950 GO:0035162 GO:0007492 GO:0060914 GO:0043066 GO:0010629 GO:0031016 GO:0048916 GO:0039022 GO:0006355 GO:0003406 GO:0006351
InterPro	IPR001202
Pfam	PF00397
SMART	SM00456
SUPFAM	SSF51045
PROSITE	PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0035162	embryonic hemopoiesis	PMID:23494967^[2]	ECO:0000315			P	Figure 8, yap knockdowns have delayed maturation of red blood cells.	complete CACAO 7060
	GO:0060914	heart formation	PMID:23494967^[2]	ECO:0000315			P	Figure 7, yap knockdowns show delay in cardiogenesis.	complete CACAO 7061
	GO:0009950	dorsal/ventral axis specification	PMID:23494967^[2]	ECO:0000315			P	Figure 5, yap knockdown leads to reduced dorsoventral marker expression.	complete CACAO 7062
	GO:0010629	negative regulation of gene expression	PMID:23494967^[2]	ECO:0000315			P	Figure 6, yap knockdowns have increased expression of myoD.	complete CACAO 7063
	GO:0043066	negative regulation of apoptotic process	PMID:23494967^[2]	ECO:0000315			P	Figure 4, yap knockdowns show increased cell death	complete CACAO 7064
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:23494967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23494967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	PMID:23494967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060914	heart formation	PMID:23494967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	PMID:23494967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1905480	positive regulation of glutamate-ammonia ligase activity	PMID:27428308^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-161027-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:26157348^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:19393221^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
involved_in	GO:0048916	posterior lateral line development	PMID:24598795^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-140915-6	P	Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	PMID:28350986^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-170615-6	P	Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	PMID:27428308^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-161027-2	P	Seeded From UniProt	complete
involved_in	GO:0039022	pronephric duct development	PMID:26157348^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:26209644^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160901-9	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:26209644^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160901-10	P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:25915126^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090609-10	P	Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	PMID:25313964^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090609-10	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:19393221^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19439659^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:26209646^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-160122-4	P	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:26209646^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160122-9	P	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:26209646^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160122-3	P	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:27428308^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gee, ST et al. (2011) Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS ONE 6 e20309 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Hu, J et al. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int. J. Biol. Sci. 9 267-78 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Cox, AG et al. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat. Cell Biol. 18 886-896 PubMed GONUTS page
↑ ^4.0 ^4.1 He, L et al. (2015) Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int. J. Biol. Sci. 11 935-47 PubMed GONUTS page
↑ ^5.0 ^5.1 Jiang, Q et al. (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem. Biophys. Res. Commun. 384 114-9 PubMed GONUTS page
↑ Loh, SL et al. (2014) Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep 4 4289 PubMed GONUTS page
↑ Nakajima, H et al. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev. Cell 40 523-536.e6 PubMed GONUTS page
↑ ^8.0 ^8.1 Mateus, R et al. (2015) Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development 142 2752-63 PubMed GONUTS page
↑ Cebola, I et al. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat. Cell Biol. 17 615-626 PubMed GONUTS page
↑ Fukui, H et al. (2014) S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev. Cell 31 128-36 PubMed GONUTS page
↑ Skouloudaki, K et al. (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc. Natl. Acad. Sci. U.S.A. 106 8579-84 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Miesfeld, JB et al. (2015) Yap and Taz regulate retinal pigment epithelial cell fate. Development 142 3021-32 PubMed GONUTS page

[PMID:21687713-1] Gee, ST et al. (2011) Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS ONE 6 e20309 PubMed GONUTS page

[PMID:23494967-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Hu, J et al. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int. J. Biol. Sci. 9 267-78 PubMed GONUTS page

[PMID:27428308-3] 3.0 ^3.1 ^3.2 Cox, AG et al. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat. Cell Biol. 18 886-896 PubMed GONUTS page

[PMID:26157348-4] 4.0 ^4.1 He, L et al. (2015) Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int. J. Biol. Sci. 11 935-47 PubMed GONUTS page

[PMID:19393221-5] 5.0 ^5.1 Jiang, Q et al. (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem. Biophys. Res. Commun. 384 114-9 PubMed GONUTS page

[PMID:24598795-6] Loh, SL et al. (2014) Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep 4 4289 PubMed GONUTS page

[PMID:28350986-7] Nakajima, H et al. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev. Cell 40 523-536.e6 PubMed GONUTS page

[PMID:26209644-8] 8.0 ^8.1 Mateus, R et al. (2015) Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development 142 2752-63 PubMed GONUTS page

[PMID:25915126-9] Cebola, I et al. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat. Cell Biol. 17 615-626 PubMed GONUTS page

[PMID:25313964-10] Fukui, H et al. (2014) S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev. Cell 31 128-36 PubMed GONUTS page

[PMID:19439659-11] Skouloudaki, K et al. (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc. Natl. Acad. Sci. U.S.A. 106 8579-84 PubMed GONUTS page

[PMID:26209646-12] 12.0 ^12.1 ^12.2 Miesfeld, JB et al. (2015) Yap and Taz regulate retinal pigment epithelial cell fate. Development 142 3021-32 PubMed GONUTS page

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DANRE:YAP1

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