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PMID:19393221

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Citation

Jiang, Q, Liu, D, Gong, Y, Wang, Y, Sun, S, Gui, Y and Song, H (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem. Biophys. Res. Commun. 384:114-9

Abstract

The Yes-associated protein (YAP) is a small protein that binds to many transcription factors and modulates their activity. Bioinformatics analysis indicated that zebrafish Yap shares high identity with its orthologs in fruit fly, chicken, mouse, and human. Expression analysis revealed that maternal transcripts of yap are ubiquitous, and endogenous yap is chronologically expressed in the notochord, brain, eyes, branchial arches, and pectoral fins. Knockdown of yap causes distinct morphological defects in embryos, which display a small head with smaller eyes than normal and fewer cartilages in the branchial arches. Proneural and neuronal gene expression in yap morphant brain is significantly reduced. The expression of crestin is also markedly reduced in all recognizable arch-associated regions of yap morphants. Furthermore, TUNEL analysis revealed that there is a marked increase in cell death in yap morphant brain. In conclusion, zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis.

Links

PubMed Online version:10.1016/j.bbrc.2009.04.070

Keywords

Animals; Brain/embryology; Carrier Proteins/genetics; Carrier Proteins/physiology; Eye/embryology; Humans; Mice; Neural Crest/embryology; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:Q1L8J7

involved_in

GO:0007420: brain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090624-1

P

Seeded From UniProt

complete

DANRE:Q1L8J7

involved_in

GO:0051216: cartilage development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090624-1

P

Seeded From UniProt

complete

DANRE:YAP1

involved_in

GO:0007420: brain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090624-1

P

Seeded From UniProt

complete

DANRE:YAP1

involved_in

GO:0051216: cartilage development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-090624-1

P

Seeded From UniProt

complete


See also

References

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