DANRE:VGFR4

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	kdrl
Protein Name(s)	Vascular endothelial growth factor receptor kdr-like Fetal liver kinase 1 FLK-1 Kinase insert domain receptor-A Kinase insert domain receptor-like Protein-tyrosine kinase receptor flk-1 Vascular endothelial growth factor receptor 4 VEGFR-4
External Links
UniProt	Q8AXB3
EMBL	AY056466 AF487829 CU458916 AL935131 BC129158 AF180354 U89515 U82383 U75995
RefSeq	NP_571547.1
UniGene	Dr.75094
ProteinModelPortal	Q8AXB3
SMR	Q8AXB3
IntAct	Q8AXB3
PRIDE	Q8AXB3
GeneID	796537
KEGG	dre:796537
CTD	796537
ZFIN	ZDB-GENE-000705-1
eggNOG	COG0515
HOVERGEN	HBG053432
InParanoid	Q8AXB3
KO	K05096
PhylomeDB	Q8AXB3
NextBio	20932648
Proteomes	UP000000437
GO	GO:0016021 GO:0005886 GO:0005524 GO:0004713 GO:0004714 GO:0001525 GO:0048844 GO:0001568 GO:0030154 GO:0035050 GO:0018108 GO:0002040 GO:0030878 GO:0007169
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR001824
Pfam	PF07679 PF07714
SMART	SM00409 SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109 PS00240

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:16617120^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:16617120^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:0001525	angiogenesis	PMID:23393131^[2]	ECO:0000315			P	Figure 5. Knockdown of ECSCR reduces VEGF-stimulated KDR proteolysis, whereas overexpression of ECSCR results in increased total and surface KDR protein	complete CACAO 10774
involved_in	GO:0001525	angiogenesis	PMID:12194822^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	PMID:18656453^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090107-2	P	Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	PMID:16170785^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	PMID:16968815^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-040827-1	P	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:23462469^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-130719-5	P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:26483474^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050906-2 ZFIN:ZDB-MRPHLNO-080516-11	P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:23462469^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-130719-5	P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:16968815^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-040827-1	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:23086751^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080516-10 ZFIN:ZDB-MRPHLNO-080516-9	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16617120^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060515-1	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16617120^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-040827-1 ZFIN:ZDB-MRPHLNO-060515-1 ZFIN:ZDB-MRPHLNO-060515-2	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16617120^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-040827-1 ZFIN:ZDB-MRPHLNO-051212-2 ZFIN:ZDB-MRPHLNO-051212-3	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16617120^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-040827-1	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:25171174^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-141209-4	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:23086751^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080516-9	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:19269286^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090610-6	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:19269286^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090603-6	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:19269286^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090603-19	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:18656453^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090107-2	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16617120^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-040827-1	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:12194822^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-030804-1	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:97531 PANTHER:PTN001230896 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:96683 PANTHER:PTN002814439 RGD:2965 RGD:621737 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968 ZFIN:ZDB-GENE-980526-326	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 MGI:MGI:1339758 MGI:MGI:96677 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968	P	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C	Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001974926 UniProtKB:P35968	F	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814439 RGD:2965 UniProtKB:P17948 UniProtKB:P35968	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 RGD:2965 RGD:3284 RGD:3285 RGD:620568 UniProtKB:P07333 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C	Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96683 PANTHER:PTN001974926 RGD:2621 RGD:2965 RGD:621737 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968	F	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521319 ZFIN:ZDB-GENE-000705-1 ZFIN:ZDB-GENE-050407-1 ZFIN:ZDB-GENE-980526-326	P	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96683 PANTHER:PTN001562281 ZFIN:ZDB-GENE-000705-1 ZFIN:ZDB-GENE-050407-1 ZFIN:ZDB-GENE-980526-326	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521319 ZFIN:ZDB-GENE-050407-1	P	Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005021	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001824 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR001824 InterPro:IPR008266 InterPro:IPR020635	P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	P	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Covassin, LD et al. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 103 6554-9 PubMed GONUTS page
↑ Kilari, S et al. (2013) Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J. Biol. Chem. 288 10265-74 PubMed GONUTS page
↑ ^3.0 ^3.1 Habeck, H et al. (2002) Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr. Biol. 12 1405-12 PubMed GONUTS page
↑ ^4.0 ^4.1 Minehata, K et al. (2008) meis1 regulates the development of endothelial cells in zebrafish. Biochem. Biophys. Res. Commun. 374 647-52 PubMed GONUTS page
↑ Lee, YM et al. (2006) Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev. Dyn. 235 29-37 PubMed GONUTS page
↑ ^6.0 ^6.1 Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page
↑ ^7.0 ^7.1 Villefranc, JA et al. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development 140 1497-506 PubMed GONUTS page
↑ Jensen, LD et al. (2015) VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 112 E5944-53 PubMed GONUTS page
↑ ^9.0 ^9.1 Bridge, G et al. (2012) The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis. Blood 120 5063-72 PubMed GONUTS page
↑ Lai, JG et al. (2014) Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. PLoS ONE 9 e106129 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Covassin, LD et al. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev. Biol. 329 212-26 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16617120-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Covassin, LD et al. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 103 6554-9 PubMed GONUTS page

[PMID:23393131-2] Kilari, S et al. (2013) Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J. Biol. Chem. 288 10265-74 PubMed GONUTS page

[PMID:12194822-3] 3.0 ^3.1 Habeck, H et al. (2002) Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr. Biol. 12 1405-12 PubMed GONUTS page

[PMID:18656453-4] 4.0 ^4.1 Minehata, K et al. (2008) meis1 regulates the development of endothelial cells in zebrafish. Biochem. Biophys. Res. Commun. 374 647-52 PubMed GONUTS page

[PMID:16170785-5] Lee, YM et al. (2006) Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev. Dyn. 235 29-37 PubMed GONUTS page

[PMID:16968815-6] 6.0 ^6.1 Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page

[PMID:23462469-7] 7.0 ^7.1 Villefranc, JA et al. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development 140 1497-506 PubMed GONUTS page

[PMID:26483474-8] Jensen, LD et al. (2015) VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 112 E5944-53 PubMed GONUTS page

[PMID:23086751-9] 9.0 ^9.1 Bridge, G et al. (2012) The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis. Blood 120 5063-72 PubMed GONUTS page

[PMID:25171174-10] Lai, JG et al. (2014) Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. PLoS ONE 9 e106129 PubMed GONUTS page

[PMID:19269286-11] 11.0 ^11.1 ^11.2 Covassin, LD et al. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev. Biol. 329 212-26 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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[2]

[3]

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[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

DANRE:VGFR4

Contents

Annotations

Notes

References

a

b

c

d

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