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DANRE:VGFR4

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) kdrl
Protein Name(s) Vascular endothelial growth factor receptor kdr-like

Fetal liver kinase 1 FLK-1 Kinase insert domain receptor-A Kinase insert domain receptor-like Protein-tyrosine kinase receptor flk-1 Vascular endothelial growth factor receptor 4 VEGFR-4

External Links
UniProt Q8AXB3
EMBL AY056466
AF487829
CU458916
AL935131
BC129158
AF180354
U89515
U82383
U75995
RefSeq NP_571547.1
UniGene Dr.75094
ProteinModelPortal Q8AXB3
SMR Q8AXB3
IntAct Q8AXB3
PRIDE Q8AXB3
GeneID 796537
KEGG dre:796537
CTD 796537
ZFIN ZDB-GENE-000705-1
eggNOG COG0515
HOVERGEN HBG053432
InParanoid Q8AXB3
KO K05096
PhylomeDB Q8AXB3
NextBio 20932648
Proteomes UP000000437
GO GO:0016021
GO:0005886
GO:0005524
GO:0004713
GO:0004714
GO:0001525
GO:0048844
GO:0001568
GO:0030154
GO:0035050
GO:0018108
GO:0002040
GO:0030878
GO:0007169
Gene3D 2.60.40.10
InterPro IPR007110
IPR013783
IPR013098
IPR003599
IPR003598
IPR011009
IPR000719
IPR017441
IPR001245
IPR008266
IPR020635
IPR001824
Pfam PF07679
PF07714
SMART SM00409
SM00408
SM00219
SUPFAM SSF56112
PROSITE PS50835
PS00107
PS50011
PS00109
PS00240

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001525

angiogenesis

PMID:23393131[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5. Knockdown of ECSCR reduces VEGF-stimulated KDR proteolysis, whereas overexpression of ECSCR results in increased total and surface KDR protein

complete
CACAO 10774

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0001525

angiogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:12194822[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:12194822[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-030804-1

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:16617120[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-040827-1
ZFIN:ZDB-MRPHLNO-051212-2
ZFIN:ZDB-MRPHLNO-051212-3

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:16617120[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-040827-1
ZFIN:ZDB-MRPHLNO-060515-1

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:16617120[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-040827-1
ZFIN:ZDB-MRPHLNO-060515-1
ZFIN:ZDB-MRPHLNO-060515-2

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:16617120[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-040827-1

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:18656453[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090107-2

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:19269286[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-090603-19

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:19269286[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-090603-6

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:19269286[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-090610-6

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:25171174[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-141209-4

P

Seeded From UniProt

complete

GO:0001568

blood vessel development

PMID:16968815[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-040827-1

P

Seeded From UniProt

complete

GO:0001568

blood vessel development

PMID:23462469[8]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-130719-5

P

Seeded From UniProt

complete

GO:0002040

sprouting angiogenesis

PMID:23462469[8]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-130719-5

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

PMID:16617120[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001824

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17698971[9]

IPI: Inferred from Physical Interaction

UniProtKB:O73682-1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17698971[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q5RHW5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A4JYE7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A4JYI8

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A4JYN2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A4JYQ2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A8BB40

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A8BBB9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A8BBE6

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:A8BBG3

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q6NW92

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q6NZ26

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q6P5M1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q8UVD6

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20802085[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q90Z69

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001824
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR001824
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001824

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001824

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:16617120[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030878

thyroid gland development

PMID:16968815[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-040827-1

P

Seeded From UniProt

complete

GO:0035050

embryonic heart tube development

PMID:16170785[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048844

artery morphogenesis

PMID:18656453[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090107-2

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kilari, S et al. (2013) Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J. Biol. Chem. 288 10265-74 PubMed GONUTS page
  2. 2.0 2.1 Habeck, H et al. (2002) Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr. Biol. 12 1405-12 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Covassin, LD et al. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc. Natl. Acad. Sci. U.S.A. 103 6554-9 PubMed GONUTS page
  4. 4.0 4.1 Minehata, K et al. (2008) meis1 regulates the development of endothelial cells in zebrafish. Biochem. Biophys. Res. Commun. 374 647-52 PubMed GONUTS page
  5. 5.0 5.1 5.2 Covassin, LD et al. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev. Biol. 329 212-26 PubMed GONUTS page
  6. Lai, JG et al. (2014) Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling. PLoS ONE 9 e106129 PubMed GONUTS page
  7. 7.0 7.1 Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page
  8. 8.0 8.1 Villefranc, JA et al. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development 140 1497-506 PubMed GONUTS page
  9. 9.0 9.1 Bahary, N et al. (2007) Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood 110 3627-36 PubMed GONUTS page
  10. 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 Martin, S et al. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Mol. Cell Proteomics 9 2654-65 PubMed GONUTS page
  11. Lee, YM et al. (2006) Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev. Dyn. 235 29-37 PubMed GONUTS page