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DANRE:TAL1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) tal1 (ECO:0000312 with ZFIN:ZDB-GENE-980526-501)
Protein Name(s) T-cell acute lymphocytic leukemia protein 1 homolog

TAL-1 Stem cell protein zSCL

External Links
UniProt O93507
EMBL AF038873
AF045432
EF488003
EF488004
AL592495
BX664601
BX322568
BX322568
BX664601
BC068324
RefSeq NP_998402.1
UniGene Dr.75812
ProteinModelPortal O93507
STRING 7955.ENSDARP00000034906
DNASU 30766
Ensembl ENSDART00000083063
GeneID 30766
KEGG dre:30766
CTD 6886
ZFIN ZDB-GENE-980526-501
eggNOG NOG307510
GeneTree ENSGT00760000119097
HOGENOM HOG000113414
HOVERGEN HBG005018
InParanoid O93507
KO K09068
OMA GTQRAKT
OrthoDB EOG7SN8DF
PhylomeDB O93507
TreeFam TF315153
NextBio 20807108
PRO PR:O93507
Proteomes UP000000437
Bgee O93507
GO GO:0005634
GO:0003677
GO:0001525
GO:0048844
GO:0001568
GO:0060216
GO:0035050
GO:0035162
GO:0060214
GO:0030218
GO:0007507
GO:0003007
GO:0060217
GO:0060218
GO:0030097
GO:0048368
GO:0030099
GO:0048823
GO:0045603
GO:0060215
GO:0006355
GO:0030878
GO:0006351
GO:0001570
Gene3D 4.10.280.10
InterPro IPR011598
Pfam PF00010
SMART SM00353
SUPFAM SSF47459
PROSITE PS50888

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001015390

F

Seeded From UniProt

complete

GO:0000981

RNA polymerase II transcription factor activity, sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001015390

F

Seeded From UniProt

complete

GO:0001525

angiogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001525

angiogenesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-1
ZFIN:ZDB-MRPHLNO-050207-2

P

Seeded From UniProt

complete

GO:0001568

blood vessel development

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0001568

blood vessel development

PMID:16968815[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0001568

blood vessel development

PMID:20815916[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-501
ZFIN:ZDB-MRPHLNO-090506-1

P

Seeded From UniProt

complete

GO:0001570

vasculogenesis

PMID:9499398[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001570

vasculogenesis

PMID:9670018[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0003007

heart morphogenesis

PMID:17681136[7]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-050622-14

P

Seeded From UniProt

complete

GO:0003160

endocardium morphogenesis

PMID:24075907[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051221-7
ZFIN:ZDB-MRPHLNO-051221-9

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

PMID:16210319[9]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001015390

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16210319[9]

IC: Inferred by Curator

GO:0003677

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001015390

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007507

heart development

PMID:21750034[10]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050527-2
ZFIN:ZDB-MRPHLNO-060407-3

P

Seeded From UniProt

complete

GO:0019827

stem cell maintenance

PMID:24046317[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:14602685[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-1
ZFIN:ZDB-MRPHLNO-050207-2

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:16532340[13]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:9499398[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-118

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:9499398[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:9670018[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030097

hemopoiesis

PMID:9670018[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030099

myeloid cell differentiation

PMID:16210319[9]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030218

erythrocyte differentiation

PMID:14602685[12]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-419

P

Seeded From UniProt

complete

GO:0030218

erythrocyte differentiation

PMID:17472439[14]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0030878

thyroid gland development

PMID:16968815[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0035050

embryonic heart tube development

PMID:17722983[15]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070716-6

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:16753140[16]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-1
ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:18388326[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:18718762[18]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0035162

embryonic hemopoiesis

PMID:24046317[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070801-1

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:24984259[19]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045603

positive regulation of endothelial cell differentiation

PMID:9499398[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-118

P

Seeded From UniProt

complete

GO:0045603

positive regulation of endothelial cell differentiation

PMID:9670018[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046983

protein dimerization activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011598

F

Seeded From UniProt

complete

GO:0048368

lateral mesoderm development

PMID:20511544[20]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

complete

GO:0048823

nucleate erythrocyte development

PMID:17472439[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

complete

GO:0048823

nucleate erythrocyte development

PMID:17472439[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070801-1

P

Seeded From UniProt

complete

GO:0048844

artery morphogenesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048844

artery morphogenesis

PMID:17722983[15]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070716-6

P

Seeded From UniProt

complete

GO:0060214

endocardium formation

PMID:17722983[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060215

primitive hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060215

primitive hemopoiesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060215

primitive hemopoiesis

PMID:17472439[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060215

primitive hemopoiesis

PMID:19864643[21]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060215

primitive hemopoiesis

PMID:20410509[22]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060216

definitive hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060216

definitive hemopoiesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060216

definitive hemopoiesis

PMID:17472439[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060217

hemangioblast cell differentiation

PMID:14602685[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060217

hemangioblast cell differentiation

PMID:18388326[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

complete

GO:0060217

hemangioblast cell differentiation

PMID:9670018[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060217

hemangioblast cell differentiation

PMID:9670018[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060218

hematopoietic stem cell differentiation

PMID:17472439[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Dooley, KA et al. (2005) Zebrafish scl functions independently in hematopoietic and endothelial development. Dev. Biol. 277 522-36 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Patterson, LJ et al. (2005) Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood 105 3502-11 PubMed GONUTS page
  3. 3.0 3.1 Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page
  4. Mei, J et al. (2010) Mtmr8 is essential for vasculature development in zebrafish embryos. BMC Dev. Biol. 10 96 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Liao, EC et al. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 12 621-6 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Gering, M et al. (1998) The SCL gene specifies haemangioblast development from early mesoderm. EMBO J. 17 4029-45 PubMed GONUTS page
  7. Schoenebeck, JJ et al. (2007) Vessel and blood specification override cardiac potential in anterior mesoderm. Dev. Cell 13 254-67 PubMed GONUTS page
  8. Schumacher, JA et al. (2013) tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Dev. Biol. 383 214-26 PubMed GONUTS page
  9. 9.0 9.1 9.2 Juarez, MA et al. (2005) Distinct roles for SCL in erythroid specification and maturation in zebrafish. J. Biol. Chem. 280 41636-44 PubMed GONUTS page
  10. Simões, FC et al. (2011) Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development 138 3235-45 PubMed GONUTS page
  11. 11.0 11.1 Zhen, F et al. (2013) Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. Development 140 3977-85 PubMed GONUTS page
  12. 12.0 12.1 12.2 Gering, M et al. (2003) Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 130 6187-99 PubMed GONUTS page
  13. Hogan, BM et al. (2006) Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish. Dev. Genes Evol. 216 523-9 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 Qian, F et al. (2007) Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biol. 5 e132 PubMed GONUTS page
  15. 15.0 15.1 15.2 Bussmann, J et al. (2007) Early endocardial morphogenesis requires Scl/Tal1. PLoS Genet. 3 e140 PubMed GONUTS page
  16. Liu, YW & Guo, L (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev. Biol. 297 44-58 PubMed GONUTS page
  17. 17.0 17.1 Xiong, JW et al. (2008) An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish. Circ. Res. 102 1057-64 PubMed GONUTS page
  18. Liu, F et al. (2008) Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr. Biol. 18 1234-40 PubMed GONUTS page
  19. Schupp, MO et al. (2014) Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Dev. Biol. 393 71-83 PubMed GONUTS page
  20. Rowlinson, JM & Gering, M (2010) Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood 116 2046-56 PubMed GONUTS page
  21. Li, X et al. (2009) Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. Blood 114 5464-72 PubMed GONUTS page
  22. de Jong, JL et al. (2010) Interaction of retinoic acid and scl controls primitive blood development. Blood 116 201-9 PubMed GONUTS page