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DANRE:TAL1
Contents
Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
Gene Name(s) | tal1 (ECO:0000312 with ZFIN:ZDB-GENE-980526-501) | |
Protein Name(s) | T-cell acute lymphocytic leukemia protein 1 homolog
TAL-1 Stem cell protein zSCL | |
External Links | ||
UniProt | O93507 | |
EMBL | AF038873 AF045432 EF488003 EF488004 AL592495 BX664601 BX322568 BX322568 BX664601 BC068324 | |
RefSeq | NP_998402.1 | |
UniGene | Dr.75812 | |
ProteinModelPortal | O93507 | |
STRING | 7955.ENSDARP00000034906 | |
DNASU | 30766 | |
Ensembl | ENSDART00000083063 | |
GeneID | 30766 | |
KEGG | dre:30766 | |
CTD | 6886 | |
ZFIN | ZDB-GENE-980526-501 | |
eggNOG | NOG307510 | |
GeneTree | ENSGT00760000119097 | |
HOGENOM | HOG000113414 | |
HOVERGEN | HBG005018 | |
InParanoid | O93507 | |
KO | K09068 | |
OMA | GTQRAKT | |
OrthoDB | EOG7SN8DF | |
PhylomeDB | O93507 | |
TreeFam | TF315153 | |
NextBio | 20807108 | |
PRO | PR:O93507 | |
Proteomes | UP000000437 | |
Bgee | O93507 | |
GO | GO:0005634 GO:0003677 GO:0001525 GO:0048844 GO:0001568 GO:0060216 GO:0035050 GO:0035162 GO:0060214 GO:0030218 GO:0007507 GO:0003007 GO:0060217 GO:0060218 GO:0030097 GO:0048368 GO:0030099 GO:0048823 GO:0045603 GO:0060215 GO:0006355 GO:0030878 GO:0006351 GO:0001570 | |
Gene3D | 4.10.280.10 | |
InterPro | IPR011598 | |
Pfam | PF00010 | |
SMART | SM00353 | |
SUPFAM | SSF47459 | |
PROSITE | PS50888 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0060217 |
hemangioblast cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060217 |
hemangioblast cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060216 |
definitive hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060216 |
definitive hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060216 |
definitive hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060215 |
primitive hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060215 |
primitive hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060215 |
primitive hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060214 |
endocardium formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048844 |
artery morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030218 |
erythrocyte differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030099 |
myeloid cell differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000305 |
curator inference used in manual assertion |
GO:0003677 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001570 |
vasculogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060217 |
hemangioblast cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060405-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060217 |
hemangioblast cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060215 |
primitive hemopoiesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060215 |
primitive hemopoiesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048844 |
artery morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-070716-6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048823 |
nucleate erythrocyte development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-070801-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048823 |
nucleate erythrocyte development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060405-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048368 |
lateral mesoderm development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045603 |
positive regulation of endothelial cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-118 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045603 |
positive regulation of endothelial cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035162 |
embryonic hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-070801-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035162 |
embryonic hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035162 |
embryonic hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060405-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035162 |
embryonic hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050207-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035162 |
embryonic hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035050 |
embryonic heart tube development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-070716-6 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030878 |
thyroid gland development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030218 |
erythrocyte differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-980526-419 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENO-980202-118 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050207-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030097 |
hemopoiesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019827 |
stem cell population maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-060405-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007507 |
heart development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003160 |
endocardium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-051221-7 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003007 |
heart morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-050622-14 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001570 |
vasculogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001568 |
blood vessel development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-980526-501 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001568 |
blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001568 |
blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050527-2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-050207-1 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98480 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98480 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98480 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001015390 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060218 |
hematopoietic stem cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Gering, M et al. (2003) Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 130 6187-99 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gering, M et al. (1998) The SCL gene specifies haemangioblast development from early mesoderm. EMBO J. 17 4029-45 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Dooley, KA et al. (2005) Zebrafish scl functions independently in hematopoietic and endothelial development. Dev. Biol. 277 522-36 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Qian, F et al. (2007) Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biol. 5 e132 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Patterson, LJ et al. (2005) Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood 105 3502-11 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Bussmann, J et al. (2007) Early endocardial morphogenesis requires Scl/Tal1. PLoS Genet. 3 e140 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Juarez, MA et al. (2005) Distinct roles for SCL in erythroid specification and maturation in zebrafish. J. Biol. Chem. 280 41636-44 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Liao, EC et al. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 12 621-6 PubMed GONUTS page
- ↑ 9.0 9.1 Xiong, JW et al. (2008) An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish. Circ. Res. 102 1057-64 PubMed GONUTS page
- ↑ de Jong, JL et al. (2010) Interaction of retinoic acid and scl controls primitive blood development. Blood 116 201-9 PubMed GONUTS page
- ↑ Li, X et al. (2009) Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. Blood 114 5464-72 PubMed GONUTS page
- ↑ Rowlinson, JM & Gering, M (2010) Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood 116 2046-56 PubMed GONUTS page
- ↑ Schupp, MO et al. (2014) Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Dev. Biol. 393 71-83 PubMed GONUTS page
- ↑ 14.0 14.1 Zhen, F et al. (2013) Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. Development 140 3977-85 PubMed GONUTS page
- ↑ Liu, F et al. (2008) Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr. Biol. 18 1234-40 PubMed GONUTS page
- ↑ Liu, YW & Guo, L (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev. Biol. 297 44-58 PubMed GONUTS page
- ↑ 17.0 17.1 Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page
- ↑ Hogan, BM et al. (2006) Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish. Dev. Genes Evol. 216 523-9 PubMed GONUTS page
- ↑ Simões, FC et al. (2011) Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development 138 3235-45 PubMed GONUTS page
- ↑ Schumacher, JA et al. (2013) tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Dev. Biol. 383 214-26 PubMed GONUTS page
- ↑ Schoenebeck, JJ et al. (2007) Vessel and blood specification override cardiac potential in anterior mesoderm. Dev. Cell 13 254-67 PubMed GONUTS page
- ↑ Mei, J et al. (2010) Mtmr8 is essential for vasculature development in zebrafish embryos. BMC Dev. Biol. 10 96 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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