DANRE:Q1L8J7

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	CH211-181P1.5 (ECO:0000313 with EMBL:CAK04259.2) (synonyms: yap1 (ECO:0000313 with Ensembl:ENSDARP00000089684))
Protein Name(s)	Novel protein similar to vertebrate Yes-associated protein 1, 65kDa (YAP1)(Si:ch211-181p1.5) (ECO:0000313 with EMBL:CAK04259.2) Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000089684)
External Links
UniProt	Q1L8J7
EMBL	AL954841 CR762425 CT573116
RefSeq	NP_001132952.1
UniGene	Dr.119226 Dr.75317
SMR	Q1L8J7
Ensembl	ENSDART00000098914
GeneID	561411
KEGG	dre:561411
CTD	10413
ZFIN	ZDB-GENE-030131-9710
GeneTree	ENSGT00510000046760
HOVERGEN	HBG002748
KO	K16687
OMA	LRQSSYE
OrthoDB	EOG75MVW6
PhylomeDB	Q1L8J7
TreeFam	TF326941
Reactome	REACT_207589 REACT_218772 REACT_221166 REACT_225633
NextBio	20883913
PRO	PR:Q1L8J7
Proteomes	UP000000437
InterPro	IPR001202
Pfam	PF00397
SMART	SM00456
SUPFAM	SSF51045
PROSITE	PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:23494967^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23494967^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009950	dorsal/ventral axis specification	PMID:23494967^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060914	heart formation	PMID:23494967^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	PMID:23494967^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1905480	positive regulation of glutamate-ammonia ligase activity	PMID:27428308^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-161027-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:26157348^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:19393221^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
involved_in	GO:0048916	posterior lateral line development	PMID:24598795^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-140915-6	P	Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	PMID:28350986^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-170615-6	P	Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	PMID:27428308^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-161027-2	P	Seeded From UniProt	complete
involved_in	GO:0039022	pronephric duct development	PMID:26157348^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:26209644^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160901-9	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:26209644^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160901-10	P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:25915126^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090609-10	P	Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	PMID:25313964^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090609-10	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:19393221^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090624-1	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19439659^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:26209646^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-160122-4	P	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:26209646^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160122-9	P	Seeded From UniProt	complete
involved_in	GO:0003406	retinal pigment epithelium development	PMID:26209646^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-160122-3	P	Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:27428308^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Hu, J et al. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int. J. Biol. Sci. 9 267-78 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Cox, AG et al. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat. Cell Biol. 18 886-896 PubMed GONUTS page
↑ ^3.0 ^3.1 He, L et al. (2015) Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int. J. Biol. Sci. 11 935-47 PubMed GONUTS page
↑ ^4.0 ^4.1 Jiang, Q et al. (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem. Biophys. Res. Commun. 384 114-9 PubMed GONUTS page
↑ Loh, SL et al. (2014) Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep 4 4289 PubMed GONUTS page
↑ Nakajima, H et al. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev. Cell 40 523-536.e6 PubMed GONUTS page
↑ ^7.0 ^7.1 Mateus, R et al. (2015) Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development 142 2752-63 PubMed GONUTS page
↑ Cebola, I et al. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat. Cell Biol. 17 615-626 PubMed GONUTS page
↑ Fukui, H et al. (2014) S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev. Cell 31 128-36 PubMed GONUTS page
↑ Skouloudaki, K et al. (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc. Natl. Acad. Sci. U.S.A. 106 8579-84 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Miesfeld, JB et al. (2015) Yap and Taz regulate retinal pigment epithelial cell fate. Development 142 3021-32 PubMed GONUTS page

[PMID:23494967-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Hu, J et al. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int. J. Biol. Sci. 9 267-78 PubMed GONUTS page

[PMID:27428308-2] 2.0 ^2.1 ^2.2 Cox, AG et al. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat. Cell Biol. 18 886-896 PubMed GONUTS page

[PMID:26157348-3] 3.0 ^3.1 He, L et al. (2015) Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int. J. Biol. Sci. 11 935-47 PubMed GONUTS page

[PMID:19393221-4] 4.0 ^4.1 Jiang, Q et al. (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem. Biophys. Res. Commun. 384 114-9 PubMed GONUTS page

[PMID:24598795-5] Loh, SL et al. (2014) Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep 4 4289 PubMed GONUTS page

[PMID:28350986-6] Nakajima, H et al. (2017) Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev. Cell 40 523-536.e6 PubMed GONUTS page

[PMID:26209644-7] 7.0 ^7.1 Mateus, R et al. (2015) Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development 142 2752-63 PubMed GONUTS page

[PMID:25915126-8] Cebola, I et al. (2015) TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat. Cell Biol. 17 615-626 PubMed GONUTS page

[PMID:25313964-9] Fukui, H et al. (2014) S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev. Cell 31 128-36 PubMed GONUTS page

[PMID:19439659-10] Skouloudaki, K et al. (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc. Natl. Acad. Sci. U.S.A. 106 8579-84 PubMed GONUTS page

[PMID:26209646-11] 11.0 ^11.1 ^11.2 Miesfeld, JB et al. (2015) Yap and Taz regulate retinal pigment epithelial cell fate. Development 142 3021-32 PubMed GONUTS page

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DANRE:Q1L8J7

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