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DANRE:H90A1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) hsp90a.1 (synonyms: hsp90, hsp90a, hsp90aa1)
Protein Name(s) Heat shock protein HSP 90-alpha 1
External Links
UniProt Q90474
EMBL AF068773
CR381646
BC075757
L35586
PIR JC2343
RefSeq NP_571403.1
UniGene Dr.75834
ProteinModelPortal Q90474
SMR Q90474
PRIDE Q90474
Ensembl ENSDART00000004756
GeneID 30591
KEGG dre:30591
CTD 30591
ZFIN ZDB-GENE-990415-94
eggNOG COG0326
GeneTree ENSGT00760000119253
HOGENOM HOG000031988
HOVERGEN HBG007374
InParanoid Q90474
KO K04079
OMA EDISRME
OrthoDB EOG780RM0
PhylomeDB Q90474
TreeFam TF300686
NextBio 20806959
Proteomes UP000000437
Bgee Q90474
GO GO:0031672
GO:0042470
GO:0048471
GO:0030018
GO:0005524
GO:0030235
GO:0007517
GO:0030239
GO:0045429
GO:0006457
GO:0050790
GO:0006950
GO:0048769
GO:0030241
GO:0030240
GO:0014866
GO:0071688
Gene3D 3.30.565.10
HAMAP MF_00505
InterPro IPR003594
IPR019805
IPR001404
IPR020575
IPR020568
PANTHER PTHR11528
Pfam PF02518
PF00183
PIRSF PIRSF002583
PRINTS PR00775
SMART SM00387
SUPFAM SSF54211
SSF55874
PROSITE PS00298

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006950

response to stress

PMID:25366476[1]

IDA: Inferred from Direct Assay

P

Figure 1 HSP90 reduced infarct size shows inflammatory response signalling pathway inhibited by 17-DMAG in TCC-stained mouse brain section

complete
CACAO 10293

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0006457

protein folding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

P

Seeded From UniProt

complete

GO:0006950

response to stress

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0517

P

Seeded From UniProt

complete

GO:0014866

skeletal myofibril assembly

PMID:18182494[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080405-1

P

Seeded From UniProt

complete

GO:0030018

Z disc

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0314

C

Seeded From UniProt

complete

GO:0030018

Z disc

PMID:18347070[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030235

nitric-oxide synthase regulator activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P07901

F

Seeded From UniProt

complete

GO:0030239

myofibril assembly

PMID:17586488[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-071128-2

P

Seeded From UniProt

complete

GO:0030240

skeletal muscle thin filament assembly

PMID:20049323[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1042

P

Seeded From UniProt

complete

GO:0030241

skeletal muscle myosin thick filament assembly

PMID:18256191[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080401-1

P

Seeded From UniProt

complete

GO:0031672

A band

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0476

C

Seeded From UniProt

complete

GO:0042470

melanosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0161

C

Seeded From UniProt

complete

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P07901

P

Seeded From UniProt

complete

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

GO:0048769

sarcomerogenesis

PMID:18256191[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080401-1

P

Seeded From UniProt

complete

GO:0050790

regulation of catalytic activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P07901

P

Seeded From UniProt

complete

GO:0051082

unfolded protein binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001404
InterPro:IPR019805

F

Seeded From UniProt

complete

GO:0071688

striated muscle myosin thick filament assembly

PMID:20049323[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1042

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Qi, J et al. (2014) 17-Dimethylaminoethylamino-17-demethoxygeldanamycin attenuates inflammatory responses in experimental stroke. Biol. Pharm. Bull. 37 1713-8 PubMed GONUTS page
  2. Du, SJ et al. (2008) Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos. Proc. Natl. Acad. Sci. U.S.A. 105 554-9 PubMed GONUTS page
  3. Etard, C et al. (2008) Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril. J. Cell Biol. 180 1163-75 PubMed GONUTS page
  4. Etard, C et al. (2007) The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Dev. Biol. 308 133-43 PubMed GONUTS page
  5. 5.0 5.1 Codina, M et al. (2010) Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos. PLoS ONE 5 e8416 PubMed GONUTS page
  6. 6.0 6.1 Hawkins, TA et al. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development 135 1147-56 PubMed GONUTS page