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DANRE:FEZF2

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) fezf2 (synonyms: fezl)
Protein Name(s) Fez family zinc finger protein 2

Forebrain embryonic zinc finger-like protein 2 Foreheadin protein Zinc finger protein Fez-like

External Links
UniProt Q804Q5
EMBL AB041824
AF281076
AY078361
AL672211
BC085677
RefSeq NP_571711.1
UniGene Dr.82591
ProteinModelPortal Q804Q5
STRING 7955.ENSDARP00000094772
GeneID 60634
KEGG dre:60634
CTD 55079
ZFIN ZDB-GENE-001103-3
eggNOG COG5048
HOGENOM HOG000013052
HOVERGEN HBG098441
InParanoid Q804Q5
PhylomeDB Q804Q5
NextBio 20892420
PRO PR:Q804Q5
Proteomes UP000000437
Bgee Q804Q5
GO GO:0005634
GO:0003677
GO:0046872
GO:0030154
GO:0007399
GO:0006355
GO:0006351
Gene3D 3.30.160.60
InterPro IPR007087
IPR015880
IPR013087
Pfam PF00096
SMART SM00355
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0097150

neuronal stem cell population maintenance

PMID:25319688[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-150707-6

P

Seeded From UniProt

complete

involved_in

GO:0071679

commissural neuron axon guidance

PMID:21471212[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070129-7

P

Seeded From UniProt

complete

involved_in

GO:0071679

commissural neuron axon guidance

PMID:21471212[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-110701-16

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:12469125[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030900

forebrain development

PMID:12469125[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030900

forebrain development

PMID:12469125[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070129-9

P

Seeded From UniProt

complete

involved_in

GO:0021954

central nervous system neuron development

PMID:10191060[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070129-9

P

Seeded From UniProt

complete

involved_in

GO:0021879

forebrain neuron differentiation

PMID:18799544[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070129-9

P

Seeded From UniProt

complete

involved_in

GO:0021854

hypothalamus development

PMID:18003738[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070129-9
ZFIN:ZDB-MRPHLNO-070129-7
ZFIN:ZDB-MRPHLNO-080414-2

P

Seeded From UniProt

complete

involved_in

GO:0021854

hypothalamus development

PMID:18003738[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070129-9

P

Seeded From UniProt

complete

involved_in

GO:0021767

mammillary body development

PMID:23533176[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070129-7

P

Seeded From UniProt

complete

involved_in

GO:0021536

diencephalon development

PMID:17164418[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070129-7

P

Seeded From UniProt

complete

involved_in

GO:0021536

diencephalon development

PMID:17164418[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-070129-6

P

Seeded From UniProt

complete

involved_in

GO:0021536

diencephalon development

PMID:17164418[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070706-5

P

Seeded From UniProt

complete

involved_in

GO:0008593

regulation of Notch signaling pathway

PMID:25319688[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-150707-6

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:15219677[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-070129-9

P

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106679
MGI:MGI:106683
MGI:MGI:1929518
PANTHER:PTN002323202
UniProtKB:Q15915
UniProtKB:Q8JJC0
ZFIN:ZDB-GENE-000208-4
ZFIN:ZDB-GENE-000710-4
ZFIN:ZDB-GENE-001103-3
ZFIN:ZDB-GENE-030219-92
ZFIN:ZDB-GENE-040622-1
ZFIN:ZDB-GENE-040622-4
ZFIN:ZDB-GENE-061207-1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003002
FB:FBgn0039039
MGI:MGI:106676
MGI:MGI:106679
MGI:MGI:106683
MGI:MGI:107201
MGI:MGI:1929518
MGI:MGI:1932535
PANTHER:PTN001803442
SGD:S000002553
SGD:S000003592
SGD:S000004121
UniProtKB:O95409
UniProtKB:Q15915
WB:WBGene00004335
WB:WBGene00006604
dictyBase:DDB_G0291342

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003002
PANTHER:PTN001803442
SGD:S000002553
SGD:S000003592

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003002
MGI:MGI:106676
MGI:MGI:106679
MGI:MGI:106683
MGI:MGI:107201
MGI:MGI:1929518
MGI:MGI:1932535
PANTHER:PTN001803442
SGD:S000003592
WB:WBGene00004335
WB:WBGene00006604

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Berberoglu, MA et al. (2014) Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J. Neurosci. 34 13911-23 PubMed GONUTS page
  2. ↑ 2.0 2.1 Chen, L et al. (2011) Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J. Biol. Chem. 286 18641-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Levkowitz, G et al. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nat. Neurosci. 6 28-33 PubMed GONUTS page
  4. ↑ Guo, S et al. (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev. Biol. 208 473-87 PubMed GONUTS page
  5. ↑ Russek-Blum, N et al. (2008) Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development 135 3401-13 PubMed GONUTS page
  6. ↑ 6.0 6.1 Blechman, J et al. (2007) Specification of hypothalamic neurons by dual regulation of the homeodomain protein Orthopedia. Development 134 4417-26 PubMed GONUTS page
  7. ↑ Wolf, A & Ryu, S (2013) Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development 140 1762-73 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Jeong, JY et al. (2007) Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development 134 127-36 PubMed GONUTS page
  9. ↑ Rink, E & Guo, S (2004) The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience 127 147-54 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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