PMID:12469125

Citation	Levkowitz, G, Zeller, J, Sirotkin, HI, French, D, Schilbach, S, Hashimoto, H, Hibi, M, Talbot, WS and Rosenthal, A (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nat. Neurosci. 6:28-33
Abstract	The mechanism controlling the development of dopaminergic (DA) and serotonergic (5HT) neurons in vertebrates is not well understood. Here we characterized a zebrafish mutant--too few (tof)--that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons non-cell-autonomously. Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function. Our results indicate that tof/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain.
Links	PubMed Online version:10.1038/nn979
Keywords	Animals; Anti-Bacterial Agents/chemical synthesis; Apoptosis/genetics; Biogenic Monoamines/metabolism; Brain/cytology; Brain/embryology; Brain/metabolism; Brain Tissue Transplantation; Carrier Proteins/genetics; Carrier Proteins/isolation & purification; Cell Differentiation/genetics; Chromosome Mapping; Dopamine/metabolism; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental/genetics; Male; Neurons/cytology; Neurons/metabolism; Peptides; Repressor Proteins/genetics; Repressor Proteins/isolation & purification; Serotonin/metabolism; Signal Transduction/genetics; Stem Cells/cytology; Stem Cells/metabolism; Zebrafish; Zebrafish Proteins; Zinc Fingers/genetics
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