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Category:Team Free Radicals

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorHUMAN:POTE1Lriffert, Team Free Radicals2018-04-22 13:30:22 CDTGO:2001032 regulation of double-strand break repair via nonhomologous end joining (P)PMID:29227966ECO:0000314 direct assay evidence used in manual assertion

Figure 2

POT1 promotes NHEJ fidelity but inhibits NHEJ efficiency

challenge
unacceptableHUMAN:NOTC1Lriffert, Team Free Radicals2018-04-17 13:13:28 CDTGO:0031953 negative regulation of protein autophosphorylation (P)PMID:29482073ECO:0000314 direct assay evidence used in manual assertion

Figure 1C and S1C, NOTCH1 impairs DNA-PKcs autophosphorylation (Ser2065) to a similar, although 

slightly lower, extent as the small molecule DNA-PKcsi.
challenge
updatedbyinstructorHUMAN:PNKPDbryant, Team Free Radicals2018-04-13 20:58:47 CDTGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining (P)PMID:12032095ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6A&B, PNK depleted GM00558 extracts showed similar deficiency as RAD51-depleted extracts in promoting end joining of linear DNA molecules with 5’-OH termini.

challenge
acceptableDICDI:Q54XI2Dbryant, Team Free Radicals2018-04-12 09:36:34 CDTGO:0006303 double-strand break repair via nonhomologous end joining (P)PMID:21807880ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4, disruption of adprt1a cells had the lowest REMI index compared to disrupted Ku80 cells. Collective data show DSB-induced PARylation by Adprt1a promotes NHEJ over HR, indicating adprt1a has a role in promoting NHEJ repair pathway.

challenge
acceptableYEAST:HMO1Lriffert, Team Free Radicals2018-04-11 10:55:13 CDTGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining (P)PMID:28336179ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1B-I, absolute repair efficiency in wild-type DDY3.

challenge

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Pages in category "Team Free Radicals"

The following 3 pages are in this category, out of 3 total.


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