DICDI:Q54XI2

Species (Taxon ID)	Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s)	adprt1A (ECO:0000313 with EMBL:EAL67972.1)
Protein Name(s)	Poly [ADP-ribose] polymerase (ECO:0000256 with RuleBase:RU362114) PARP (ECO:0000256 with RuleBase:RU362114)
External Links
UniProt	Q54XI2
EMBL	AAFI02000024
RefSeq	XP_647821.1
ProteinModelPortal	Q54XI2
SMR	Q54XI2
STRING	44689.DDB0214818
PaxDb	Q54XI2
EnsemblProtists	EAL67972
GeneID	8621781
KEGG	ddi:DDB_G0278741
dictyBase	DDB_G0278741
eggNOG	KOG1037 ENOG410XP18
InParanoid	Q54XI2
KO	K10798
OMA	WNHASCI
PhylomeDB	Q54XI2
Reactome	R-DDI-110362 R-DDI-5696394 R-DDI-5696395
Proteomes	UP000002195
GO	GO:0005737 GO:0005634 GO:0003677 GO:0003910 GO:0003950 GO:0008270 GO:0031152 GO:0051103 GO:0006302 GO:0006303 GO:0010421 GO:0006273 GO:0010918 GO:1903518 GO:0006471 GO:0070213 GO:0071168 GO:0070212 GO:0051726 GO:0072718 GO:0006979
Gene3D	1.20.142.10 2.20.140.10 3.30.1740.10 3.40.50.10190
InterPro	IPR001357 IPR036420 IPR012982 IPR012317 IPR004102 IPR036616 IPR036930 IPR008893 IPR001510 IPR036957
Pfam	PF08063 PF00644 PF02877 PF05406 PF00645
SMART	SM01335 SM00773 SM01336
SUPFAM	SSF142921 SSF47587
PROSITE	PS50172 PS51060 PS51059 PS50064

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21807880^[1]	ECO:0000315			P		Figure 4, disruption of adprt1a cells had the lowest REMI index compared to disrupted Ku80 cells. Collective data show DSB-induced PARylation by Adprt1a promotes NHEJ over HR, indicating adprt1a has a role in promoting NHEJ repair pathway.	complete CACAO 13232
involved_in	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	PMID:28973445^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28252050^[3]	ECO:0000305	curator inference used in manual assertion	GO:1990404	C		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	PMID:21807880^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(GO:0043564) happens_during:(GO:0006303)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q55AK6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q86KC8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54HY5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006302	double-strand break repair	PMID:21807880^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8I7C6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006302	double-strand break repair	PMID:21807880^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010225	response to UV-C	PMID:25858552^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54LJ4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8I7C6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q55GU8	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54X55	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54E42	P		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	PMID:21807880^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q54LY5) happens_during:(GO:0006303)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09874	F		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:8328967^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990404	protein ADP-ribosylase activity	PMID:21807880^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
is_active_in	GO:0005634	nucleus	PMID:21807880^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990404	protein ADP-ribosylase activity	PMID:28252050^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0100014) occurs_at:(SO:0001454)	Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	PMID:28252050^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0000729) has_input:(UniProtKB:Q54LP8)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	PMID:27021638^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:27021638^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072718	response to cisplatin	PMID:27587838^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8I7C6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010918	positive regulation of mitochondrial membrane potential	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54E42 UniProtKB:Q54HY5 UniProtKB:Q54LJ4 UniProtKB:Q54X55 UniProtKB:Q55AK6 UniProtKB:Q55GU8 UniProtKB:Q86KC8 UniProtKB:Q8I7C6	P	happens_during:(GO:0034599)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010421	hydrogen peroxide-mediated programmed cell death	PMID:24129923^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54E42 UniProtKB:Q54HY5 UniProtKB:Q54LJ4 UniProtKB:Q54X55 UniProtKB:Q55AK6 UniProtKB:Q55GU8 UniProtKB:Q86KC8 UniProtKB:Q8I7C6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903518	positive regulation of single strand break repair	PMID:23750002^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8I7C6	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21807880^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:21385463^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990404	protein ADP-ribosylase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 PANTHER:PTN000396992 UniProtKB:P09874 UniProtKB:Q9UGN5	F		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 MGI:MGI:1891258 PANTHER:PTN000396992 UniProtKB:P09874 UniProtKB:Q9Y6F1 dictyBase:DDB_G0278741 dictyBase:DDB_G0292820	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010247 MGI:MGI:1340806 MGI:MGI:1341112 PANTHER:PTN000396992 UniProtKB:P09874 UniProtKB:Q9UGN5	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1340806 MGI:MGI:1341112 PANTHER:PTN000396992 RGD:2053 TAIR:locus:2005523 UniProtKB:P09874 UniProtKB:Q9UGN5 dictyBase:DDB_G0278741 dictyBase:DDB_G0279195 dictyBase:DDB_G0292820	C		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010247 MGI:MGI:1340806 MGI:MGI:1341112 PANTHER:PTN000396992 RGD:2053 TAIR:locus:2042511 UniProtKB:P09874 UniProtKB:Q9Y6F1 WB:WBGene00004049 WB:WBGene00004050	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001510 InterPro:IPR036957	F		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004102 InterPro:IPR012317 InterPro:IPR036616	F		Seeded From UniProt	complete
involved_in	GO:0006471	protein ADP-ribosylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004102 InterPro:IPR036616	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001510 InterPro:IPR036957	F		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.2.30	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
enables	GO:0003950	NAD+ ADP-ribosyltransferase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000078407	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Couto, CA et al. (2011) PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks. J. Cell Biol. 194 367-75 PubMed GONUTS page
↑ Kolb, AL et al. (2017) Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium. Nucleic Acids Res. 45 10056-10067 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Rakhimova, A et al. (2017) Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep 7 43750 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Rajawat, J et al. (2014) Involvement of poly(ADP-ribose) polymerase in paraptotic cell death of D. discoideum. Apoptosis 19 90-101 PubMed GONUTS page
↑ Mir, H et al. (2015) Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase. Cell Prolif. 48 363-74 PubMed GONUTS page
↑ Kofler, B et al. (1993) Purification and characterization of NAD+:ADP-ribosyltransferase (polymerizing) from Dictyostelium discoideum. Biochem. J. 293 ( Pt 1) 275-81 PubMed GONUTS page
↑ ^7.0 ^7.1 Jubin, T et al. () Poly (ADP-ribose) polymerase1 regulates growth and multicellularity in D. discoideum. Differentiation 92 10-23 PubMed GONUTS page
↑ Gunn, AR et al. (2016) The role of ADP-ribosylation in regulating DNA interstrand crosslink repair. J. Cell. Sci. 129 3845-3858 PubMed GONUTS page
↑ Couto, CA et al. (2013) Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks. J. Cell. Sci. 126 3452-61 PubMed GONUTS page
↑ Rajawat, J et al. (2011) Differential role of poly(ADP-ribose) polymerase in D. discoideum growth and development. BMC Dev. Biol. 11 14 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21807880-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Couto, CA et al. (2011) PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks. J. Cell Biol. 194 367-75 PubMed GONUTS page

[PMID:28973445-2] Kolb, AL et al. (2017) Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium. Nucleic Acids Res. 45 10056-10067 PubMed GONUTS page

[PMID:28252050-3] 3.0 ^3.1 ^3.2 Rakhimova, A et al. (2017) Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep 7 43750 PubMed GONUTS page

[PMID:24129923-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Rajawat, J et al. (2014) Involvement of poly(ADP-ribose) polymerase in paraptotic cell death of D. discoideum. Apoptosis 19 90-101 PubMed GONUTS page

[PMID:25858552-5] Mir, H et al. (2015) Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase. Cell Prolif. 48 363-74 PubMed GONUTS page

[PMID:8328967-6] Kofler, B et al. (1993) Purification and characterization of NAD+:ADP-ribosyltransferase (polymerizing) from Dictyostelium discoideum. Biochem. J. 293 ( Pt 1) 275-81 PubMed GONUTS page

[PMID:27021638-7] 7.0 ^7.1 Jubin, T et al. () Poly (ADP-ribose) polymerase1 regulates growth and multicellularity in D. discoideum. Differentiation 92 10-23 PubMed GONUTS page

[PMID:27587838-8] Gunn, AR et al. (2016) The role of ADP-ribosylation in regulating DNA interstrand crosslink repair. J. Cell. Sci. 129 3845-3858 PubMed GONUTS page

[PMID:23750002-9] Couto, CA et al. (2013) Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks. J. Cell. Sci. 126 3452-61 PubMed GONUTS page

[PMID:21385463-10] Rajawat, J et al. (2011) Differential role of poly(ADP-ribose) polymerase in D. discoideum growth and development. BMC Dev. Biol. 11 14 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DICDI:Q54XI2

Contents

Annotations

Notes

References

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