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DICDI:Q54XI2

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) adprt1A (ECO:0000313 with EMBL:EAL67972.1)
Protein Name(s) Poly [ADP-ribose] polymerase (ECO:0000256 with RuleBase:RU362114)

PARP (ECO:0000256 with RuleBase:RU362114)

External Links
UniProt Q54XI2
EMBL AAFI02000024
RefSeq XP_647821.1
ProteinModelPortal Q54XI2
SMR Q54XI2
STRING 44689.DDB0214818
PaxDb Q54XI2
EnsemblProtists EAL67972
GeneID 8621781
KEGG ddi:DDB_G0278741
dictyBase DDB_G0278741
eggNOG KOG1037
ENOG410XP18
InParanoid Q54XI2
KO K10798
OMA WNHASCI
PhylomeDB Q54XI2
Reactome R-DDI-110362
R-DDI-5696394
R-DDI-5696395
Proteomes UP000002195
GO GO:0005737
GO:0005634
GO:0003677
GO:0003910
GO:0003950
GO:0008270
GO:0031152
GO:0051103
GO:0006302
GO:0006303
GO:0010421
GO:0006273
GO:0010918
GO:1903518
GO:0006471
GO:0070213
GO:0071168
GO:0070212
GO:0051726
GO:0072718
GO:0006979
Gene3D 1.20.142.10
2.20.140.10
3.30.1740.10
3.40.50.10190
InterPro IPR001357
IPR036420
IPR012982
IPR012317
IPR004102
IPR036616
IPR036930
IPR008893
IPR001510
IPR036957
Pfam PF08063
PF00644
PF02877
PF05406
PF00645
SMART SM01335
SM00773
SM01336
SUPFAM SSF142921
SSF47587
PROSITE PS50172
PS51060
PS51059
PS50064

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006303

double-strand break repair via nonhomologous end joining

PMID:21807880[1]

ECO:0000315

P

Figure 4, disruption of adprt1a cells had the lowest REMI index compared to disrupted Ku80 cells. Collective data show DSB-induced PARylation by Adprt1a promotes NHEJ over HR, indicating adprt1a has a role in promoting NHEJ repair pathway.

complete
CACAO 13232

GO:0070212

protein poly-ADP-ribosylation

PMID:21807880[1]

ECO:0000315

P

Figure 3, significant reduction of DSB-induced PARylation is observed in the adprt1a strain, indicating adprt1a is required for nuclear PARylation after DSBs.

complete
CACAO 13290

involved_in

GO:0070213

protein auto-ADP-ribosylation

PMID:28973445[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28252050[3]

ECO:0000305

curator inference used in manual assertion

GO:1990404

C

Seeded From UniProt

complete

involved_in

GO:0071168

protein localization to chromatin

PMID:21807880[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q55AK6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q86KC8

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54HY5

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006302

double-strand break repair

PMID:21807880[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8I7C6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006302

double-strand break repair

PMID:21807880[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010225

response to UV-C

PMID:25858552[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54LJ4

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8I7C6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q55GU8

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54X55

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54E42

P

Seeded From UniProt

complete

involved_in

GO:0070212

protein poly-ADP-ribosylation

PMID:21807880[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8I7C6

P

happens_during:(GO:0000729)

Seeded From UniProt

complete

involved_in

GO:0070212

protein poly-ADP-ribosylation

PMID:21807880[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

happens_during:(GO:0000729)

Seeded From UniProt

complete

involved_in

GO:0071168

protein localization to chromatin

PMID:21807880[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09874

F

Seeded From UniProt

complete

enables

GO:0003950

NAD+ ADP-ribosyltransferase activity

PMID:8328967[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:1990404

protein ADP-ribosylase activity

PMID:21807880[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

is_active_in

GO:0005634

nucleus

PMID:21807880[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:1990404

protein ADP-ribosylase activity

PMID:28252050[3]

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_at:(SO:0100014)
  • occurs_at:(SO:0001454)

Seeded From UniProt

complete

involved_in

GO:0006471

protein ADP-ribosylation

PMID:28252050[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051726

regulation of cell cycle

PMID:27021638[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:27021638[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072718

response to cisplatin

PMID:27587838[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8I7C6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010918

positive regulation of mitochondrial membrane potential

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54E42
UniProtKB:Q54HY5
UniProtKB:Q54LJ4
UniProtKB:Q54X55
UniProtKB:Q55AK6
UniProtKB:Q55GU8
UniProtKB:Q86KC8
UniProtKB:Q8I7C6

P

happens_during:(GO:0034599)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010421

hydrogen peroxide-mediated programmed cell death

PMID:24129923[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54E42
UniProtKB:Q54HY5
UniProtKB:Q54LJ4
UniProtKB:Q54X55
UniProtKB:Q55AK6
UniProtKB:Q55GU8
UniProtKB:Q86KC8
UniProtKB:Q8I7C6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903518

positive regulation of single strand break repair

PMID:23750002[9]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8I7C6

P

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:21807880[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031152

aggregation involved in sorocarp development

PMID:21385463[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990404

protein ADP-ribosylase activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1340806
PANTHER:PTN000396992
UniProtKB:P09874
UniProtKB:Q9UGN5

F

Seeded From UniProt

complete

involved_in

GO:0070212

protein poly-ADP-ribosylation

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1340806
PANTHER:PTN000396992
RGD:2053
UniProtKB:P09874
UniProtKB:P26446
WB:WBGene00004049
WB:WBGene00004050
dictyBase:DDB_G0278741
dictyBase:DDB_G0292820

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1340806
MGI:MGI:1891258
PANTHER:PTN000396992
UniProtKB:P09874
UniProtKB:Q9Y6F1
dictyBase:DDB_G0278741
dictyBase:DDB_G0292820

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010247
MGI:MGI:1340806
MGI:MGI:1341112
PANTHER:PTN000396992
UniProtKB:P09874
UniProtKB:Q9UGN5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1340806
MGI:MGI:1341112
PANTHER:PTN000396992
RGD:2053
TAIR:locus:2005523
UniProtKB:P09874
UniProtKB:Q9UGN5
dictyBase:DDB_G0278741
dictyBase:DDB_G0279195
dictyBase:DDB_G0292820

C

Seeded From UniProt

complete

enables

GO:0003950

NAD+ ADP-ribosyltransferase activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010247
MGI:MGI:1340806
MGI:MGI:1341112
PANTHER:PTN000396992
RGD:2053
TAIR:locus:2042511
UniProtKB:P09874
UniProtKB:Q9Y6F1
WB:WBGene00004049
WB:WBGene00004050

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001510
InterPro:IPR036957

F

Seeded From UniProt

complete

enables

GO:0003950

NAD+ ADP-ribosyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004102
InterPro:IPR012317
InterPro:IPR036616

F

Seeded From UniProt

complete

involved_in

GO:0006471

protein ADP-ribosylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004102
InterPro:IPR036616

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001510
InterPro:IPR036957

F

Seeded From UniProt

complete

enables

GO:0003950

NAD+ ADP-ribosyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.2.30

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

enables

GO:0003950

NAD+ ADP-ribosyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078407

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Couto, CA et al. (2011) PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks. J. Cell Biol. 194 367-75 PubMed GONUTS page
  2. Kolb, AL et al. (2017) Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium. Nucleic Acids Res. 45 10056-10067 PubMed GONUTS page
  3. 3.0 3.1 3.2 Rakhimova, A et al. (2017) Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks. Sci Rep 7 43750 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Rajawat, J et al. (2014) Involvement of poly(ADP-ribose) polymerase in paraptotic cell death of D. discoideum. Apoptosis 19 90-101 PubMed GONUTS page
  5. Mir, H et al. (2015) Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase. Cell Prolif. 48 363-74 PubMed GONUTS page
  6. Kofler, B et al. (1993) Purification and characterization of NAD+:ADP-ribosyltransferase (polymerizing) from Dictyostelium discoideum. Biochem. J. 293 ( Pt 1) 275-81 PubMed GONUTS page
  7. 7.0 7.1 Jubin, T et al. () Poly (ADP-ribose) polymerase1 regulates growth and multicellularity in D. discoideum. Differentiation 92 10-23 PubMed GONUTS page
  8. Gunn, AR et al. (2016) The role of ADP-ribosylation in regulating DNA interstrand crosslink repair. J. Cell. Sci. 129 3845-3858 PubMed GONUTS page
  9. Couto, CA et al. (2013) Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks. J. Cell. Sci. 126 3452-61 PubMed GONUTS page
  10. Rajawat, J et al. (2011) Differential role of poly(ADP-ribose) polymerase in D. discoideum growth and development. BMC Dev. Biol. 11 14 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page