GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Category:Team Fanny Pack Eradication
|Status||Page||User||Date/Time||GO Term (Aspect)||Reference||Evidence||Notes||Links|
|KLEP3:APBE1||Drumhel2, Team Fanny Pack Eradication||2013-04-14 11:47:10 CDT||GO:0017013 protein flavinylation (P)||PMID:23558683||ECO:0000314 direct assay evidence used in manual assertion|
|STRMU:NAGB||Drumhel2, Team Fanny Pack Eradication||2013-04-11 10:59:49 CDT||GO:0006040 amino sugar metabolic process (P)||PMID:22438919||ECO:0000314 direct assay evidence used in manual assertion|
Figure 2 shows the addition of N-acetylglucosamine (GlcNAc)increases the expression of NagB but decreases the expression of GlmS, a gene which functionally opposes that of NagB. GlmS is known to be a key factor affecting the entrance of amino sugars into glycolysis and cell wall synthesis in several other bacteria, however their roles in S. mutans remain unclear. This paper, and specifically figure 2, confirms this function in S. mutans as well.
|STRMU:Q8DWM3||Drumhel2, Team Fanny Pack Eradication||2013-04-11 10:04:59 CDT||GO:0044011 single-species biofilm formation on inanimate substrate (P)||PMID:21078847||ECO:0000315 mutant phenotype evidence used in manual assertion|
Fig. 4A/4B shows that biofilm formation on glass surfaces was impaired in GbpB knockdown mutants.
|MOUSE:JAK2||Mcgeedev, Team Fanny Pack Eradication||2013-03-31 10:11:08 CDT||GO:0019221 cytokine-mediated signaling pathway (P)||PMID:23526587||ECO:0000314 direct assay evidence used in manual assertion|
JAK2 is essential to naive t cell homing. Figure 2C demonstrates that silencing JAK1/2 proteins severely inhibited the ability of chemokine-mediated t cell signaling. This indicated by the naive t-cell's inability to migrate through a chemokine gradient.