Category:GO:0045254 ! pyruvate dehydrogenase complex

name: pyruvate dehydrogenase complex
namespace: cellular_component
alt_id: GO:0009364
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:36863425]
comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (acetyl-transferring) activity ; GO:0004739' (E1), 'dihydrolipoyllysine-residue acetyltransferase activity ; GO:0004742' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'pyruvate dehydrogenase (NAD+) activity ; GO:0034604'.
subset: goslim_pir
synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT []
xref: Wikipedia:Pyruvate_dehydrogenase_complex
is_a: GO:0045240 ! alpha-ketoacid dehydrogenase complex

AmiGO <GOterm>GO:0045254</GOterm>
Gene Ontology Home