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HUMAN:ODPX
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PDHX (synonyms: PDX1) | |
| Protein Name(s) | Pyruvate dehydrogenase protein X component, mitochondrial
Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex E3-binding protein E3BP Lipoyl-containing pyruvate dehydrogenase complex component X proX | |
| External Links | ||
| UniProt | O00330 | |
| EMBL | AF001437 Y13145 U82328 AJ298105 AK301384 AC107928 AL138810 AL356215 CH471064 CH471064 BC010389 U79296 | |
| CCDS | CCDS44569.1 CCDS53616.1 CCDS7896.1 | |
| RefSeq | NP_001128496.1 NP_001159630.1 NP_003468.2 | |
| UniGene | Hs.502315 | |
| PDB | 1ZY8 2DNC 2F5Z 2F60 | |
| PDBsum | 1ZY8 2DNC 2F5Z 2F60 | |
| ProteinModelPortal | O00330 | |
| SMR | O00330 | |
| BioGrid | 113737 | |
| DIP | DIP-29026N | |
| IntAct | O00330 | |
| MINT | MINT-1482590 | |
| STRING | 9606.ENSP00000227868 | |
| PhosphoSite | O00330 | |
| MaxQB | O00330 | |
| PaxDb | O00330 | |
| PeptideAtlas | O00330 | |
| PRIDE | O00330 | |
| DNASU | 8050 | |
| Ensembl | ENST00000227868 ENST00000430469 ENST00000448838 | |
| GeneID | 8050 | |
| KEGG | hsa:8050 | |
| UCSC | uc001mvt.3 | |
| CTD | 8050 | |
| GeneCards | GC11P034894 | |
| HGNC | HGNC:21350 | |
| HPA | HPA038484 HPA038485 | |
| MIM | 245349 608769 | |
| neXtProt | NX_O00330 | |
| Orphanet | 255182 | |
| PharmGKB | PA134976445 | |
| eggNOG | COG0508 | |
| GeneTree | ENSGT00760000119281 | |
| HOGENOM | HOG000281566 | |
| HOVERGEN | HBG005063 | |
| InParanoid | O00330 | |
| KO | K13997 | |
| OMA | SWRLGCD | |
| PhylomeDB | O00330 | |
| TreeFam | TF332256 | |
| BioCyc | MetaCyc:ENSG00000110435-MONOMER | |
| Reactome | REACT_12528 REACT_2071 | |
| ChiTaRS | PDHX | |
| EvolutionaryTrace | O00330 | |
| GeneWiki | E3_binding_protein | |
| GenomeRNAi | 8050 | |
| NextBio | 30644 | |
| PRO | PR:O00330 | |
| Proteomes | UP000005640 | |
| Bgee | O00330 | |
| CleanEx | HS_PDHX HS_PDX1 | |
| ExpressionAtlas | O00330 | |
| Genevestigator | O00330 | |
| GO | GO:0005759 GO:0016746 GO:0044237 GO:0006090 GO:0010510 GO:0044281 | |
| Gene3D | 3.30.559.10 4.10.320.10 | |
| InterPro | IPR003016 IPR001078 IPR000089 IPR023213 IPR004167 IPR011053 | |
| Pfam | PF00198 PF00364 PF02817 | |
| SUPFAM | SSF47005 SSF51230 | |
| PROSITE | PS50968 PS00189 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0045254 |
pyruvate dehydrogenase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061732 |
mitochondrial acetyl-CoA biosynthetic process from pyruvate |
ECO:0000305 |
curator inference used in manual assertion |
GO:0034604 |
P |
Seeded From UniProt |
complete | ||
|
Contributes to |
GO:0004738 |
pyruvate dehydrogenase activity |
ECO:0000314 |
F |
Underactivity known to cause brain damage post-stroke |
complete | ||||
|
part_of |
GO:0045254 |
pyruvate dehydrogenase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0034604 |
pyruvate dehydrogenase (NAD+) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006090 |
pyruvate metabolic process |
Reactome:R-HSA-70268 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-71397 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mathias, RA et al. (2014) Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell 159 1615-25 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Harris, RA et al. (1997) Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. J. Biol. Chem. 272 19746-51 PubMed GONUTS page
- ↑ Geng, X et al. (2015) Ethanol and normobaric oxygen: novel approach in modulating pyruvate dehydrogenase complex after severe transient and permanent ischemic stroke. Stroke 46 492-9 PubMed GONUTS page
