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PMID:25563647
| Citation |
Geng, X, Elmadhoun, O, Peng, C, Ji, X, Hafeez, A, Liu, Z, Du, H, Rafols, JA and Ding, Y (2015) Ethanol and normobaric oxygen: novel approach in modulating pyruvate dehydrogenase complex after severe transient and permanent ischemic stroke. Stroke 46:492-9 |
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| Abstract |
Ischemic stroke induces metabolic disarray. A central regulatory site, pyruvate dehydrogeanse complex (PDHC) sits at the cross-roads of 2 fundamental metabolic pathways: aerobic and anaerobic. In this study, we combined ethanol (EtOH) and normobaric oxygen (NBO) to develop a novel treatment to modulate PDHC and its regulatory proteins, namely pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase, leading to improved metabolism and reduced oxidative damage. |
| Links |
PubMed Online version:10.1161/STROKEAHA.114.006994 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0004738: pyruvate dehydrogenase activity |
ECO:0000314: |
F |
Underactivity known to cause brain damage post-stroke |
complete | |||
Notes
See also
References
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