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MYCTU:KGD
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | kgd | |
| Protein Name(s) | Multifunctional 2-oxoglutarate metabolism enzyme
2-hydroxy-3-oxoadipate synthase HOA synthase HOAS 2-oxoglutarate carboxy-lyase 2-oxoglutarate decarboxylase Alpha-ketoglutarate decarboxylase KG decarboxylase KGD Alpha-ketoglutarate-glyoxylate carboligase 2-oxoglutarate dehydrogenase E1 component ODH E1 component Alpha-ketoglutarate dehydrogenase E1 component KDH E1 component Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2-oxoglutarate dehydrogenase complex E2 component ODH E2 component OGDC-E2 Dihydrolipoamide succinyltransferase | |
| External Links | ||
| UniProt | P9WIS5 | |
| EMBL | AL123456 | |
| PIR | G70953 | |
| RefSeq | NP_215764.2 WP_003898790.1 | |
| ProteinModelPortal | P9WIS5 | |
| SMR | P9WIS5 | |
| IntAct | P9WIS5 | |
| STRING | 83332.Rv1248c | |
| EnsemblBacteria | CCP44004 | |
| GeneID | 887084 | |
| KEGG | mtu:Rv1248c mtv:RVBD_1248c | |
| TubercuList | Rv1248c | |
| KO | K01616 | |
| OMA | QNQGAWF | |
| PhylomeDB | P9WIS5 | |
| UniPathway | UPA00223 UPA00223 | |
| Proteomes | UP000001584 | |
| GO | GO:0005618 GO:0005886 GO:0045254 GO:0050439 GO:0008683 GO:0004149 GO:0009055 GO:0000287 GO:0016624 GO:0030976 GO:0006103 GO:0040007 GO:0055114 GO:0006099 | |
| Gene3D | 3.30.559.10 3.40.50.970 | |
| InterPro | IPR001078 IPR011603 IPR023213 IPR001017 IPR029061 IPR005475 | |
| PANTHER | PTHR23152 | |
| Pfam | PF00198 PF00676 PF02779 | |
| PIRSF | PIRSF000157 | |
| SMART | SM00861 | |
| SUPFAM | SSF52518 | |
| TIGRFAMs | TIGR00239 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008683 |
2-oxoglutarate decarboxylase activity |
ECO:0000314 |
F |
complete | ||||||
|
Contributes to |
GO:0030976 |
thiamine pyrophosphate binding |
ECO:0000314 |
F |
Figure 1C |
complete | ||||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045254 |
pyruvate dehydrogenase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009055 |
electron transfer activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0004591 |
oxoglutarate dehydrogenase (succinyl-transferring) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050439 |
2-hydroxy-3-oxoadipate synthase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0008683 |
2-oxoglutarate decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008683 |
2-oxoglutarate decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006103 |
2-oxoglutarate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045252 |
oxoglutarate dehydrogenase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000568360 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000568360 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10979 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004591 |
oxoglutarate dehydrogenase (succinyl-transferring) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10979 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022900 |
electron transport chain |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009055 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016624 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030976 |
thiamine pyrophosphate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050439 |
2-hydroxy-3-oxoadipate synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004149 |
dihydrolipoyllysine-residue succinyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0816 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016831 |
carboxy-lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Tian, J et al. (2005) Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. U.S.A. 102 10670-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Tian, J et al. (2005) Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol. Microbiol. 57 859-68 PubMed GONUTS page
- ↑ Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 de Carvalho, LP et al. (2010) Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chem. Biol. 17 323-32 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0055114 ! obsolete oxidation-reduction process
- GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
- GO:0016491 ! oxidoreductase activity
- GO:0045252 ! oxoglutarate dehydrogenase complex
- GO:0004591 ! oxoglutarate dehydrogenase (succinyl-transferring) activity
