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Category:GO:0045240 ! alpha-ketoacid dehydrogenase complex
name: alpha-ketoacid dehydrogenase complex
namespace: cellular_component
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present." [GOC:mah, PMID:10745006]
synonym: "2-oxoacid dehydrogenase complex" EXACT []
synonym: "dihydrolipoyl dehydrogenase complex" EXACT []
is_a: GO:1990204 ! oxidoreductase complex
AmiGO
<GOterm>GO:0045240</GOterm>
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This category has the following 4 subcategories, out of 4 total.
