GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Category:GO:0005680 ! anaphase-promoting complex
name: anaphase-promoting complex
namespace: cellular_component
def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
synonym: "anaphase promoting complex" EXACT []
synonym: "APC" BROAD []
synonym: "cyclosome" EXACT []
xref: Wikipedia:Anaphase-promoting_complex
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex
AmiGO
<GOterm>GO:0005680</GOterm>
Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Usage Notes
References
See Help:References for how to manage references in GONUTS.
