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CHICK:XRCC6

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) XRCC6 (synonyms: G22P1, KU70)
Protein Name(s) X-ray repair cross-complementing protein 5

5'-deoxyribose-5-phosphate lyase Ku70 5'-dRP/AP lyase Ku70 ATP-dependent DNA helicase 2 subunit 1 ATP-dependent DNA helicase II 70 kDa subunit DNA repair protein XRCC6 Ku autoantigen protein p70 homolog Ku70

External Links
UniProt O93257
EMBL AB016529
RefSeq NP_990258.1
UniGene Gga.26690
ProteinModelPortal O93257
SMR O93257
BioGrid 676041
STRING 9031.ENSGALP00000037185
PaxDb O93257
PRIDE O93257
GeneID 395767
KEGG gga:395767
CTD 2547
eggNOG NOG305318
HOGENOM HOG000006588
HOVERGEN HBG006236
InParanoid O93257
KO K10884
PhylomeDB O93257
Reactome REACT_115694
NextBio 20815835
PRO PR:O93257
Proteomes UP000000539
GO GO:0005694
GO:0043564
GO:0070419
GO:0005654
GO:0051575
GO:0005524
GO:0004003
GO:0003684
GO:0042162
GO:0006310
GO:0006281
GO:0006302
GO:0006303
GO:0045892
GO:0000723
GO:0006351
Gene3D 1.10.1600.10
1.10.720.30
2.40.290.10
3.40.50.410
4.10.970.10
InterPro IPR006165
IPR006164
IPR027388
IPR005160
IPR005161
IPR003034
IPR016194
IPR002035
PANTHER PTHR12604:SF2
Pfam PF02735
PF03730
PF03731
PF02037
PIRSF PIRSF003033
SMART SM00559
SM00513
SUPFAM SSF100939
SSF53300
TIGRFAMs TIGR00578
PROSITE PS50800

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:1990904

ribonucleoprotein complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13010

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13010

F

Seeded From UniProt

complete

involved_in

GO:0071480

cellular response to gamma radiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12956

P

Seeded From UniProt

complete

part_of

GO:0070419

nonhomologous end joining complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12956

C

Seeded From UniProt

complete

enables

GO:0051575

5'-deoxyribose-5-phosphate lyase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12956

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12956

P

Seeded From UniProt

complete

part_of

GO:0043564

Ku70:Ku80 complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12956

C

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12956

P

Seeded From UniProt

complete

involved_in

GO:0071481

cellular response to X-ray

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288287
RGD:2643
RGD:3976

P

Seeded From UniProt

complete

involved_in

GO:0071480

cellular response to gamma radiation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0041627
PANTHER:PTN000288287
UniProtKB:P12956
UniProtKB:P13010

P

Seeded From UniProt

complete

part_of

GO:0043564

Ku70:Ku80 complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011774
PANTHER:PTN000288287
SGD:S000004712
SGD:S000004897
UniProtKB:P12956
UniProtKB:P13010
dictyBase:DDB_G0286069
dictyBase:DDB_G0286303

C

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288287
PomBase:SPBC543.03c
PomBase:SPCC126.02c
SGD:S000004712
UniProtKB:P13010

F

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011774
FB:FBgn0041627
MGI:MGI:95606
PANTHER:PTN000288287
PomBase:SPBC543.03c
PomBase:SPCC126.02c
SGD:S000004712
SGD:S000004897
TAIR:locus:2023757
TAIR:locus:2035495
UniProtKB:P12956
UniProtKB:P13010
UniProtKB:Q4WI96
dictyBase:DDB_G0286303

P

Seeded From UniProt

complete

contributes_to

GO:0003690

double-stranded DNA binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95606
PANTHER:PTN000288287
RGD:2643
RGD:3976
TAIR:locus:2023757
TAIR:locus:2035495

F

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000288287
PomBase:SPBC543.03c
PomBase:SPCC126.02c
SGD:S000004712
UniProtKB:P13010

C

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011774
FB:FBgn0041627
PANTHER:PTN000288287
PomBase:SPBC543.03c
PomBase:SPCC126.02c
SGD:S000004712
SGD:S000004897
TAIR:locus:2035495
UniProtKB:A0A1D8PF81
UniProtKB:Q7F1M0

P

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004003

P

Seeded From UniProt

complete

involved_in

GO:0000723

telomere maintenance

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006165

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005160
InterPro:IPR006164
InterPro:IPR006165

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006165

F

Seeded From UniProt

complete

enables

GO:0004003

ATP-dependent DNA helicase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005160

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006165

C

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005160
InterPro:IPR006164
InterPro:IPR006165

P

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006165

F

Seeded From UniProt

complete

part_of

GO:0043564

Ku70:Ku80 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006165

C

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

Reactome:R-GGA-353423

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-GGA-353313
Reactome:R-GGA-353298
Reactome:R-GGA-353283
Reactome:R-GGA-353226

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page