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CHICK:TBX5

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) TBX5
Protein Name(s) T-box transcription factor TBX5

T-box protein 5

External Links
UniProt Q9PWE8
EMBL AF033671
AF069396
RefSeq NP_989504.1
UniGene Gga.961
ProteinModelPortal Q9PWE8
SMR Q9PWE8
IntAct Q9PWE8
PaxDb Q9PWE8
GeneID 373988
KEGG gga:373988
CTD 6910
eggNOG NOG320009
HOGENOM HOG000286001
HOVERGEN HBG007310
InParanoid Q9PWE8
KO K10179
OrthoDB EOG7GN2PM
PhylomeDB Q9PWE8
TreeFam TF106341
Reactome REACT_198171
NextBio 20813517
PRO PR:Q9PWE8
Proteomes UP000000539
ExpressionAtlas Q9PWE8
GO GO:0005737
GO:0005634
GO:0005667
GO:0003677
GO:0000977
GO:0001228
GO:0043565
GO:0003700
GO:0030262
GO:0060413
GO:0003181
GO:0003166
GO:0003218
GO:0055007
GO:0007267
GO:0035115
GO:0030326
GO:0003197
GO:0007507
GO:0030324
GO:0002009
GO:0060044
GO:0030336
GO:0008285
GO:0007389
GO:0060039
GO:0060045
GO:0051891
GO:0072513
GO:0045893
GO:1900117
GO:0032526
GO:0003229
GO:0003281
Gene3D 2.60.40.820
InterPro IPR008967
IPR001699
IPR018186
PANTHER PTHR11267
Pfam PF00907
PRINTS PR00937
SMART SM00425
SUPFAM SSF49417
PROSITE PS01283
PS01264
PS50252

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

C

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

F

Seeded From UniProt

complete

involved_in

GO:0048513

animal organ development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0035115

embryonic forelimb morphogenesis

PMID:12736216[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

PMID:18160705[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:18160705[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18160705[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:18160705[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q5ZIV8

F

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:12736216[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060174

limb bud formation

PMID:12736216[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0001725

stress fiber

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030274

LIM domain binding

PMID:15302601[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q679P3

F

Seeded From UniProt

complete

enables

GO:0030274

LIM domain binding

PMID:15302601[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:R4GKC8

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:16880269[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

PMID:16880269[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16880269[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000134)
  • part_of:(UBERON:0003859)|part_of:(UBERON:0002348)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16880269[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000134)
  • part_of:(UBERON:0003859)|part_of:(UBERON:0002348)

Seeded From UniProt

complete

enables

GO:0097110

scaffold protein binding

PMID:16880269[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q679P3
UniProtKB:R4GKC8

F

Seeded From UniProt

complete

involved_in

GO:0003281

ventricular septum development

PMID:19727199[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003218

cardiac left ventricle formation

PMID:19727199[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060044

negative regulation of cardiac muscle cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0060039

pericardium development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0051891

positive regulation of cardioblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

F

Seeded From UniProt

complete

involved_in

GO:0035115

embryonic forelimb morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0030326

embryonic limb morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99593

F

Seeded From UniProt

complete

involved_in

GO:0072513

positive regulation of secondary heart field cardioblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0060413

atrial septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0060045

positive regulation of cardiac muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0055007

cardiac muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0035136

forelimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0035115

embryonic forelimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0030326

embryonic limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

F

Seeded From UniProt

complete

involved_in

GO:0003283

atrial septum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0003281

ventricular septum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0003229

ventricular cardiac muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0003218

cardiac left ventricle formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0003197

endocardial cushion development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0003181

atrioventricular valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0003166

bundle of His development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

involved_in

GO:0002009

morphogenesis of an epithelium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70326
ensembl:ENSMUSP00000018407

F

Seeded From UniProt

complete

involved_in

GO:0060044

negative regulation of cardiac muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0060039

pericardium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0051891

positive regulation of cardioblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

F

Seeded From UniProt

complete

involved_in

GO:0035136

forelimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0035115

embryonic forelimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

C

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0030326

embryonic limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

F

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99593
ensembl:ENSP00000309913

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001699
InterPro:IPR008967
InterPro:IPR018186
InterPro:IPR036960

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001699
InterPro:IPR018186
InterPro:IPR036960

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001699
InterPro:IPR008967
InterPro:IPR018186
InterPro:IPR036960

P

Seeded From UniProt

complete

involved_in

GO:0060173

limb development

PMID:15302601[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035137

hindlimb morphogenesis

PMID:15302601[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

PMID:14511757[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:12508222[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Takeuchi, JK et al. (2003) Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade. Development 130 2729-39 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Krause, A et al. (2004) Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev. Biol. 273 106-20 PubMed GONUTS page
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