GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CHICK:TBX5
Contents
Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
Gene Name(s) | TBX5 | |
Protein Name(s) | T-box transcription factor TBX5
T-box protein 5 | |
External Links | ||
UniProt | Q9PWE8 | |
EMBL | AF033671 AF069396 | |
RefSeq | NP_989504.1 | |
UniGene | Gga.961 | |
ProteinModelPortal | Q9PWE8 | |
SMR | Q9PWE8 | |
IntAct | Q9PWE8 | |
PaxDb | Q9PWE8 | |
GeneID | 373988 | |
KEGG | gga:373988 | |
CTD | 6910 | |
eggNOG | NOG320009 | |
HOGENOM | HOG000286001 | |
HOVERGEN | HBG007310 | |
InParanoid | Q9PWE8 | |
KO | K10179 | |
OrthoDB | EOG7GN2PM | |
PhylomeDB | Q9PWE8 | |
TreeFam | TF106341 | |
Reactome | REACT_198171 | |
NextBio | 20813517 | |
PRO | PR:Q9PWE8 | |
Proteomes | UP000000539 | |
ExpressionAtlas | Q9PWE8 | |
GO | GO:0005737 GO:0005634 GO:0005667 GO:0003677 GO:0000977 GO:0001228 GO:0043565 GO:0003700 GO:0030262 GO:0060413 GO:0003181 GO:0003166 GO:0003218 GO:0055007 GO:0007267 GO:0035115 GO:0030326 GO:0003197 GO:0007507 GO:0030324 GO:0002009 GO:0060044 GO:0030336 GO:0008285 GO:0007389 GO:0060039 GO:0060045 GO:0051891 GO:0072513 GO:0045893 GO:1900117 GO:0032526 GO:0003229 GO:0003281 | |
Gene3D | 2.60.40.820 | |
InterPro | IPR008967 IPR001699 IPR018186 | |
PANTHER | PTHR11267 | |
Pfam | PF00907 | |
PRINTS | PR00937 | |
SMART | SM00425 | |
SUPFAM | SSF49417 | |
PROSITE | PS01283 PS01264 PS50252 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048513 |
animal organ development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035115 |
embryonic forelimb morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005884 |
actin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0051087 |
chaperone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060174 |
limb bud formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0001725 |
stress fiber |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0030274 |
LIM domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030274 |
LIM domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005884 |
actin filament |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
enables |
GO:0097110 |
scaffold protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003281 |
ventricular septum development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003218 |
cardiac left ventricle formation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060044 |
negative regulation of cardiac muscle cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060039 |
pericardium development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051891 |
positive regulation of cardioblast differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035115 |
embryonic forelimb morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030326 |
embryonic limb morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007507 |
heart development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072513 |
positive regulation of secondary heart field cardioblast proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060413 |
atrial septum morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055007 |
cardiac muscle cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035136 |
forelimb morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035115 |
embryonic forelimb morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030326 |
embryonic limb morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030324 |
lung development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007507 |
heart development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007389 |
pattern specification process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003283 |
atrial septum development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003281 |
ventricular septum development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003229 |
ventricular cardiac muscle tissue development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003218 |
cardiac left ventricle formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003197 |
endocardial cushion development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003181 |
atrioventricular valve morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003166 |
bundle of His development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002009 |
morphogenesis of an epithelium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P70326 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060044 |
negative regulation of cardiac muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060039 |
pericardium development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051891 |
positive regulation of cardioblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035136 |
forelimb morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035115 |
embryonic forelimb morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030326 |
embryonic limb morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007507 |
heart development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99593 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001699 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001699 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060173 |
limb development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035137 |
hindlimb morphogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032526 |
response to retinoic acid |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007507 |
heart development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Takeuchi, JK et al. (2003) Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade. Development 130 2729-39 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Krause, A et al. (2004) Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev. Biol. 273 106-20 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Kulisz, A & Simon, HG (2008) An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor. Mol. Cell. Biol. 28 1553-64 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Camarata, T et al. (2006) LMP4 regulates Tbx5 protein subcellular localization and activity. J. Cell Biol. 174 339-48 PubMed GONUTS page
- ↑ 5.0 5.1 Koshiba-Takeuchi, K et al. (2009) Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature 461 95-8 PubMed GONUTS page
- ↑ Yazawa, S et al. (2003) Gene expression of FK506-binding proteins 12.6 and 12 during chicken development. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136 391-9 PubMed GONUTS page
- ↑ Yazawa, S et al. (2003) Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development. Dev. Dyn. 226 33-41 PubMed GONUTS page
a
c
d
e
l
n
p
- GO:0007389 ! pattern specification process
- GO:0060039 ! pericardium development
- Phasianidae
- Phasianinae
- GO:0051891 ! positive regulation of cardioblast differentiation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0060045 ! positive regulation of cardiac muscle cell proliferation
- GO:0032991 ! protein-containing complex
- GO:0032993 ! protein-DNA complex
- GO:0051087 ! protein-folding chaperone binding
r
- GO:0010468 ! regulation of gene expression
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0032526 ! response to retinoic acid
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
s