CHICK:SRC

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SRC
Protein Name(s)	Proto-oncogene tyrosine-protein kinase Src Proto-oncogene c-Src pp60c-src p60-Src
External Links
UniProt	P00523
EMBL	V00402 J00908 M57290 S43604 S43616 S43587 S43609 S43614 S43579
PIR	A00630
RefSeq	NP_990788.2
UniGene	Gga.46254 Gga.51508 Gga.9406
PDB	1F1W 1F2F 1NLO 1NLP 1P13 1PRL 1PRM 1RLP 1RLQ 1SRL 1SRM 2HWO 2HWP 2OIQ 2PTK 2QI8 2QLQ 2QQ7 3D7T 3D7U 3DQW 3DQX 3EL7 3EL8 3EN4 3EN5 3EN6 3EN7 3F3T 3F3U 3F3V 3F3W 3F6X 3FJ5 3G5D 3G6G 3G6H 3GEQ 3LOK 3OEZ 3OF0 3QLF 3QLG 3SVV 3TZ7 3TZ8 3TZ9 3U4W 3U51 3UQF 3UQG 4AGW 4DGG 4FIC 4HVU 4HVV 4HVW 4JZ3 4JZ4 4LE9 4LGG 4LGH 4MCV 4U5J
PDBsum	1F1W 1F2F 1NLO 1NLP 1P13 1PRL 1PRM 1RLP 1RLQ 1SRL 1SRM 2HWO 2HWP 2OIQ 2PTK 2QI8 2QLQ 2QQ7 3D7T 3D7U 3DQW 3DQX 3EL7 3EL8 3EN4 3EN5 3EN6 3EN7 3F3T 3F3U 3F3V 3F3W 3F6X 3FJ5 3G5D 3G6G 3G6H 3GEQ 3LOK 3OEZ 3OF0 3QLF 3QLG 3SVV 3TZ7 3TZ8 3TZ9 3U4W 3U51 3UQF 3UQG 4AGW 4DGG 4FIC 4HVU 4HVV 4HVW 4JZ3 4JZ4 4LE9 4LGG 4LGH 4MCV 4U5J
ProteinModelPortal	P00523
SMR	P00523
BioGrid	676691
DIP	DIP-449N
IntAct	P00523
MINT	MINT-139173
BindingDB	P00523
ChEMBL	CHEMBL3655
PaxDb	P00523
Ensembl	ENSGALT00000006127
GeneID	396442
KEGG	gga:396442
CTD	6714
eggNOG	COG0515
GeneTree	ENSGT00760000118938
HOVERGEN	HBG008761
InParanoid	P00523
KO	K05704
OMA	CHRLTNV
OrthoDB	EOG7GTT2V
PhylomeDB	P00523
TreeFam	TF351634
BRENDA	2.7.10.2
Reactome	REACT_189763 REACT_194391 REACT_196766 REACT_204997 REACT_207020 REACT_217737 REACT_220416 REACT_226416 REACT_230783 REACT_235751 REACT_239556 REACT_240004 REACT_240643 REACT_241087 REACT_246174 REACT_246236 REACT_246525 REACT_248632 REACT_250039 REACT_250385 REACT_252845 REACT_253490 REACT_253932 REACT_254941 REACT_257494 REACT_257604 REACT_262164
EvolutionaryTrace	P00523
NextBio	20816483
PRO	PR:P00523
Proteomes	UP000000539
ExpressionAtlas	P00523
GO	GO:0005901 GO:0005856 GO:0005829 GO:0010008 GO:0070062 GO:0005770 GO:0005764 GO:0005743 GO:0005634 GO:0005524 GO:0020037 GO:0004715 GO:0019903 GO:0007155 GO:0007049 GO:0016477 GO:0030900 GO:0002376 GO:0035556 GO:2000811 GO:0043154 GO:2001237 GO:2001243 GO:0051902 GO:0032463 GO:0048477 GO:0090263 GO:0071803 GO:0051897 GO:0046777 GO:0033146 GO:0043393 GO:0070555 GO:0060065
Gene3D	3.30.505.10
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0071253	connexin binding	PMID:14699011^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08050	F	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15492000^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0071253	connexin binding	PMID:15492000^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08050	F	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12931	F	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:15696169^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17706-2	F	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12003	C	Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	P	Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	P	Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	F	Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 RGD:620795	P	Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98397 PANTHER:PTN000701142	P	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:Q9H3Y6 WB:WBGene00005077	P	Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98397 PANTHER:PTN000701142	P	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P08631	C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 RGD:621423	P	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 RGD:620795	P	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P07948	P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262733 PANTHER:PTN002521528 RGD:2641 RGD:620795 RGD:621017 UniProtKB:P12931	F	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95527 PANTHER:PTN002521528 UniProtKB:P09769 UniProtKB:P51451 UniProtKB:Q13882 WB:WBGene00005077	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11466320^[5]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-GGA-3928596 Reactome:R-GGA-3928593 Reactome:R-GGA-3928579	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page
↑ ^2.0 ^2.1 Sorgen, PL et al. (2004) Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J. Biol. Chem. 279 54695-701 PubMed GONUTS page
↑ van Vliet, C et al. (2005) Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat. Immunol. 6 253-60 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kalo, MS et al. (2001) In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue. J. Biol. Chem. 276 38940-8 PubMed GONUTS page

[PMID:14699011-1] Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page

[PMID:15492000-2] 2.0 ^2.1 Sorgen, PL et al. (2004) Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J. Biol. Chem. 279 54695-701 PubMed GONUTS page

[PMID:15696169-3] van Vliet, C et al. (2005) Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat. Immunol. 6 253-60 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11466320-5] Kalo, MS et al. (2001) In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue. J. Biol. Chem. 276 38940-8 PubMed GONUTS page

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CHICK:SRC

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