CHICK:Q5D212

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	No Information Provided.
Protein Name(s)	Hairy and enhancer of split 5 (ECO:0000313 with EMBL:AAX13956.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000001713)
External Links
UniProt	Q5D212
EMBL	AADN03007983 AY916777
RefSeq	NP_001012713.1
UniGene	Gga.11242
STRING	9031.ENSGALP00000001713
Ensembl	ENSGALT00000001715
GeneID	419392
KEGG	gga:419392
CTD	388585
eggNOG	NOG83691
GeneTree	ENSGT00700000104168
HOGENOM	HOG000236346
HOVERGEN	HBG005960
KO	K06055
OMA	NRLRKPI
OrthoDB	EOG7GN2PQ
PhylomeDB	Q5D212
TreeFam	TF351373
NextBio	20822454
Proteomes	UP000000539
GO	GO:0005634 GO:0003677 GO:0001078 GO:0048708 GO:0042668 GO:0043010 GO:0051216 GO:0007155 GO:0048469 GO:0022010 GO:0072049 GO:0021781 GO:0072282 GO:0048712 GO:2000981 GO:0048715 GO:2000737 GO:0021915 GO:0097150 GO:0007219 GO:0030513 GO:0045747 GO:0048661 GO:0045944 GO:0042517 GO:0006461 GO:0031641 GO:0072050 GO:0007224 GO:0072086 GO:0021537
Gene3D	4.10.280.10
InterPro	IPR011598 IPR003650
Pfam	PF07527 PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888 PS51054

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:1990837	sequence-specific double-stranded DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002609 FB:FBgn0002633 FB:FBgn0002733 FB:FBgn0002734 FB:FBgn0002735 FB:FBgn0010109 PANTHER:PTN000105427	F	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104853 MGI:MGI:104876 MGI:MGI:104877 PANTHER:PTN000105428 ZFIN:ZDB-GENE-980526-144	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000591 FB:FBgn0002609 FB:FBgn0002631 FB:FBgn0002633 FB:FBgn0002733 FB:FBgn0002734 FB:FBgn0002735 FB:FBgn0010109 MGI:MGI:1341800 MGI:MGI:1341884 MGI:MGI:1860511 PANTHER:PTN000105427 RGD:62081 SGD:S000001930 UniProtKB:Q9UBP5	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859852 PANTHER:PTN000105428	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001168 FB:FBgn0002633 FB:FBgn0002735 MGI:MGI:1341884 PANTHER:PTN000105427 RGD:62081	F	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010109 MGI:MGI:104853 MGI:MGI:104876 MGI:MGI:1341800 MGI:MGI:1341884 MGI:MGI:2135679 PANTHER:PTN000105428 RGD:621403 RGD:621405 UniProtKB:Q14469 UniProtKB:Q5TA89 UniProtKB:Q9NQ87 UniProtKB:Q9Y5J3	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002631 FB:FBgn0002733 FB:FBgn0002735 FB:FBgn0010109 FB:FBgn0027788 FB:FBgn0259938 MGI:MGI:104853 MGI:MGI:1097714 MGI:MGI:1341800 MGI:MGI:1341884 MGI:MGI:3040955 PANTHER:PTN000105427 RGD:621403 RGD:621405 RGD:68439 SGD:S000001930 UniProtKB:O14503 UniProtKB:Q14469 UniProtKB:Q9NQ87	C	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097714 MGI:MGI:1860511 MGI:MGI:1930704 PANTHER:PTN000105427 UniProtKB:O14503 UniProtKB:Q9C0J9 UniProtKB:Q9NQ87	F	Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135679 PANTHER:PTN000105429 ZFIN:ZDB-GENE-030707-2 ZFIN:ZDB-GENE-040824-5 ZFIN:ZDB-GENE-980526-125	P	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859852 MGI:MGI:2135679 PANTHER:PTN000105427	F	Seeded From UniProt	complete
involved_in	GO:2000981	negative regulation of inner ear receptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0090162	establishment of epithelial cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0072282	metanephric nephron tubule morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0072086	specification of loop of Henle identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0072050	S-shaped body morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0072049	comma-shaped body morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0060122	inner ear receptor cell stereocilium organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0050678	regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0048715	negative regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0048712	negative regulation of astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045607	regulation of inner ear auditory receptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0042668	auditory receptor cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0042491	inner ear auditory receptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0031641	regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0022010	central nervous system myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0021781	glial cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0014003	oligodendrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70120 ensembl:ENSMUSP00000051118	P	Seeded From UniProt	complete
involved_in	GO:2000737	negative regulation of stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TA89 ensembl:ENSP00000367714	P	Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TA89 ensembl:ENSP00000367714	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TA89 ensembl:ENSP00000367714	P	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TA89 ensembl:ENSP00000367714	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TA89 ensembl:ENSP00000367714	P	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5TA89 ensembl:ENSP00000367714	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003650	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003650	P	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q5D212

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