CHICK:FEN1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	FEN1 (ECO:0000255 with HAMAP-Rule:MF_03140)
Protein Name(s)	Flap endonuclease 1 (ECO:0000255 with HAMAP-Rule:MF_03140) FEN-1 (ECO:0000255 with HAMAP-Rule:MF_03140) Flap structure-specific endonuclease 1 (ECO:0000255 with HAMAP-Rule:MF_03140)
External Links
UniProt	Q5ZLN4
EMBL	AB058602 AJ719700
RefSeq	NP_001072959.1
UniGene	Gga.4353
ProteinModelPortal	Q5ZLN4
SMR	Q5ZLN4
BioGrid	690400
STRING	9031.ENSGALP00000005724
PaxDb	Q5ZLN4
PRIDE	Q5ZLN4
Ensembl	ENSGALT00000005734
GeneID	769677
KEGG	gga:769677
CTD	2237
eggNOG	COG0258
GeneTree	ENSGT00640000091478
HOGENOM	HOG000193853
HOVERGEN	HBG000844
InParanoid	Q5ZLN4
KO	K04799
OMA	GSQDYDS
OrthoDB	EOG72JWHG
PhylomeDB	Q5ZLN4
TreeFam	TF105701
Reactome	REACT_252616
NextBio	20919905
PRO	PR:Q5ZLN4
Proteomes	UP000000539
GO	GO:0016020 GO:0005739 GO:0005730 GO:0005654 GO:0008409 GO:0017108 GO:0003677 GO:0000287 GO:0030145 GO:0004523 GO:0006284 GO:0043137
Gene3D	3.40.50.1010
HAMAP	MF_00614
InterPro	IPR020045 IPR023426 IPR008918 IPR029060 IPR006086 IPR019974 IPR006085
Pfam	PF00867 PF00752
SMART	SM00279 SM00484 SM00485
SUPFAM	SSF47807 SSF88723
PROSITE	PS00841 PS00842

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0048256	flap endonuclease activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263831 MGI:MGI:102779 PANTHER:PTN000118612 PomBase:SPAC3G6.06c SGD:S000001596 SGD:S000005559 UniProtKB:P39748 UniProtKB:Q17RS7 UniProtKB:Q64MA3 UniProtKB:Q7K734 UniProtKB:Q9UQ84 WB:WBGene00000794	F	Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102779 PANTHER:PTN000871763	F	Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263831 PANTHER:PTN000118612 PomBase:SPAC3G6.06c SGD:S000001596 SGD:S000005559 UniProtKB:P39748 UniProtKB:Q17RS7	F	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000118791 PomBase:SPAC3G6.06c SGD:S000001596 UniProtKB:P39748	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000118792 RGD:621821 SGD:S000000843 SGD:S000001596 UniProtKB:P39748 WB:WBGene00000794	C	Seeded From UniProt	complete
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000871763 UniProtKB:P39748	F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102779 PANTHER:PTN000871763	F	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004523	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	P	Seeded From UniProt	complete
enables	GO:0048256	flap endonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	F	Seeded From UniProt	complete
involved_in	GO:0045876	positive regulation of sister chromatid cohesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	P	Seeded From UniProt	complete
involved_in	GO:0043137	DNA replication, removal of RNA primer	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	F	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
enables	GO:0004523	RNA-DNA hybrid ribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	F	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39748 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6FHX6 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6FHX6 ensembl:ENSP00000305480	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002421 InterPro:IPR008918	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008918	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006084 InterPro:IPR006085 InterPro:IPR006086	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006084 InterPro:IPR006085	P	Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019974 InterPro:IPR023426	F	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	F	Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	P	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	F	Seeded From UniProt	complete
involved_in	GO:0043137	DNA replication, removal of RNA primer	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	P	Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000337265	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:FEN1

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