CHICK:FAK1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	PTK2 (synonyms: FAK, FAK1)
Protein Name(s)	Focal adhesion kinase 1 FADK 1 Focal adhesion kinase-related nonkinase FRNK p41/p43FRNK Protein-tyrosine kinase 2 p125FAK pp125FAK
External Links
UniProt	Q00944
EMBL	M86656 L08402
PIR	A45388 PC1239
RefSeq	NP_990766.1
UniGene	Gga.15614
PDB	1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKM 2JKO 2JKQ 2L6F 2L6G 2L6H 3ZDT 4BRX 4C7T 4CYE 4D4R 4D4S 4D4V 4D4Y 4D55 4D58 4D5H 4D5K
PDBsum	1KTM 1PV3 1QVX 2AEH 2AL6 2J0J 2J0K 2J0L 2J0M 2JKK 2JKM 2JKO 2JKQ 2L6F 2L6G 2L6H 3ZDT 4BRX 4C7T 4CYE 4D4R 4D4S 4D4V 4D4Y 4D55 4D58 4D5H 4D5K
ProteinModelPortal	Q00944
SMR	Q00944
BioGrid	676665
IntAct	Q00944
MINT	MINT-1517788
STRING	9031.ENSGALP00000026014
PaxDb	Q00944
PRIDE	Q00944
Ensembl	ENSGALT00000026060
GeneID	396416
KEGG	gga:396416
CTD	5747
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000069938
HOVERGEN	HBG004018
InParanoid	Q00944
KO	K05725
OMA	MVQTNHY
PhylomeDB	Q00944
BRENDA	2.7.10.2
Reactome	REACT_274339 REACT_277627 REACT_286768 REACT_288770 REACT_299011 REACT_304572 REACT_321609 REACT_329539 REACT_331956 REACT_337978 REACT_350963 REACT_357253
EvolutionaryTrace	Q00944
NextBio	20816457
PRO	PR:Q00944
Proteomes	UP000000539
ExpressionAtlas	Q00944
GO	GO:0031234 GO:0005925 GO:0005815 GO:0005634 GO:0048471 GO:0005524 GO:0042802 GO:0004715 GO:0004713 GO:0005102 GO:0004871 GO:0001525 GO:0007155 GO:0030154 GO:0016477 GO:0007010 GO:0007173 GO:0045087 GO:0043066 GO:0038083 GO:0018108 GO:0030155 GO:0042127 GO:0007172
InterPro	IPR019749 IPR019748 IPR000299 IPR005189 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR029071
Pfam	PF00373 PF03623 PF07714
PRINTS	PR00109
ProDom	PD006413
SMART	SM00295 SM00219
SUPFAM	SSF47031 SSF54236 SSF56112 SSF68993
PROSITE	PS00661 PS50057 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15340073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:15340073^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E1BR22	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:15340073^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B6V3H8	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:15340073^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92178	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1594631^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:1594631^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	PMID:23393139^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031953	negative regulation of protein autophosphorylation	PMID:23393139^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	PMID:23393139^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:23393139^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:10454559^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001134)\|part_of:(UBERON:0002107)\|part_of:(UBERON:0000948)\|part_of:(UBERON:0002048)\|part_of:(UBERON:0000160)\|part_of:(UBERON:0000955)\|part_of:(UBERON:0000970)	Seeded From UniProt	complete
involved_in	GO:0060055	angiogenesis involved in wound healing	PMID:15537495^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002139)	Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	PMID:10409118^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001112) occurs_in:(CL:0000187)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:10409118^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001112) occurs_in:(CL:0000187)\|occurs_in:(CL:0002372) occurs_in:(CL:0000515)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10409118^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001112) part_of:(CL:0000187)	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:10409118^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001112) part_of:(CL:0000187)	Seeded From UniProt	complete
involved_in	GO:0021852	pyramidal neuron migration	PMID:21832197^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005343)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:23393139^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700474 RGD:3443 RGD:628758	C		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87859 PANTHER:PTN001975310 UniProtKB:Q05397	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001975310 RGD:628758 UniProtKB:P00519 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231249 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001975310 RGD:628758	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231249 RGD:628758	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN002400754 RGD:3443 RGD:628758 UniProtKB:Q00944 UniProtKB:Q05397 UniProtKB:Q14289	C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000017 MGI:MGI:104908 MGI:MGI:1930958 MGI:MGI:95481 PANTHER:PTN001975310 UniProtKB:P00519 UniProtKB:Q05397 UniProtKB:Q14289 WB:WBGene00002213	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001231249 RGD:628758	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20802513^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00944	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17721515^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00944	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004198	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR020635 InterPro:IPR036137	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000299	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR036137	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR005189 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR036137	P		Seeded From UniProt	complete
involved_in	GO:0007172	signal complex assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR036137	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:10454559^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001134)\|part_of:(UBERON:0002048)\|part_of:(UBERON:0000160)	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:17604018^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07228	F	occurs_in:(CL:0000134)	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:17604018^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:F1N8N7	F	occurs_in:(CL:0000134)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1NJW4	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1NJW1	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Westhoff, MA et al. (2004) SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Mol. Cell. Biol. 24 8113-33 PubMed GONUTS page
↑ ^2.0 ^2.1 Schaller, MD et al. (1992) pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. U.S.A. 89 5192-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Ritt, M et al. (2013) Visualizing and manipulating focal adhesion kinase regulation in live cells. J. Biol. Chem. 288 8875-86 PubMed GONUTS page
↑ ^4.0 ^4.1 Nolan, K et al. (1999) Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Mol. Cell. Biol. 19 6120-9 PubMed GONUTS page
↑ Peng, X et al. (2004) Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc. Res. 64 421-30 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Flück, M et al. (1999) Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle. Am. J. Physiol. 277 C152-62 PubMed GONUTS page
↑ Valiente, M et al. (2011) Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26. J. Neurosci. 31 11678-91 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chen, TH et al. (2011) Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition. Oncogene 30 153-66 PubMed GONUTS page
↑ Serrels, B et al. (2007) Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat. Cell Biol. 9 1046-56 PubMed GONUTS page
↑ ^11.0 ^11.1 Jin, EJ et al. (2007) MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev. Biol. 308 474-84 PubMed GONUTS page

[PMID:15340073-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Westhoff, MA et al. (2004) SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Mol. Cell. Biol. 24 8113-33 PubMed GONUTS page

[PMID:1594631-2] 2.0 ^2.1 Schaller, MD et al. (1992) pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. U.S.A. 89 5192-6 PubMed GONUTS page

[PMID:23393139-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Ritt, M et al. (2013) Visualizing and manipulating focal adhesion kinase regulation in live cells. J. Biol. Chem. 288 8875-86 PubMed GONUTS page

[PMID:10454559-4] 4.0 ^4.1 Nolan, K et al. (1999) Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Mol. Cell. Biol. 19 6120-9 PubMed GONUTS page

[PMID:15537495-5] Peng, X et al. (2004) Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc. Res. 64 421-30 PubMed GONUTS page

[PMID:10409118-6] 6.0 ^6.1 ^6.2 ^6.3 Flück, M et al. (1999) Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle. Am. J. Physiol. 277 C152-62 PubMed GONUTS page

[PMID:21832197-7] Valiente, M et al. (2011) Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26. J. Neurosci. 31 11678-91 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20802513-9] Chen, TH et al. (2011) Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition. Oncogene 30 153-66 PubMed GONUTS page

[PMID:17721515-10] Serrels, B et al. (2007) Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat. Cell Biol. 9 1046-56 PubMed GONUTS page

[PMID:17604018-11] 11.0 ^11.1 Jin, EJ et al. (2007) MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction. Dev. Biol. 308 474-84 PubMed GONUTS page

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CHICK:FAK1

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