CANAL:BCR1

Species (Taxon ID)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). (237561)
Gene Name(s)	BCR1 (synonyms: USV1)
Protein Name(s)	Biofilm and cell wall regulator 1
External Links
UniProt	Q59U10
EMBL	AACQ01000135 AACQ01000134
RefSeq	XP_713082.1 XP_713105.1
ProteinModelPortal	Q59U10
GeneID	3645243 3645280
KEGG	cal:CaO19.723 cal:CaO19.8342
CGD	CAL0001773
eggNOG	COG5048
InParanoid	Q59U10
OrthoDB	EOG72JWV8
Proteomes	UP000000559
GO	GO:0000790 GO:0046872 GO:0043565 GO:0003700 GO:0036164 GO:0030447 GO:0044117 GO:1900189 GO:0010811 GO:0044128 GO:0045944 GO:1900228 GO:1900231 GO:0006357 GO:0006355 GO:0044407 GO:0044011
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1900231	regulation of single-species biofilm formation on inanimate substrate	PMID:23563485^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900231	regulation of single-species biofilm formation on inanimate substrate	PMID:22265407^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900231	regulation of single-species biofilm formation on inanimate substrate	PMID:16839200^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900231	regulation of single-species biofilm formation on inanimate substrate	PMID:15964282^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900228	regulation of single-species biofilm formation in or on host organism	PMID:21283544^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900189	positive regulation of cell adhesion involved in single-species biofilm formation	PMID:22359502^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15964282^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044407	single-species biofilm formation in or on host organism	PMID:21283544^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044128	positive regulation of growth of symbiont in host	PMID:22544909^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044117	growth of symbiont in host	PMID:22544909^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:23637598^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:22359502^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:22265407^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:16839200^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044011	single-species biofilm formation on inanimate substrate	PMID:15964282^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:22265407^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0036164	cell-abiotic substrate adhesion	PMID:23572557^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030447	filamentous growth	PMID:20041210^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030447	filamentous growth	PMID:19779551^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010811	positive regulation of cell-substrate adhesion	PMID:22359502^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:22359502^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:22265407^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:16839200^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15964282^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22265407^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Srikantha, T et al. (2013) Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms. Eukaryotic Cell 12 875-88 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nobile, CJ et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148 126-38 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nobile, CJ et al. (2006) Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog. 2 e63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Nobile, CJ & Mitchell, AP (2005) Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr. Biol. 15 1150-5 PubMed GONUTS page
↑ ^5.0 ^5.1 Dwivedi, P et al. (2011) Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and neutrophil evasion. PLoS ONE 6 e16218 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Finkel, JS et al. (2012) Portrait of Candida albicans adherence regulators. PLoS Pathog. 8 e1002525 PubMed GONUTS page
↑ ^7.0 ^7.1 Fanning, S et al. (2012) Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo. Eukaryotic Cell 11 896-904 PubMed GONUTS page
↑ Lin, CH et al. (2013) Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans. PLoS Pathog. 9 e1003305 PubMed GONUTS page
↑ Desai, JV et al. (2013) Regulatory role of glycerol in Candida albicans biofilm formation. MBio 4 e00637-12 PubMed GONUTS page
↑ Homann, OR et al. (2009) A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 5 e1000783 PubMed GONUTS page
↑ Elson, SL et al. (2009) An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 5 e1000664 PubMed GONUTS page

[PMID:23563485-1] Srikantha, T et al. (2013) Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms. Eukaryotic Cell 12 875-88 PubMed GONUTS page

[PMID:22265407-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Nobile, CJ et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148 126-38 PubMed GONUTS page

[PMID:16839200-3] 3.0 ^3.1 ^3.2 Nobile, CJ et al. (2006) Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog. 2 e63 PubMed GONUTS page

[PMID:15964282-4] 4.0 ^4.1 ^4.2 ^4.3 Nobile, CJ & Mitchell, AP (2005) Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr. Biol. 15 1150-5 PubMed GONUTS page

[PMID:21283544-5] 5.0 ^5.1 Dwivedi, P et al. (2011) Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and neutrophil evasion. PLoS ONE 6 e16218 PubMed GONUTS page

[PMID:22359502-6] 6.0 ^6.1 ^6.2 ^6.3 Finkel, JS et al. (2012) Portrait of Candida albicans adherence regulators. PLoS Pathog. 8 e1002525 PubMed GONUTS page

[PMID:22544909-7] 7.0 ^7.1 Fanning, S et al. (2012) Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo. Eukaryotic Cell 11 896-904 PubMed GONUTS page

[PMID:23637598-8] Lin, CH et al. (2013) Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans. PLoS Pathog. 9 e1003305 PubMed GONUTS page

[PMID:23572557-9] Desai, JV et al. (2013) Regulatory role of glycerol in Candida albicans biofilm formation. MBio 4 e00637-12 PubMed GONUTS page

[PMID:20041210-10] Homann, OR et al. (2009) A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 5 e1000783 PubMed GONUTS page

[PMID:19779551-11] Elson, SL et al. (2009) An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 5 e1000664 PubMed GONUTS page

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CANAL:BCR1

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