CAEEL:SKN1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	skn-1
Protein Name(s)	Protein skinhead-1
External Links
UniProt	P34707
EMBL	FO080233 FO080233 FO080233 M84359
PIR	A42143 F88694
RefSeq	NP_741404.1 NP_741405.1 NP_741406.1
UniGene	Cel.23037
PDB	1SKN
PDBsum	1SKN
ProteinModelPortal	P34707
SMR	P34707
BioGrid	42465
IntAct	P34707
MINT	MINT-1094083
BindingDB	P34707
ChEMBL	CHEMBL2146298
PaxDb	P34707
PRIDE	P34707
EnsemblMetazoa	T19E7.2a
GeneID	177343
KEGG	cel:CELE_T19E7.2
UCSC	T19E7.2b
CTD	177343
WormBase	T19E7.2a T19E7.2b T19E7.2c
eggNOG	NOG309753
GeneTree	ENSGT00510000052725
HOGENOM	HOG000021747
InParanoid	P34707
OMA	GLRWRDD
SignaLink	P34707
EvolutionaryTrace	P34707
NextBio	896360
Proteomes	UP000001940
GO	GO:0005783 GO:0005739 GO:0005634 GO:0030544 GO:0000977 GO:0043565 GO:0003700 GO:0001708 GO:0008340 GO:0009880 GO:0001714 GO:0048382 GO:0007275 GO:1900409 GO:0045944 GO:0061408 GO:0006990 GO:0009408 GO:0006979 GO:0000303 GO:0006351
Gene3D	1.10.880.10
InterPro	IPR004827 IPR004826 IPR008917
Pfam	PF03131
SUPFAM	SSF47454
PROSITE	PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0008340	determination of adult lifespan	PMID:19783783^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q94125	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:19783783^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P48376	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:19783783^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9U298	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:19783783^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q19569	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:19783783^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P34271	P		Seeded From UniProt	complete
involved_in	GO:1901562	response to paraquat	PMID:19783783^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P34271	P		Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	PMID:25819561^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5EFV3	P		Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:16166371^[3]	ECO:0000314			C		figure 2	complete CACAO 6993
involved_in	GO:0048566	embryonic digestive tract development	PMID:25819561^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	PMID:25819561^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9XVI2	P		Seeded From UniProt	complete
involved_in	GO:1905804	positive regulation of cellular response to manganese ion	PMID:23721876^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10299	P		Seeded From UniProt	complete
involved_in	GO:0001714	endodermal cell fate specification	PMID:25819561^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905804	positive regulation of cellular response to manganese ion	PMID:23721876^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23721876^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10299)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:23721876^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10299	P	happens_during:(GO:0071287)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:23721876^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071287)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25688864^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(WB:WBGene00019698) occurs_in:(WBbt:0005772)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9303538^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16166371^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:24453991^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(WB:WBGene00006412)	Seeded From UniProt	complete
involved_in	GO:0061408	positive regulation of transcription from RNA polymerase II promoter in response to heat stress	PMID:12869585^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(WB:WBGene00001527) occurs_in:(WBbt:0005772)	Seeded From UniProt	complete
involved_in	GO:0048382	mesendoderm development	PMID:1547503^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12869585^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(WB:WBGene00001527) occurs_in:(WBbt:0005772)\|has_regulation_target(WB:WBGene00001527) occurs_in:(WBbt:0005666)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9628487^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:24068940^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20163	F		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	PMID:8861906^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00275483	P		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:12869585^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(WBbt:0005772)	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:20523893^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006414	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:18358814^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00275483 WB:WBVar00275491 WB:WBVar00275492	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:12869585^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	PMID:24068940^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:12869585^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(WBbt:0005772)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:24068940^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23040073^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12869585^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005772)\|part_of:(WBbt:0005733)\|part_of:(WBbt:0003888) part_of:(WBbt:0003887)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8348611^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001714	endodermal cell fate specification	PMID:15979606^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00001311	P		Seeded From UniProt	complete
involved_in	GO:0001714	endodermal cell fate specification	PMID:15979606^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00001310	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:8861906^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00275483	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:12869585^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(WB:WBGene00001527)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:24068940^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0030968) has_direct_input:(WB:WBGene00004804)	Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	PMID:12869585^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	PMID:12869585^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(WBbt:0005772)	Seeded From UniProt	complete
involved_in	GO:1900409	positive regulation of cellular response to oxidative stress	PMID:22560223^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:22560223^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:1547503^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:1547503^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR008917	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR004827 InterPro:IPR008917	P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Park, SK et al. (2010) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 24 383-92 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Vora, S & Phillips, BT (2015) Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division. Curr. Biol. 25 1005-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Inoue, H et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 2278-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Settivari, R et al. (2013) The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. Neurotoxicology 38 51-60 PubMed GONUTS page
↑ Mendes, TK et al. (2015) Investigating the role of RIO protein kinases in Caenorhabditis elegans. PLoS ONE 10 e0117444 PubMed GONUTS page
↑ Carroll, AS et al. (1997) SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev. 11 2227-38 PubMed GONUTS page
↑ Staab, TA et al. (2014) Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress. PLoS Genet. 10 e1004100 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 An, JH & Blackwell, TK (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 17 1882-93 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bowerman, B et al. (1992) skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68 1061-75 PubMed GONUTS page
↑ Rupert, PB et al. (1998) A new DNA-binding motif in the Skn-1 binding domain-DNA complex. Nat. Struct. Biol. 5 484-91 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Glover-Cutter, KM et al. (2013) Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 9 e1003701 PubMed GONUTS page
↑ ^12.0 ^12.1 Hunter, CP & Kenyon, C (1996) Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell 87 217-26 PubMed GONUTS page
↑ Schreiber, MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 6 e1000972 PubMed GONUTS page
↑ Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page
↑ Paek, J et al. (2012) Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 16 526-37 PubMed GONUTS page
↑ Bowerman, B et al. (1993) The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos. Cell 74 443-52 PubMed GONUTS page
↑ ^17.0 ^17.1 Maduro, MF et al. (2005) Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev. Biol. 284 509-22 PubMed GONUTS page
↑ ^18.0 ^18.1 Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15 713-24 PubMed GONUTS page

[PMID:19783783-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Park, SK et al. (2010) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 24 383-92 PubMed GONUTS page

[PMID:25819561-2] 2.0 ^2.1 ^2.2 ^2.3 Vora, S & Phillips, BT (2015) Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division. Curr. Biol. 25 1005-16 PubMed GONUTS page

[PMID:16166371-3] 3.0 ^3.1 Inoue, H et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 2278-83 PubMed GONUTS page

[PMID:23721876-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Settivari, R et al. (2013) The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. Neurotoxicology 38 51-60 PubMed GONUTS page

[PMID:25688864-5] Mendes, TK et al. (2015) Investigating the role of RIO protein kinases in Caenorhabditis elegans. PLoS ONE 10 e0117444 PubMed GONUTS page

[PMID:9303538-6] Carroll, AS et al. (1997) SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev. 11 2227-38 PubMed GONUTS page

[PMID:24453991-7] Staab, TA et al. (2014) Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress. PLoS Genet. 10 e1004100 PubMed GONUTS page

[PMID:12869585-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 An, JH & Blackwell, TK (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 17 1882-93 PubMed GONUTS page

[PMID:1547503-9] 9.0 ^9.1 ^9.2 Bowerman, B et al. (1992) skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68 1061-75 PubMed GONUTS page

[PMID:9628487-10] Rupert, PB et al. (1998) A new DNA-binding motif in the Skn-1 binding domain-DNA complex. Nat. Struct. Biol. 5 484-91 PubMed GONUTS page

[PMID:24068940-11] 11.0 ^11.1 ^11.2 ^11.3 Glover-Cutter, KM et al. (2013) Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 9 e1003701 PubMed GONUTS page

[PMID:8861906-12] 12.0 ^12.1 Hunter, CP & Kenyon, C (1996) Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell 87 217-26 PubMed GONUTS page

[PMID:20523893-13] Schreiber, MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 6 e1000972 PubMed GONUTS page

[PMID:18358814-14] Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page

[PMID:23040073-15] Paek, J et al. (2012) Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 16 526-37 PubMed GONUTS page

[PMID:8348611-16] Bowerman, B et al. (1993) The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos. Cell 74 443-52 PubMed GONUTS page

[PMID:15979606-17] 17.0 ^17.1 Maduro, MF et al. (2005) Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev. Biol. 284 509-22 PubMed GONUTS page

[PMID:22560223-18] 18.0 ^18.1 Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15 713-24 PubMed GONUTS page

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CAEEL:SKN1

Contents

Annotations

Notes

References

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