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CAEEL:SKN1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) skn-1
Protein Name(s) Protein skinhead-1
External Links
UniProt P34707
EMBL FO080233
FO080233
FO080233
M84359
PIR A42143
F88694
RefSeq NP_741404.1
NP_741405.1
NP_741406.1
UniGene Cel.23037
PDB 1SKN
PDBsum 1SKN
ProteinModelPortal P34707
SMR P34707
BioGrid 42465
IntAct P34707
MINT MINT-1094083
BindingDB P34707
ChEMBL CHEMBL2146298
PaxDb P34707
PRIDE P34707
EnsemblMetazoa T19E7.2a
GeneID 177343
KEGG cel:CELE_T19E7.2
UCSC T19E7.2b
CTD 177343
WormBase T19E7.2a
T19E7.2b
T19E7.2c
eggNOG NOG309753
GeneTree ENSGT00510000052725
HOGENOM HOG000021747
InParanoid P34707
OMA GLRWRDD
SignaLink P34707
EvolutionaryTrace P34707
NextBio 896360
Proteomes UP000001940
GO GO:0005783
GO:0005739
GO:0005634
GO:0030544
GO:0000977
GO:0043565
GO:0003700
GO:0001708
GO:0008340
GO:0009880
GO:0001714
GO:0048382
GO:0007275
GO:1900409
GO:0045944
GO:0061408
GO:0006990
GO:0009408
GO:0006979
GO:0000303
GO:0006351
Gene3D 1.10.880.10
InterPro IPR004827
IPR004826
IPR008917
Pfam PF03131
SUPFAM SSF47454
PROSITE PS00036

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000303

response to superoxide

PMID:12869585[1]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0000303

response to superoxide

PMID:12869585[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:12869585[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:24068940[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:24453991[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001708

cell fate specification

PMID:8861906[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00275483

P

Seeded From UniProt

complete

GO:0001714

endodermal cell fate specification

PMID:15979606[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00001310

P

Seeded From UniProt

complete

GO:0001714

endodermal cell fate specification

PMID:15979606[5]

IGI: Inferred from Genetic Interaction

WB:WBGene00001311

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004826
InterPro:IPR008917

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004827

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:1547503[6]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19273594[7]

IPI: Inferred from Physical Interaction

UniProtKB:P90794

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19273594[7]

IPI: Inferred from Physical Interaction

WB:WBGene00008419

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004826

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12869585[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16166371[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:8348611[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:23040073[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

PMID:24068940[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004826
InterPro:IPR004827
InterPro:IPR008917

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:12869585[1]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0006990

positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

PMID:24068940[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16166371[8]

IDA: Inferred from Direct Assay

C

figure 2

complete
CACAO 6993

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

PMID:1547503[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:12869585[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:18358814[11]

IMP: Inferred from Mutant Phenotype

WB:WBVar00275483
WB:WBVar00275491
WB:WBVar00275492

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:20523893[12]

IGI: Inferred from Genetic Interaction

WB:WBGene00006414

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:22560223[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009408

response to heat

PMID:12869585[1]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0009880

embryonic pattern specification

PMID:8861906[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00275483

P

Seeded From UniProt

complete

GO:0030544

Hsp70 protein binding

PMID:24068940[2]

IPI: Inferred from Physical Interaction

UniProtKB:P20163

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004827

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:9303538[14]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:9628487[15]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:12869585[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:25688864[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048382

mesendoderm development

PMID:1547503[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0061408

positive regulation of transcription from RNA polymerase II promoter in response to heat stress

PMID:12869585[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900409

positive regulation of cellular response to oxidative stress

PMID:22560223[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 An, JH & Blackwell, TK (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 17 1882-93 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Glover-Cutter, KM et al. (2013) Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 9 e1003701 PubMed GONUTS page
  3. Staab, TA et al. (2014) Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress. PLoS Genet. 10 e1004100 PubMed GONUTS page
  4. 4.0 4.1 Hunter, CP & Kenyon, C (1996) Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell 87 217-26 PubMed GONUTS page
  5. 5.0 5.1 Maduro, MF et al. (2005) Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev. Biol. 284 509-22 PubMed GONUTS page
  6. 6.0 6.1 6.2 Bowerman, B et al. (1992) skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68 1061-75 PubMed GONUTS page
  7. 7.0 7.1 Choe, KP et al. (2009) The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol. Cell. Biol. 29 2704-15 PubMed GONUTS page
  8. 8.0 8.1 Inoue, H et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 2278-83 PubMed GONUTS page
  9. Bowerman, B et al. (1993) The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos. Cell 74 443-52 PubMed GONUTS page
  10. Paek, J et al. (2012) Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 16 526-37 PubMed GONUTS page
  11. Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page
  12. Schreiber, MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 6 e1000972 PubMed GONUTS page
  13. 13.0 13.1 Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15 713-24 PubMed GONUTS page
  14. Carroll, AS et al. (1997) SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev. 11 2227-38 PubMed GONUTS page
  15. Rupert, PB et al. (1998) A new DNA-binding motif in the Skn-1 binding domain-DNA complex. Nat. Struct. Biol. 5 484-91 PubMed GONUTS page
  16. Mendes, TK et al. (2015) Investigating the role of RIO protein kinases in Caenorhabditis elegans. PLoS ONE 10 e0117444 PubMed GONUTS page