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PMID:1547503
| Citation |
Bowerman, B, Eaton, BA and Priess, JR (1992) skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68:1061-75 |
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| Abstract |
By the 4-cell stage of C. elegans embryogenesis, a ventral blastomere, called EMS, is already committed to producing pharyngeal and intestinal cell types. Recessive, maternal-effect mutations in the gene skn-1 prevent EMS from producing both pharyngeal and intestinal cells. In skn-1 mutant embryos, EMS instead produces hypodermal cells and body wall muscle cells, much like its sister blastomere. Genetic analysis suggests that the skn-1 gene product is also required post-embryonically for development of the intestine. We have cloned and sequenced the skn-1 gene and describe sequence similarities to the basic regions of bZIP transcription factors. We propose that the maternally expressed skn-1 gene product acts to specify the fate of the EMS blastomere. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Blastomeres/cytology; Caenorhabditis/embryology; Caenorhabditis/genetics; Caenorhabditis elegans Proteins; Cloning, Molecular; DNA-Binding Proteins; Gene Expression/genetics; Helminth Proteins/genetics; Intestines/embryology; Molecular Sequence Data; Pharynx/embryology; Sequence Alignment; Transcription Factors/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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