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CAEEL:CNG

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) tax-4
Protein Name(s) Cyclic nucleotide-gated cation channel

Abnormal chemotaxis protein 4

External Links
UniProt Q03611
EMBL D86922
Z19157
PIR S28292
RefSeq NP_499033.1
UniGene Cel.19693
ProteinModelPortal Q03611
SMR Q03611
TCDB 1.A.1.5.20
EnsemblMetazoa ZC84.2
GeneID 176297
KEGG cel:CELE_ZC84.2
UCSC ZC84.2
CTD 176297
WormBase ZC84.2
eggNOG NOG300025
GeneTree ENSGT00760000118772
HOGENOM HOG000007898
InParanoid Q03611
KO K05326
OMA WNALREY
OrthoDB EOG771268
PhylomeDB Q03611
Reactome REACT_184868
REACT_197698
NextBio 891976
Proteomes UP000001940
GO GO:0030425
GO:0016021
GO:0005887
GO:0031513
GO:0030553
GO:0005222
GO:0005223
GO:0005249
GO:0009454
GO:0007635
GO:0048812
GO:0042048
GO:0007603
GO:0045944
GO:0071805
GO:0030516
GO:0042391
GO:0045664
GO:0055093
GO:0070482
GO:0040040
GO:0043052
Gene3D 2.60.120.10
InterPro IPR018490
IPR018488
IPR000595
IPR005821
IPR003938
IPR014710
Pfam PF00027
PF00520
PRINTS PR01463
SMART SM00100
SUPFAM SSF51206
PROSITE PS00888
PS00889
PS50042

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006935

chemotaxis

PMID:21435556[1]

IMP: Inferred from Mutant Phenotype

P

Mutation to cGMP-gated channel unit tax-4 causes significant decrease in avoidance of CO2 behavior (Fig. 1C)

complete
CACAO 7229

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0005216

ion channel activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

F

Seeded From UniProt

complete

GO:0005222

intracellular cAMP activated cation channel activity

PMID:8893027[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005223

intracellular cGMP activated cation channel activity

PMID:10064800[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005223

intracellular cGMP activated cation channel activity

PMID:8893027[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005249

voltage-gated potassium channel activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003938

F

Seeded From UniProt

complete

GO:0005249

voltage-gated potassium channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000025348

F

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000025348

C

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

GO:0006813

potassium ion transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003938

P

Seeded From UniProt

complete

GO:0006935

chemotaxis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0145

P

Seeded From UniProt

complete

GO:0006935

chemotaxis

PMID:21435556[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

GO:0007635

chemosensory behavior

PMID:8893027[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009454

aerotaxis

PMID:15220933[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088281

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003938
InterPro:IPR005821

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:8893027[2]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0030425

dendrite

PMID:8893027[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030516

regulation of axon extension

PMID:9486798[5]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088404
WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0030553

cGMP binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000025935

F

Seeded From UniProt

complete

GO:0030553

cGMP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0142

F

Seeded From UniProt

complete

GO:0030553

cGMP binding

PMID:8893027[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0031513

nonmotile primary cilium

PMID:23886944[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031513

nonmotile primary cilium

PMID:25335890[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031513

nonmotile primary cilium

PMID:8893027[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0040010

positive regulation of growth rate

PMID:15530424[8]

IGI: Inferred from Genetic Interaction

WB:WBGene00000563

P

Seeded From UniProt

complete

GO:0040040

thermosensory behavior

PMID:11879652[9]

IGI: Inferred from Genetic Interaction

WB:WBGene00006527

P

Seeded From UniProt

complete

GO:0040040

thermosensory behavior

PMID:11879652[9]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0040040

thermosensory behavior

PMID:14711416[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0040040

thermosensory behavior

PMID:8893027[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042048

olfactory behavior

PMID:11879652[9]

IGI: Inferred from Genetic Interaction

WB:WBGene00006527

P

Seeded From UniProt

complete

GO:0042048

olfactory behavior

PMID:11879652[9]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0042391

regulation of membrane potential

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000025348

P

Seeded From UniProt

complete

GO:0043052

thermotaxis

PMID:11879652[9]

IGI: Inferred from Genetic Interaction

WB:WBGene00006527

P

Seeded From UniProt

complete

GO:0043052

thermotaxis

PMID:11879652[9]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0045664

regulation of neuron differentiation

PMID:14711416[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095030
WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:14711416[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095030
WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0048609

multicellular organismal reproductive process

PMID:15530424[8]

IGI: Inferred from Genetic Interaction

WB:WBGene00000563

P

Seeded From UniProt

complete

GO:0048812

neuron projection morphogenesis

PMID:14711416[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00095116

P

Seeded From UniProt

complete

GO:0055085

transmembrane transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

P

Seeded From UniProt

complete

GO:0055093

response to hyperoxia

PMID:15220933[4]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088281

P

Seeded From UniProt

complete

GO:0070482

response to oxygen levels

PMID:19323996[11]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088281

P

Seeded From UniProt

complete

GO:0071805

potassium ion transmembrane transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000025348

P

Seeded From UniProt

complete

GO:0097543

ciliary inversin compartment

PMID:25335890[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0098655

cation transmembrane transport

PMID:10064800[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bretscher, AJ et al. (2011) Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron 69 1099-113 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Komatsu, H et al. (1996) Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17 707-18 PubMed GONUTS page
  3. 3.0 3.1 Komatsu, H et al. (1999) Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res. 821 160-8 PubMed GONUTS page
  4. 4.0 4.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page
  5. Coburn, CM et al. (1998) A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125 249-58 PubMed GONUTS page
  6. Wojtyniak, M et al. (2013) Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. J. Cell. Sci. 126 4381-95 PubMed GONUTS page
  7. 7.0 7.1 Nguyen, PA et al. (2014) Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J. Cell. Sci. 127 5317-30 PubMed GONUTS page
  8. 8.0 8.1 Cho, SW et al. (2004) A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 325 525-31 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Kuhara, A et al. (2002) Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6. Neuron 33 751-63 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Satterlee, JS et al. (2004) The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr. Biol. 14 62-8 PubMed GONUTS page
  11. Zimmer, M et al. (2009) Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron 61 865-79 PubMed GONUTS page