CAEEL:CNG

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	tax-4
Protein Name(s)	Cyclic nucleotide-gated cation channel Abnormal chemotaxis protein 4
External Links
UniProt	Q03611
EMBL	D86922 Z19157
PIR	S28292
RefSeq	NP_499033.1
UniGene	Cel.19693
ProteinModelPortal	Q03611
SMR	Q03611
TCDB	1.A.1.5.20
EnsemblMetazoa	ZC84.2
GeneID	176297
KEGG	cel:CELE_ZC84.2
UCSC	ZC84.2
CTD	176297
WormBase	ZC84.2
eggNOG	NOG300025
GeneTree	ENSGT00760000118772
HOGENOM	HOG000007898
InParanoid	Q03611
KO	K05326
OMA	WNALREY
OrthoDB	EOG771268
PhylomeDB	Q03611
Reactome	REACT_184868 REACT_197698
NextBio	891976
Proteomes	UP000001940
GO	GO:0030425 GO:0016021 GO:0005887 GO:0031513 GO:0030553 GO:0005222 GO:0005223 GO:0005249 GO:0009454 GO:0007635 GO:0048812 GO:0042048 GO:0007603 GO:0045944 GO:0071805 GO:0030516 GO:0042391 GO:0045664 GO:0055093 GO:0070482 GO:0040040 GO:0043052
Gene3D	2.60.120.10
InterPro	IPR018490 IPR018488 IPR000595 IPR005821 IPR003938 IPR014710
Pfam	PF00027 PF00520
PRINTS	PR01463
SMART	SM00100
SUPFAM	SSF51206
PROSITE	PS00888 PS00889 PS50042

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006935	chemotaxis	PMID:21435556^[1]	ECO:0000315			P		Mutation to cGMP-gated channel unit tax-4 causes significant decrease in avoidance of CO2 behavior (Fig. 1C)	complete CACAO 7229
part_of	GO:0034703	cation channel complex	PMID:10064800^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010754	negative regulation of cGMP-mediated signaling	PMID:23940325^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0004096)	Seeded From UniProt	complete
involved_in	GO:0070482	response to oxygen levels	PMID:23940325^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0004096)	Seeded From UniProt	complete
involved_in	GO:0007602	phototransduction	PMID:20436480^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:21315599^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0040040) occurs_in:(WBbt:0005662)	Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:21315599^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005662)	Seeded From UniProt	complete
involved_in	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	PMID:20436480^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005667)	Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:25335890^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005662)	Seeded From UniProt	complete
enables	GO:0005223	intracellular cGMP-activated cation channel activity	PMID:10064800^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	PMID:10064800^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040010	positive regulation of growth rate	PMID:15530424^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000563	P		Seeded From UniProt	complete
involved_in	GO:0048609	multicellular organismal reproductive process	PMID:15530424^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000563	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:24240097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0003031) occurs_in:(WBbt:0006825) part_of:(GO:0050907)	Seeded From UniProt	complete
involved_in	GO:0003031	detection of carbon dioxide	PMID:24240097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0050907) occurs_in:(WBbt:0006825) causally_upstream_of:(GO:0019722) part_of:(GO:1904457)	Seeded From UniProt	complete
involved_in	GO:0050907	detection of chemical stimulus involved in sensory perception	PMID:24240097^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0003031) occurs_in:(WBbt:0006825) causally_upstream_of:(GO:0019722) part_of:(GO:1904457)	Seeded From UniProt	complete
part_of	GO:0097543	ciliary inversin compartment	PMID:25335890^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005394)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:25303524^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P92172) occurs_in:(WBbt:0005666) occurs_in:(WBbt:0005667)	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21435556^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070482	response to oxygen levels	PMID:19323996^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088281	P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	PMID:15220933^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088281	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:14711416^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095116	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14711416^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095030 WB:WBVar00095116	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	PMID:14711416^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095030 WB:WBVar00095116	P		Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:11879652^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006527	P		Seeded From UniProt	complete
involved_in	GO:0043052	thermotaxis	PMID:11879652^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095116	P		Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:11879652^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006527	P		Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:11879652^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095116	P		Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:11879652^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006527	P		Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:14711416^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095116	P		Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:11879652^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00095116	P		Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:8893027^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:23886944^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030516	regulation of axon extension	PMID:9486798^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088404 WB:WBVar00095116	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:8893027^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009454	aerotaxis	PMID:15220933^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088281	P		Seeded From UniProt	complete
enables	GO:0005223	intracellular cGMP-activated cation channel activity	PMID:8893027^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005222	intracellular cAMP-activated cation channel activity	PMID:8893027^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0040040	thermosensory behavior	PMID:8893027^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030553	cGMP binding	PMID:8893027^[14]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:8893027^[14]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007635	chemosensory behavior	PMID:8893027^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030553	cGMP binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000025806 RGD:2367 RGD:619844 RGD:621815 RGD:70948 UniProtKB:Q00194 UniProtKB:Q16281	F		Seeded From UniProt	complete
enables	GO:0005223	intracellular cGMP-activated cation channel activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000025806 RGD:2367 RGD:619844 RGD:621815 RGD:70948 UniProtKB:Q00194 UniProtKB:Q16281 WB:WBGene00006526	F		Seeded From UniProt	complete
enables	GO:0005222	intracellular cAMP-activated cation channel activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000025806 RGD:2367 RGD:619844 WB:WBGene00006526	F		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005249	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938 InterPro:IPR005821	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0030553	cGMP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0142	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bretscher, AJ et al. (2011) Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron 69 1099-113 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Komatsu, H et al. (1999) Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res. 821 160-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Couto, A et al. (2013) In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc. Natl. Acad. Sci. U.S.A. 110 E3301-10 PubMed GONUTS page
↑ ^4.0 ^4.1 Liu, J et al. (2010) C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13 715-22 PubMed GONUTS page
↑ ^5.0 ^5.1 Wasserman, SM et al. (2011) Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling. Curr. Biol. 21 353-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Nguyen, PA et al. (2014) Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J. Cell. Sci. 127 5317-30 PubMed GONUTS page
↑ ^7.0 ^7.1 Cho, SW et al. (2004) A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 325 525-31 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Smith, ES et al. (2013) A chemoreceptor that detects molecular carbon dioxide. J. Biol. Chem. 288 37071-81 PubMed GONUTS page
↑ Meisel, JD et al. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell 159 267-80 PubMed GONUTS page
↑ Zimmer, M et al. (2009) Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron 61 865-79 PubMed GONUTS page
↑ ^11.0 ^11.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Satterlee, JS et al. (2004) The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr. Biol. 14 62-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Kuhara, A et al. (2002) Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6. Neuron 33 751-63 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Komatsu, H et al. (1996) Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17 707-18 PubMed GONUTS page
↑ Wojtyniak, M et al. (2013) Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. J. Cell. Sci. 126 4381-95 PubMed GONUTS page
↑ Coburn, CM et al. (1998) A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125 249-58 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21435556-1] 1.0 ^1.1 Bretscher, AJ et al. (2011) Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron 69 1099-113 PubMed GONUTS page

[PMID:10064800-2] 2.0 ^2.1 ^2.2 Komatsu, H et al. (1999) Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res. 821 160-8 PubMed GONUTS page

[PMID:23940325-3] 3.0 ^3.1 Couto, A et al. (2013) In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc. Natl. Acad. Sci. U.S.A. 110 E3301-10 PubMed GONUTS page

[PMID:20436480-4] 4.0 ^4.1 Liu, J et al. (2010) C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13 715-22 PubMed GONUTS page

[PMID:21315599-5] 5.0 ^5.1 Wasserman, SM et al. (2011) Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling. Curr. Biol. 21 353-62 PubMed GONUTS page

[PMID:25335890-6] 6.0 ^6.1 Nguyen, PA et al. (2014) Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J. Cell. Sci. 127 5317-30 PubMed GONUTS page

[PMID:15530424-7] 7.0 ^7.1 Cho, SW et al. (2004) A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 325 525-31 PubMed GONUTS page

[PMID:24240097-8] 8.0 ^8.1 ^8.2 Smith, ES et al. (2013) A chemoreceptor that detects molecular carbon dioxide. J. Biol. Chem. 288 37071-81 PubMed GONUTS page

[PMID:25303524-9] Meisel, JD et al. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell 159 267-80 PubMed GONUTS page

[PMID:19323996-10] Zimmer, M et al. (2009) Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron 61 865-79 PubMed GONUTS page

[PMID:15220933-11] 11.0 ^11.1 Gray, JM et al. (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 317-22 PubMed GONUTS page

[PMID:14711416-12] 12.0 ^12.1 ^12.2 ^12.3 Satterlee, JS et al. (2004) The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr. Biol. 14 62-8 PubMed GONUTS page

[PMID:11879652-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Kuhara, A et al. (2002) Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6. Neuron 33 751-63 PubMed GONUTS page

[PMID:8893027-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Komatsu, H et al. (1996) Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17 707-18 PubMed GONUTS page

[PMID:23886944-15] Wojtyniak, M et al. (2013) Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. J. Cell. Sci. 126 4381-95 PubMed GONUTS page

[PMID:9486798-16] Coburn, CM et al. (1998) A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125 249-58 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:CNG

Contents

Annotations

Notes

References

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