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PMID:11879652
| Citation |
Kuhara, A, Inada, H, Katsura, I and Mori, I (2002) Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6. Neuron 33:751-63 |
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| Abstract |
Animals sense and adapt to variable environments by regulating appropriate sensory signal transduction pathways. Here, we show that calcineurin plays a key role in regulating the gain of sensory neuron responsiveness across multiple modalities. C. elegans animals bearing a loss-of-function mutation in TAX-6, a calcineurin A subunit, exhibit pleiotropic abnormalities, including many aberrant sensory behaviors. The tax-6 mutant defect in thermosensation is consistent with hyperactivation of the AFD thermosensory neurons. Conversely, constitutive activation of TAX-6 causes a behavioral phenotype consistent with inactivation of AFD neurons. In olfactory neurons, the impaired olfactory response of tax-6 mutants to an AWC-sensed odorant is caused by hyperadaptation, which is suppressible by a mutation causing defective olfactory adaptation. Taken together, our results suggest that stimulus-evoked calcium entry activates calcineurin, which in turn negatively regulates multiple aspects of sensory signaling. |
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| Keywords |
Amino Acid Sequence; Animals; Animals, Genetically Modified; Caenorhabditis elegans/cytology; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Calcineurin/chemistry; Calcineurin/genetics; Calcineurin/metabolism; Humans; Ion Channels/genetics; Ion Channels/metabolism; Locomotion; Models, Biological; Molecular Sequence Data; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurons, Afferent/physiology; Osmolar Concentration; Pentanols/metabolism; Phenotype; Protein Subunits; Recombinant Fusion Proteins/metabolism; Sequence Alignment; Signal Transduction; Smell/physiology; Thermosensing; Transient Receptor Potential Channels |
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Significance
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