BOVIN:TRFL

Species (Taxon ID)	Bos taurus (Bovine). (9913)
Gene Name(s)	LTF
Protein Name(s)	Lactotransferrin Lactoferrin Lactoferricin-B Lfcin-B
External Links
UniProt	P24627
EMBL	X57084 M63502 L08604 L19993 L19982 L19983 L19984 L19985 L19986 L19988 L19989 L19990 L19991 L19992 L19981 AB046664 BC116051
PIR	I45919
RefSeq	NP_851341.1 XP_005223077.1
UniGene	Bt.44264
PDB	1BLF 1LFC 1NKX 1SDX 1Y58 2ALU 2AYS 2B65 2DOJ 2DP8 2DQV 2DS9 2DSF 2DVC 2DWA 2DWH 2DWI 2DWJ 2DXR 2DXY 2DYX 2E0S 2E1S 2FA7 2G93 2H4I 2HCA 2MD1 2MD2 2MD3 2MD4 2NUV 2NWJ 2O1L 2O51 2OCU 2P1S 2PX1 2Q8J 2QJE 2R71 2R9J 2ZMB 3CFL 3CI8 3CRB 3E9X 3IAZ 3IB0 3IB1 3IB2 3K0V 3KJ7 3MJN 3O97 3RGY 3SDF 3TAJ 3TOD 3TTR 3TUS 3U72 3U8Q 3UGW 3UK4 3USD 3V5A 3VDF 4DIG 4DXU 4FIM 4FJP 4FOR 4G2Z 4G77 4G8H 4GRK 4N6P 4NED 4OQO
PDBsum	1BLF 1LFC 1NKX 1SDX 1Y58 2ALU 2AYS 2B65 2DOJ 2DP8 2DQV 2DS9 2DSF 2DVC 2DWA 2DWH 2DWI 2DWJ 2DXR 2DXY 2DYX 2E0S 2E1S 2FA7 2G93 2H4I 2HCA 2MD1 2MD2 2MD3 2MD4 2NUV 2NWJ 2O1L 2O51 2OCU 2P1S 2PX1 2Q8J 2QJE 2R71 2R9J 2ZMB 3CFL 3CI8 3CRB 3E9X 3IAZ 3IB0 3IB1 3IB2 3K0V 3KJ7 3MJN 3O97 3RGY 3SDF 3TAJ 3TOD 3TTR 3TUS 3U72 3U8Q 3UGW 3UK4 3USD 3V5A 3VDF 4DIG 4DXU 4FIM 4FJP 4FOR 4G2Z 4G77 4G8H 4GRK 4N6P 4NED 4OQO
ProteinModelPortal	P24627
SMR	P24627
BioGrid	158240
IntAct	P24627
ChEMBL	CHEMBL2796
Allergome	1065
MEROPS	S60.970
UniCarbKB	P24627
PaxDb	P24627
PRIDE	P24627
Ensembl	ENSBTAT00000001704
GeneID	280846
KEGG	bta:280846
CTD	4057
eggNOG	NOG87503
GeneTree	ENSGT00390000001619
HOGENOM	HOG000043759
HOVERGEN	HBG000055
InParanoid	P24627
KO	K17283
OMA	NKCACSS
OrthoDB	EOG7D59N7
TreeFam	TF324013
Reactome	REACT_206540 REACT_220738 REACT_268934
EvolutionaryTrace	P24627
NextBio	20804994
PMAP-CutDB	P24627
Proteomes	UP000009136
ExpressionAtlas	P24627
GO	GO:0005615 GO:0070062 GO:0005634 GO:0042581 GO:0008199 GO:0008201 GO:0043539 GO:0005102 GO:0008236 GO:0019731 GO:0019732 GO:0060349 GO:0006879 GO:0002227 GO:0006826 GO:0043066 GO:0031665 GO:2001205 GO:1900229 GO:2000308 GO:0001503 GO:1900159 GO:1902732 GO:0043123 GO:0051092 GO:0045669 GO:0033690 GO:0034145 GO:0001817 GO:0032680 GO:0001895
InterPro	IPR016357 IPR001156 IPR018195
Pfam	PF00405
PIRSF	PIRSF002549
PRINTS	PR00422
SMART	SM00094
PROSITE	PS00205 PS00206 PS00207 PS51408

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009650	UV protection	PMID:24424315^[1]	ECO:0000314			P		Figure 1: Electrophoresis shows Lactoferrin protects DNA exposed to the Fenton reaction in a dose-dependent manner.	complete CACAO 9461
part_of	GO:0005615	extracellular space	PMID:12788072^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	PMID:12788072^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000117	negative regulation of cysteine-type endopeptidase activity	PMID:12788072^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:15226301^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001205	negative regulation of osteoclast development	PMID:15166119^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000308	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production	PMID:15166119^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002092) occurs_in:(CL:0000062)	Seeded From UniProt	complete
involved_in	GO:1902732	positive regulation of chondrocyte proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:1900159	positive regulation of bone mineralization involved in bone maturation	PMID:15166119^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15166119^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000062)	Seeded From UniProt	complete
part_of	GO:0042581	specific granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	C	part_of:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	PMID:15166119^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032680	regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:1599934^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02788	P		Seeded From UniProt	complete
involved_in	GO:2000117	negative regulation of cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:1902732	positive regulation of chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0048525	negative regulation of viral process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0044793	negative regulation by host of viral process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
part_of	GO:0044218	other organism cell membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
part_of	GO:0042581	specific granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0032680	regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	C		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	F		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	F		Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02788 ensembl:ENSP00000231751	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08071 ensembl:ENSMUSP00000035077	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08071 ensembl:ENSMUSP00000035077	C		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018195 InterPro:IPR030684	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016357	C		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	P		Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ogasawara, Y et al. (2014) Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage. Int J Mol Sci 15 1003-13 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ohashi, A et al. (2003) New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Biochem. Biophys. Res. Commun. 306 98-103 PubMed GONUTS page
↑ Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cornish, J et al. (2004) Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145 4366-74 PubMed GONUTS page
↑ Bellamy, W et al. (1992) Identification of the bactericidal domain of lactoferrin. Biochim. Biophys. Acta 1121 130-6 PubMed GONUTS page

[PMID:24424315-1] Ogasawara, Y et al. (2014) Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage. Int J Mol Sci 15 1003-13 PubMed GONUTS page

[PMID:12788072-2] 2.0 ^2.1 ^2.2 Ohashi, A et al. (2003) New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Biochem. Biophys. Res. Commun. 306 98-103 PubMed GONUTS page

[PMID:15226301-3] Ling, TY et al. (2004) Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J. Biol. Chem. 279 38736-48 PubMed GONUTS page

[PMID:15166119-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cornish, J et al. (2004) Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145 4366-74 PubMed GONUTS page

[PMID:1599934-5] Bellamy, W et al. (1992) Identification of the bactericidal domain of lactoferrin. Biochim. Biophys. Acta 1121 130-6 PubMed GONUTS page

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BOVIN:TRFL

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