BACSU:FUR

Species (Taxon ID)	Bacillus subtilis (strain 168). (224308)
Gene Name(s)	fur (synonyms: yqkL)
Protein Name(s)	Ferric uptake regulation protein Ferric uptake regulator
External Links
UniProt	P54574
EMBL	D84432 AL009126
PIR	E69967
RefSeq	NP_390233.2
ProteinModelPortal	P54574
SMR	P54574
STRING	224308.BSU23520
PaxDb	P54574
EnsemblBacteria	CAB14284
GeneID	938727
KEGG	bsu:BSU23520
PATRIC	18976525
GenoList	BSU23520
eggNOG	COG0735
HOGENOM	HOG000014143
InParanoid	P54574
KO	K03711
OMA	DERSDIG
OrthoDB	EOG6J48SS
PhylomeDB	P54574
BioCyc	BSUB:BSU23520-MONOMER
Proteomes	UP000001570
GO	GO:0005737 GO:0003677 GO:0046872 GO:0003700 GO:0045892 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR002481 IPR011991
Pfam	PF01475

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9701813^[1]	ECO:0000315			P	As the iron-dependent repression of both catechol siderophore synthesis (Fig. 2) and hydroxamate siderophore uptake genes (Fig. 3A) is dependent on yqkL, we conclude that yqkL encodes a ferric uptake repressor protein, Fur. B. subtilis Fur recognizes operator sites similar to the consensus established for E. coli Fur.	complete CACAO 2741
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9701813^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873409^[2]	ECO:0005661	rapid amplification of cDNA ends polymerase chain reaction evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16672620^[3]	ECO:0005614	two-dimensional polyacrylamide gel electrophoresis evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10400588^[4]	ECO:0001204	in vitro transcription assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12374814^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:14563870^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12354229^[7]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:21873409^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:16672620^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12374814^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12354229^[7]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:10400588^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:14563870^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12354229^[7]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:21873409^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:16672620^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12354229^[7]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:10400588^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:14563870^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12354229^[7]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873409^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16672620^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12354229^[7]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:10400588^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1900376	regulation of secondary metabolite biosynthetic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q9HT74	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112386 UniProtKB:P0A0S8 UniProtKB:P0C6C8 UniProtKB:P54479 UniProtKB:P54574 UniProtKB:P74739 UniProtKB:P9WN85 UniProtKB:Q03456 UniProtKB:Q7BR72 UniProtKB:Q7CQY3 UniProtKB:Q8EFN3 UniProtKB:Q8PAL3 UniProtKB:Q8Y5U9 UniProtKB:Q9HT74 UniProtKB:Q9L2H5	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q03456	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112386 UniProtKB:P9WN85	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:P9WN87	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q9HT74	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002481	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002481	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bsat, N et al. (1998) Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors. Mol. Microbiol. 29 189-98 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaballa, A & Helmann, JD (2011) Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases. Microbiology (Reading, Engl.) 157 3221-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Ollinger, J et al. (2006) Role of the Fur regulon in iron transport in Bacillus subtilis. J. Bacteriol. 188 3664-73 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Bsat, N & Helmann, JD (1999) Interaction of Bacillus subtilis Fur (ferric uptake repressor) with the dhb operator in vitro and in vivo. J. Bacteriol. 181 4299-307 PubMed GONUTS page
↑ ^5.0 ^5.1 Baichoo, N & Helmann, JD (2002) Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence. J. Bacteriol. 184 5826-32 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Fuangthong, M & Helmann, JD (2003) Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis. J. Bacteriol. 185 6348-57 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Baichoo, N et al. (2002) Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol. Microbiol. 45 1613-29 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9701813-1] 1.0 ^1.1 Bsat, N et al. (1998) Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors. Mol. Microbiol. 29 189-98 PubMed GONUTS page

[PMID:21873409-2] 2.0 ^2.1 ^2.2 ^2.3 Gaballa, A & Helmann, JD (2011) Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases. Microbiology (Reading, Engl.) 157 3221-31 PubMed GONUTS page

[PMID:16672620-3] 3.0 ^3.1 ^3.2 ^3.3 Ollinger, J et al. (2006) Role of the Fur regulon in iron transport in Bacillus subtilis. J. Bacteriol. 188 3664-73 PubMed GONUTS page

[PMID:10400588-4] 4.0 ^4.1 ^4.2 ^4.3 Bsat, N & Helmann, JD (1999) Interaction of Bacillus subtilis Fur (ferric uptake repressor) with the dhb operator in vitro and in vivo. J. Bacteriol. 181 4299-307 PubMed GONUTS page

[PMID:12374814-5] 5.0 ^5.1 Baichoo, N & Helmann, JD (2002) Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence. J. Bacteriol. 184 5826-32 PubMed GONUTS page

[PMID:14563870-6] 6.0 ^6.1 ^6.2 Fuangthong, M & Helmann, JD (2003) Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis. J. Bacteriol. 185 6348-57 PubMed GONUTS page

[PMID:12354229-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Baichoo, N et al. (2002) Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol. Microbiol. 45 1613-29 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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BACSU:FUR

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