ARATH:RDR2

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	RDR2 (synonyms: RDRP2, SMD1)
Protein Name(s)	RNA-dependent RNA polymerase 2 AtRDRP2 Protein SILENCING MOVEMENT DEFICIENT 1 RNA-directed RNA polymerase 2
External Links
UniProt	O82504
EMBL	AF080120 AL049876 AL161531 CP002687
PIR	T01920
RefSeq	NP_192851.1
UniGene	At.43417
ProteinModelPortal	O82504
SMR	O82504
BioGrid	12013
STRING	3702.AT4G11130.1-P
PaxDb	O82504
PRIDE	O82504
EnsemblPlants	AT4G11130.1
GeneID	826714
KEGG	ath:AT4G11130
TAIR	AT4G11130
eggNOG	NOG252917
HOGENOM	HOG000239464
InParanoid	O82504
KO	K11699
OMA	GNSVWMF
PhylomeDB	O82504
BioCyc	ARA:AT4G11130-MONOMER
Proteomes	UP000006548
Genevestigator	O82504
GO	GO:0005730 GO:0005654 GO:0003723 GO:0003968 GO:0007267 GO:0050832 GO:0016458 GO:0010495 GO:0030422 GO:0016246
InterPro	IPR007855
PANTHER	PTHR23079
Pfam	PF05183

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070919	production of siRNA involved in chromatin silencing by small RNA	PMID:15024409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:22242006^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:15024409^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	PMID:15692015^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010495	long-distance posttranscriptional gene silencing	PMID:17785412^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0070919	production of siRNA involved in chromatin silencing by small RNA	PMID:15024409^[1]	ECO:0000315			P	Notes: Fig. 1.B. shows that rdr2-1 mutants lacking RDR2 do not accumulate any of the endogenous siRNA tested (siRNA02, AtSN1 siRNA, Cluster2 siRNA, or siRNA1003).	complete CACAO 8266
NOT\|involved_in	GO:0009751	response to salicylic acid	PMID:15024409^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:22302148^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:16839878^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26119694^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070919	production of siRNA involved in chromatin silencing by small RNA	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000554964 PomBase:SPAC6F12.09 TAIR:locus:2136068	P	Seeded From UniProt	complete
part_of	GO:0031380	nuclear RNA-directed RNA polymerase complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000554964 PomBase:SPAC6F12.09	C	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000554964 TAIR:locus:2006822 TAIR:locus:2136068 WB:WBGene00004508 dictyBase:DDB_G0280963	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000554964 PomBase:SPAC6F12.09 TAIR:locus:2114633 TAIR:locus:2136068 WB:WBGene00001214 WB:WBGene00004508	C	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000554964 PomBase:SPAC6F12.09 WB:WBGene00004508	F	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007855	F	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.48	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0696	F	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Xie, Z et al. (2004) Genetic and functional diversification of small RNA pathways in plants. PLoS Biol. 2 E104 PubMed GONUTS page
↑ López, A et al. (2011) The RNA silencing enzyme RNA polymerase v is required for plant immunity. PLoS Genet. 7 e1002434 PubMed GONUTS page
↑ Herr, AJ et al. (2005) RNA polymerase IV directs silencing of endogenous DNA. Science 308 118-20 PubMed GONUTS page
↑ Brosnan, CA et al. (2007) Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 104 14741-6 PubMed GONUTS page
↑ Xie, M et al. (2012) A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation. Nucleic Acids Res. 40 4422-31 PubMed GONUTS page
↑ Pontes, O et al. (2006) The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell 126 79-92 PubMed GONUTS page
↑ Deng, S et al. (2015) JMJ24 binds to RDR2 and is required for the basal level transcription of silenced loci in Arabidopsis. Plant J. 83 770-82 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15024409-1] 1.0 ^1.1 ^1.2 ^1.3 Xie, Z et al. (2004) Genetic and functional diversification of small RNA pathways in plants. PLoS Biol. 2 E104 PubMed GONUTS page

[PMID:22242006-2] López, A et al. (2011) The RNA silencing enzyme RNA polymerase v is required for plant immunity. PLoS Genet. 7 e1002434 PubMed GONUTS page

[PMID:15692015-3] Herr, AJ et al. (2005) RNA polymerase IV directs silencing of endogenous DNA. Science 308 118-20 PubMed GONUTS page

[PMID:17785412-4] Brosnan, CA et al. (2007) Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 104 14741-6 PubMed GONUTS page

[PMID:22302148-5] Xie, M et al. (2012) A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation. Nucleic Acids Res. 40 4422-31 PubMed GONUTS page

[PMID:16839878-6] Pontes, O et al. (2006) The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell 126 79-92 PubMed GONUTS page

[PMID:26119694-7] Deng, S et al. (2015) JMJ24 binds to RDR2 and is required for the basal level transcription of silenced loci in Arabidopsis. Plant J. 83 770-82 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ARATH:RDR2

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