PMID:15692015

Citation	Herr, AJ, Jensen, MB, Dalmay, T and Baulcombe, DC (2005) RNA polymerase IV directs silencing of endogenous DNA. Science 308:118-20
Abstract	Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.
Links	PubMed Online version:10.1126/science.1106910
Keywords	Amino Acid Sequence; Arabidopsis/enzymology; Arabidopsis/genetics; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Base Sequence; Chromatin/metabolism; DNA Methylation; DNA Transposable Elements; DNA, Plant/genetics; DNA, Plant/metabolism; DNA-Directed RNA Polymerases/chemistry; DNA-Directed RNA Polymerases/genetics; DNA-Directed RNA Polymerases/metabolism; Gene Silencing; Genes, Plant; Genetic Complementation Test; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Molecular Sequence Data; Mutation; Oryza sativa/enzymology; Oryza sativa/genetics; Plants, Genetically Modified; Protein Subunits/chemistry; Protein Subunits/genetics; Protein Subunits/metabolism; RNA Interference; RNA Polymerase II/metabolism; RNA, Plant/metabolism; RNA, Small Interfering/metabolism; Repetitive Sequences, Nucleic Acid; Transgenes
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