ARATH:RAD50

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	RAD50
Protein Name(s)	DNA repair protein RAD50 AtRAD50
External Links
UniProt	Q9SL02
EMBL	AF168748 AC006223 CP002685 AY139771 BT005823
PIR	D84727
RefSeq	NP_565733.1
UniGene	At.65745
ProteinModelPortal	Q9SL02
SMR	Q9SL02
PaxDb	Q9SL02
PRIDE	Q9SL02
EnsemblPlants	AT2G31970.1
GeneID	817756
KEGG	ath:AT2G31970
GeneFarm	4754
TAIR	AT2G31970
eggNOG	COG0419
HOGENOM	HOG000264309
InParanoid	Q9SL02
KO	K10866
OMA	VKDIENY
PhylomeDB	Q9SL02
Reactome	REACT_190926 REACT_238944 REACT_268332
PRO	PR:Q9SL02
Proteomes	UP000006548
ExpressionAtlas	Q9SL02
Genevestigator	Q9SL02
GO	GO:0000781 GO:0005737 GO:0030870 GO:0005634 GO:0005524 GO:0004518 GO:0008270 GO:0006302 GO:0051321 GO:0006312 GO:0016233 GO:0000723
Gene3D	3.40.50.300
InterPro	IPR027417 IPR004584 IPR013134
PANTHER	PTHR18867
Pfam	PF04423
SUPFAM	SSF52540
TIGRFAMs	TIGR00606
PROSITE	PS51131

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0016233	telomere capping	PMID:16990794^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006312	mitotic recombination	PMID:11306548^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:11169180^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19918061^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19918061^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:11172016^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070192	chromosome organization involved in meiotic cell cycle	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109292 PANTHER:PTN000429848	P	Seeded From UniProt	complete
enables	GO:0051880	G-quadruplex DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 SGD:S000005194	F	Seeded From UniProt	complete
enables	GO:0043047	single-stranded telomeric DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 SGD:S000005194	F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	C	Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	P	Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	C	Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034728 PANTHER:PTN000429848 TAIR:locus:2045437	P	Seeded From UniProt	complete
contributes_to	GO:0008408	3'-5' exonuclease activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	F	Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	P	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 SGD:S000005194	F	Seeded From UniProt	complete
contributes_to	GO:0004003	ATP-dependent DNA helicase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	F	Seeded From UniProt	complete
enables	GO:0003691	double-stranded telomeric DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 SGD:S000005194	F	Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 RGD:621542	C	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 RGD:621542	C	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	C	Seeded From UniProt	complete
involved_in	GO:0000722	telomere maintenance via recombination	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034728 PANTHER:PTN000429848 PomBase:SPAC1556.01c SGD:S000005194	P	Seeded From UniProt	complete
contributes_to	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000429848 UniProtKB:Q92878	F	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008408	P	Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004584	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004584	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004584	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004584	F	Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004584	C	Seeded From UniProt	complete
part_of	GO:0030870	Mre11 complex	PMID:19918061^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0051321	meiotic cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0469	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Vannier, JB et al. (2006) Two roles for Rad50 in telomere maintenance. EMBO J. 25 4577-85 PubMed GONUTS page
↑ Gherbi, H et al. (2001) Homologous recombination in planta is stimulated in the absence of Rad50. EMBO Rep. 2 287-91 PubMed GONUTS page
↑ Gallego, ME et al. (2001) Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity. Plant J. 25 31-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ronceret, A et al. (2009) PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus. Proc. Natl. Acad. Sci. U.S.A. 106 20121-6 PubMed GONUTS page
↑ Gallego, ME & White, CI (2001) RAD50 function is essential for telomere maintenance in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 98 1711-6 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16990794-1] Vannier, JB et al. (2006) Two roles for Rad50 in telomere maintenance. EMBO J. 25 4577-85 PubMed GONUTS page

[PMID:11306548-2] Gherbi, H et al. (2001) Homologous recombination in planta is stimulated in the absence of Rad50. EMBO Rep. 2 287-91 PubMed GONUTS page

[PMID:11169180-3] Gallego, ME et al. (2001) Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity. Plant J. 25 31-41 PubMed GONUTS page

[PMID:19918061-4] 4.0 ^4.1 ^4.2 Ronceret, A et al. (2009) PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus. Proc. Natl. Acad. Sci. U.S.A. 106 20121-6 PubMed GONUTS page

[PMID:11172016-5] Gallego, ME & White, CI (2001) RAD50 function is essential for telomere maintenance in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 98 1711-6 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ARATH:RAD50

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