ARATH:LHP1

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	LHP1 (synonyms: TFL2, TU8)
Protein Name(s)	Chromo domain-containing protein LHP1 Protein LIKE HETEROCHROMATIN PROTEIN 1 Protein TERMINAL FLOWER 2
External Links
UniProt	Q946J8
EMBL	AF387639 AB073490 AB006706 CP002688
RefSeq	NP_197271.1
UniGene	At.7322
ProteinModelPortal	Q946J8
SMR	Q946J8
BioGrid	16911
IntAct	Q946J8
PaxDb	Q946J8
PRIDE	Q946J8
EnsemblPlants	AT5G17690.1
GeneID	831635
KEGG	ath:AT5G17690
TAIR	AT5G17690
eggNOG	NOG263528
HOGENOM	HOG000078802
InParanoid	Q946J8
OMA	RIARMGN
PhylomeDB	Q946J8
Proteomes	UP000006548
Genevestigator	Q946J8
GO	GO:0009507 GO:0000791 GO:0005720 GO:0003677 GO:0003935 GO:0035064 GO:0030154 GO:0016568 GO:0006325 GO:0006342 GO:0009908 GO:0009825 GO:0009910 GO:0045814 GO:0045857 GO:0009648 GO:0048573 GO:0010016 GO:0006351 GO:0010048
InterPro	IPR017984 IPR023780 IPR000953 IPR016197 IPR023779
Pfam	PF00385
PRINTS	PR00504
SMART	SM00298
SUPFAM	SSF54160
PROSITE	PS00598 PS50013

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009851	auxin biosynthetic process	PMID:21251106^[1]	ECO:0000315			P	Figure 2b, Figure 3b	complete
	GO:0045449	regulation of transcription	PMID:21304947^[2]	ECO:0000315			P	See Fig. 6A.	complete
	GO:0048366	leaf development	PMID:11731464^[3]	ECO:0000315			P	See Fig. 1.	complete
	GO:0010080	regulation of floral meristem growth	PMID:11731464^[3]	ECO:0000315			P	See Table 1.	complete
	GO:0048437	floral organ development	PMID:11731464^[3]	ECO:0000315			P	See Fig. 1.	complete
	GO:0045449	regulation of transcription	PMID:11731464^[3]	ECO:0000315			P	See Fig. 6A.	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:27495811^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:27495811^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:27495811^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21304947^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:23203051^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
NOT\|enables	GO:0008686	3,4-dihydroxy-2-butanone-4-phosphate synthase activity	PMID:23203051^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003935	GTP cyclohydrolase II activity	PMID:23203051^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048573	photoperiodism, flowering	PMID:18799658^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0048364	root development	PMID:9611176^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045857	negative regulation of molecular function, epigenetic	PMID:20671111^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:16549797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:17676062^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035064	methylated histone binding	PMID:17542647^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010048	vernalization response	PMID:16682972^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010016	shoot system morphogenesis	PMID:9611176^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009910	negative regulation of flower development	PMID:9611176^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009825	multidimensional cell growth	PMID:9611176^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009648	photoperiodism	PMID:9611176^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:16549797^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:17542647^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:16244868^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005720	nuclear heterochromatin	PMID:16361394^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16972870^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	PMID:16244868^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008251	C	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
involved_in	GO:0009908	flower development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0287	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rizzardi, K et al. (2011) TFL2/LHP1 is involved in auxin biosynthesis through positive regulation of YUCCA genes. Plant J. 65 897-906 PubMed GONUTS page
↑ ^2.0 ^2.1 Latrasse, D et al. (2011) Control of flowering and cell fate by LIF2, an RNA binding partner of the polycomb complex component LHP1. PLoS ONE 6 e16592 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudin, V et al. (2001) Mutations in LIKE HETEROCHROMATIN PROTEIN 1 affect flowering time and plant architecture in Arabidopsis. Development 128 4847-58 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Molitor, AM et al. (2016) The Arabidopsis hnRNP-Q Protein LIF2 and the PRC1 Subunit LHP1 Function in Concert to Regulate the Transcription of Stress-Responsive Genes. Plant Cell 28 2197-2211 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hiltunen, HM et al. (2012) Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis. Int J Mol Sci 13 14086-105 PubMed GONUTS page
↑ Pouteau, S et al. (2008) Diversification of photoperiodic response patterns in a collection of early-flowering mutants of Arabidopsis. Plant Physiol. 148 1465-73 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Larsson, AS et al. (1998) The TERMINAL FLOWER2 (TFL2) gene controls the reproductive transition and meristem identity in Arabidopsis thaliana. Genetics 149 597-605 PubMed GONUTS page
↑ Kim, DH et al. (2010) Vernalization-mediated VIN3 Induction Overcomes the LIKE-HETEROCHROMATIN PROTEIN1/POLYCOMB REPRESSION COMPLEX2-mediated epigenetic repression. Plant Physiol. 154 949-57 PubMed GONUTS page
↑ ^9.0 ^9.1 Mylne, JS et al. (2006) LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC. Proc. Natl. Acad. Sci. U.S.A. 103 5012-7 PubMed GONUTS page
↑ Zhang, X et al. (2007) The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation. Nat. Struct. Mol. Biol. 14 869-71 PubMed GONUTS page
↑ ^11.0 ^11.1 Turck, F et al. (2007) Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27. PLoS Genet. 3 e86 PubMed GONUTS page
↑ Sung, S et al. (2006) Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1. Nat. Genet. 38 706-10 PubMed GONUTS page
↑ ^13.0 ^13.1 Libault, M et al. (2005) The Arabidopsis LHP1 protein is a component of euchromatin. Planta 222 910-25 PubMed GONUTS page
↑ Zemach, A et al. (2006) Different domains control the localization and mobility of LIKE HETEROCHROMATIN PROTEIN1 in Arabidopsis nuclei. Plant Cell 18 133-45 PubMed GONUTS page
↑ Germann, S et al. (2006) DamID, a new tool for studying plant chromatin profiling in vivo, and its use to identify putative LHP1 target loci. Plant J. 48 153-63 PubMed GONUTS page

[PMID:21251106-1] Rizzardi, K et al. (2011) TFL2/LHP1 is involved in auxin biosynthesis through positive regulation of YUCCA genes. Plant J. 65 897-906 PubMed GONUTS page

[PMID:21304947-2] 2.0 ^2.1 Latrasse, D et al. (2011) Control of flowering and cell fate by LIF2, an RNA binding partner of the polycomb complex component LHP1. PLoS ONE 6 e16592 PubMed GONUTS page

[PMID:11731464-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudin, V et al. (2001) Mutations in LIKE HETEROCHROMATIN PROTEIN 1 affect flowering time and plant architecture in Arabidopsis. Development 128 4847-58 PubMed GONUTS page

[PMID:27495811-4] 4.0 ^4.1 ^4.2 Molitor, AM et al. (2016) The Arabidopsis hnRNP-Q Protein LIF2 and the PRC1 Subunit LHP1 Function in Concert to Regulate the Transcription of Stress-Responsive Genes. Plant Cell 28 2197-2211 PubMed GONUTS page

[PMID:23203051-5] 5.0 ^5.1 ^5.2 Hiltunen, HM et al. (2012) Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis. Int J Mol Sci 13 14086-105 PubMed GONUTS page

[PMID:18799658-6] Pouteau, S et al. (2008) Diversification of photoperiodic response patterns in a collection of early-flowering mutants of Arabidopsis. Plant Physiol. 148 1465-73 PubMed GONUTS page

[PMID:9611176-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Larsson, AS et al. (1998) The TERMINAL FLOWER2 (TFL2) gene controls the reproductive transition and meristem identity in Arabidopsis thaliana. Genetics 149 597-605 PubMed GONUTS page

[PMID:20671111-8] Kim, DH et al. (2010) Vernalization-mediated VIN3 Induction Overcomes the LIKE-HETEROCHROMATIN PROTEIN1/POLYCOMB REPRESSION COMPLEX2-mediated epigenetic repression. Plant Physiol. 154 949-57 PubMed GONUTS page

[PMID:16549797-9] 9.0 ^9.1 Mylne, JS et al. (2006) LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC. Proc. Natl. Acad. Sci. U.S.A. 103 5012-7 PubMed GONUTS page

[PMID:17676062-10] Zhang, X et al. (2007) The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation. Nat. Struct. Mol. Biol. 14 869-71 PubMed GONUTS page

[PMID:17542647-11] 11.0 ^11.1 Turck, F et al. (2007) Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27. PLoS Genet. 3 e86 PubMed GONUTS page

[PMID:16682972-12] Sung, S et al. (2006) Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1. Nat. Genet. 38 706-10 PubMed GONUTS page

[PMID:16244868-13] 13.0 ^13.1 Libault, M et al. (2005) The Arabidopsis LHP1 protein is a component of euchromatin. Planta 222 910-25 PubMed GONUTS page

[PMID:16361394-14] Zemach, A et al. (2006) Different domains control the localization and mobility of LIKE HETEROCHROMATIN PROTEIN1 in Arabidopsis nuclei. Plant Cell 18 133-45 PubMed GONUTS page

[PMID:16972870-15] Germann, S et al. (2006) DamID, a new tool for studying plant chromatin profiling in vivo, and its use to identify putative LHP1 target loci. Plant J. 48 153-63 PubMed GONUTS page

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ARATH:LHP1

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