PMID:11731464

Citation	Gaudin, V, Libault, M, Pouteau, S, Juul, T, Zhao, G, Lefebvre, D and Grandjean, O (2001) Mutations in LIKE HETEROCHROMATIN PROTEIN 1 affect flowering time and plant architecture in Arabidopsis. Development 128:4847-58
Abstract	In plants, recent studies have demonstrated links between the regulation of developmental processes and chromatin dynamics and organisation. Analysis of new mutations affecting overall plant architecture, leaf development and flowering time in Arabidopsis has allowed us to clone and characterise LHP1, the Drosophila heterochromatin protein 1 (HP1) homologue. LHP1 has the chromo and chromo shadow domains central to the function of animal proteins. Yeast two hybrid studies and in planta deletion experiments suggest similar modes of action in plants and animals via homodimer formation. In vivo localisation experiments revealed a specific subnuclear protein distribution in foci throughout the nucleus. Our data suggest that LHP1 may act as a main regulator of gene expression in plants, through formation of heterochromatin-like repressive complexes, to control developmental pathways involved in organ and cell size, and the vegetative to reproductive phase transition.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Arabidopsis/genetics; Arabidopsis/growth & development; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Base Sequence; Cell Nucleus/genetics; Chromosomal Proteins, Non-Histone/chemistry; Chromosomal Proteins, Non-Histone/genetics; Cloning, Molecular; Conserved Sequence; DNA, Complementary/genetics; DNA, Plant/genetics; Dimerization; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant; Molecular Sequence Data; Mutation; Plant Leaves/growth & development; Protein Structure, Tertiary; Sequence Homology, Amino Acid
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
ARATH:LHP1		GO:0048437: floral organ development	ECO:0000315:		P		See Fig. 1.	complete
ARATH:LHP1		GO:0048366: leaf development	ECO:0000315:		P		See Fig. 1.	complete
ARATH:LHP1		GO:0045449: regulation of transcription	ECO:0000315:		P		See Fig. 6A.	complete

References

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