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YEAST:UBP10

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) UBP10 (synonyms: DOT4)
Protein Name(s) Ubiquitin carboxyl-terminal hydrolase 10

Deubiquitinating enzyme 10 Disrupter of telomere silencing protein 4 Ubiquitin thioesterase 10 Ubiquitin-specific-processing protease 10

External Links
UniProt P53874
EMBL Z71462
BK006947
PIR S63141
RefSeq NP_014213.2
ProteinModelPortal P53874
SMR P53874
BioGrid 35647
DIP DIP-6664N
IntAct P53874
MINT MINT-643556
MEROPS C19.088
iPTMnet P53874
MaxQB P53874
PeptideAtlas P53874
EnsemblFungi [example_ID YNL186W]
GeneID 855535
KEGG sce:YNL186W
EuPathDB FungiDB:YNL186W
SGD S000005130
GeneTree ENSGT00830000129465
HOGENOM HOG000248158
InParanoid P53874
KO K11873
OMA YVCEKCH
OrthoDB EOG7R2BSX
BioCyc YEAST:G3O-33197-MONOMER
NextBio 979592
PRO PR:P53874
Proteomes UP000002311
GO GO:0000781
GO:0005730
GO:0005634
GO:0004843
GO:0006348
GO:0016578
GO:0016579
GO:0006511
InterPro IPR001394
IPR018200
IPR028889
Pfam PF00443
PROSITE PS00973
PS50235

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:11914276[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0099114

chromatin silencing at subtelomere

PMID:26587833[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:22829782[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:P15873)

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:15721261[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:15721261[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016578

histone deubiquitination

PMID:22829782[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006348

chromatin silencing at telomere

PMID:15721261[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:22902402[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10490600[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

PMID:10490600[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005632
FB:FBgn0016756
FB:FBgn0260936
MGI:MGI:107698
MGI:MGI:107699
MGI:MGI:1270128
MGI:MGI:1916977
MGI:MGI:1919594
MGI:MGI:1924050
MGI:MGI:2182061
MGI:MGI:3051498
MGI:MGI:3643640
PANTHER:PTN002541993
RGD:1306915
SGD:S000000953
SGD:S000001418
SGD:S000002280
SGD:S000004920
SGD:S000005130
SGD:S000005650
TAIR:locus:2083440
TAIR:locus:2121959
UniProtKB:A0A0B4KI06
UniProtKB:O75317
UniProtKB:O94782
UniProtKB:P45974
UniProtKB:P62068
UniProtKB:Q14694
UniProtKB:Q6R6M4
UniProtKB:Q70CQ2
UniProtKB:Q86T82
UniProtKB:Q8NB14
UniProtKB:Q93008
UniProtKB:Q93009
UniProtKB:Q96RU2
UniProtKB:Q9BXU7
UniProtKB:Q9FPS9
UniProtKB:Q9H9J4
UniProtKB:Q9P275
UniProtKB:Q9P2H5
UniProtKB:Q9UHP3
WB:WBGene00010406
dictyBase:DDB_G0275021

P

Seeded From UniProt

complete

enables

GO:0004843

thiol-dependent ubiquitin-specific protease activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005632
FB:FBgn0016756
FB:FBgn0030366
FB:FBgn0260936
MGI:MGI:107698
MGI:MGI:107699
MGI:MGI:1924050
MGI:MGI:2182061
MGI:MGI:3051372
MGI:MGI:3051498
MGI:MGI:3643640
PANTHER:PTN002541993
PomBase:SPBP8B7.21
RGD:1306915
SGD:S000000163
SGD:S000000262
SGD:S000000953
SGD:S000001418
SGD:S000001806
SGD:S000002280
SGD:S000004920
SGD:S000005130
SGD:S000005650
TAIR:locus:2010622
TAIR:locus:2083440
TAIR:locus:2140074
UniProtKB:O75317
UniProtKB:O94782
UniProtKB:P45974
UniProtKB:P62068
UniProtKB:Q0WX57
UniProtKB:Q14694
UniProtKB:Q6QN14
UniProtKB:Q6R6M4
UniProtKB:Q70CQ2
UniProtKB:Q84WU2
UniProtKB:Q86T82
UniProtKB:Q8LAM0
UniProtKB:Q8NB14
UniProtKB:Q92995
UniProtKB:Q93009
UniProtKB:Q96K76
UniProtKB:Q96RU2
UniProtKB:Q96V54
UniProtKB:Q9FPS0
UniProtKB:Q9FPS9
UniProtKB:Q9FPT1
UniProtKB:Q9H9J4
UniProtKB:Q9P275
UniProtKB:Q9P2H5
UniProtKB:Q9UHP3
WB:WBGene00010406
WB:WBGene00011216

F

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2182061
PANTHER:PTN002541993
UniProtKB:O75317
UniProtKB:Q14694
UniProtKB:Q70CQ2
UniProtKB:Q86T82
UniProtKB:Q92995
UniProtKB:Q93009

F

Seeded From UniProt

complete

part_of

GO:0099115

chromosome, subtelomeric region

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0099114

C

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018200

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001394

P

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001394
InterPro:IPR018200

F

Seeded From UniProt

complete

enables

GO:0036459

thiol-dependent ubiquitinyl hydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.4.19.12

F

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0779
UniProtKB-SubCell:SL-0276

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Kumar, A et al. (2002) Subcellular localization of the yeast proteome. Genes Dev. 16 707-19 PubMed GONUTS page
  2. ↑ Larin, ML et al. (2015) Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin. PLoS Genet. 11 e1005425 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gallego-Sánchez, A et al. (2012) Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae. PLoS Genet. 8 e1002826 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Emre, NC et al. (2005) Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol. Cell 17 585-94 PubMed GONUTS page
  5. ↑ Richardson, LA et al. (2012) A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Cell Rep 2 372-85 PubMed GONUTS page
  6. ↑ 6.0 6.1 Kahana, A & Gottschling, DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol. Cell. Biol. 19 6608-20 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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