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YEAST:TOR1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) TOR1 (synonyms: DRR1)
Protein Name(s) Serine/threonine-protein kinase TOR1

Dominant rapamycin resistance protein 1 Phosphatidylinositol kinase homolog TOR1 Target of rapamycin kinase 1

External Links
UniProt P35169
EMBL L19540
X74857
Z49566
L47993
BK006943
PIR S57085
RefSeq NP_012600.1
PDB 1W1N
2KIO
2KIT
PDBsum 1W1N
2KIO
2KIT
ProteinModelPortal P35169
SMR P35169
BioGrid 33823
DIP DIP-917N
IntAct P35169
MINT P35169
STRING 4932.YJR066W
iPTMnet P35169
MaxQB P35169
PaxDb P35169
PRIDE P35169
EnsemblFungi YJR066W
GeneID 853529
KEGG sce:YJR066W
EuPathDB FungiDB:YJR066W
SGD S000003827
GeneTree ENSGT00910000144231
HOGENOM HOG000163215
InParanoid P35169
KO K07203
OMA VCSLCIC
OrthoDB EOG092C00HJ
BioCyc YEAST:G3O-31699-MONOMER
BRENDA 2.7.1.137
EvolutionaryTrace P35169
PRO PR:P35169
Proteomes UP000002311
GO GO:0005737
GO:0010008
GO:0031234
GO:0000329
GO:0000139
GO:0005634
GO:0005886
GO:0031931
GO:0005524
GO:0044877
GO:0004672
GO:0004674
GO:0006974
GO:0034605
GO:0034599
GO:0001300
GO:0006281
GO:0031505
GO:0051321
GO:0031930
GO:0010507
GO:0044387
GO:0042790
GO:0018105
GO:0051726
GO:0001558
GO:1905356
GO:0090153
GO:0042254
GO:0031929
GO:0006413
Gene3D 1.10.1070.11
1.20.120.150
1.25.10.10
InterPro IPR011989
IPR016024
IPR024585
IPR003152
IPR009076
IPR036738
IPR011009
IPR000403
IPR036940
IPR018936
IPR003151
IPR014009
IPR026683
PANTHER PTHR11139:SF9
Pfam PF11865
PF02259
PF02260
PF08771
PF00454
SMART SM01346
SM01343
SM00146
SUPFAM SSF47212
SSF48371
SSF56112
PROSITE PS51189
PS51190
PS00915
PS00916
PS50290

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006468

protein phosphorylation

PMID:18270585[1]

ECO:0000314

P

Figure 4C shows that " Gln3-myc13p runs faster in hsf1 R206S, F256S cells compared to HSF1 cells." The TOR kinase controls the phosphorylation of HSF1. Dephosphorylated proteins run faster than phosphorylated in yeast.

complete
CACAO 13282

part_of

GO:0000329

fungal-type vacuole membrane

PMID:26928762[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1905356

regulation of snRNA pseudouridine synthesis

PMID:27268497[3]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001686

P

Seeded From UniProt

complete

involved_in

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

PMID:16980405[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:P06782)

Seeded From UniProt

complete

involved_in

GO:0034605

cellular response to heat

PMID:27922823[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003861

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:27922823[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003861

P

Seeded From UniProt

complete

involved_in

GO:0001300

chronological cell aging

PMID:27922823[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003861

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:26582391[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(SGD:S000000232)

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:26582391[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(SGD:S000000232)

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:25046117[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:19748353[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:18723607[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18723607[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090153

regulation of sphingolipid biosynthetic process

PMID:23363605[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

PMID:8741837[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042790

nucleolar large rRNA transcription by RNA polymerase I

PMID:16900101[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042254

ribosome biogenesis

PMID:10198052[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

PMID:12408816[14]

ECO:0000353

physical interaction evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031930

mitochondria-nucleus signaling pathway

PMID:11997479[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:12719473[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:8186460[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:12408816[14]

ECO:0000305

curator inference used in manual assertion

GO:0031931

P

Seeded From UniProt

complete

involved_in

GO:0031505

fungal-type cell wall organization

PMID:14736892[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

PMID:12631735[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010507

negative regulation of autophagy

PMID:9461583[20]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001686

P

part_of:(GO:0006995)

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

PMID:12719473[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

PMID:9096347[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:17698581[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

PMID:8741837[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10973982[23]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16900101[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16900101[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:10329624[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001558

regulation of cell growth

PMID:12171921[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:12719473[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

PMID:12719473[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0038202

TORC1 signaling

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
PANTHER:PTN000124327
PomBase:SPBC216.07c
UniProtKB:P42345

P

Seeded From UniProt

complete

part_of

GO:0031932

TORC2 complex

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
PANTHER:PTN000124327
PomBase:SPBC30D10.10c
UniProtKB:P42345
WB:WBGene00002583
dictyBase:DDB_G0281569

C

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
MGI:MGI:1928394
PANTHER:PTN000124327
PomBase:SPBC216.07c
RGD:68371
UniProtKB:P42345
WB:WBGene00002583

C

Seeded From UniProt

complete

involved_in

GO:0016242

negative regulation of macroautophagy

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
MGI:MGI:1928394
PANTHER:PTN000124327
UniProtKB:P42345

P

Seeded From UniProt

complete

involved_in

GO:0010507

negative regulation of autophagy

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1928394
PANTHER:PTN000124327
PomBase:SPBC216.07c
RGD:68371
SGD:S000001686
SGD:S000003827
UniProtKB:P42345
UniProtKB:Q9FR53

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0045035
FB:FBgn0053554
MGI:MGI:104779
MGI:MGI:1928394
PANTHER:PTN000124197
RGD:1593265
RGD:68371
SGD:S000000340
SGD:S000001141
SGD:S000003827
UniProtKB:P78527
UniProtKB:Q13315
UniProtKB:Q96Q15
UniProtKB:Q9FR53
UniProtKB:Q9Y4A5
WB:WBGene00000226
WB:WBGene00007028

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1928394
PANTHER:PTN000124327
PomBase:SPBC216.07c
PomBase:SPBC30D10.10c
RGD:68371
SGD:S000001686
SGD:S000003827
UniProtKB:P42345

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026683

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018936
InterPro:IPR036940

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009076
InterPro:IPR036738

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005773

vacuole

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0926

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Bandhakavi, S et al. (2008) Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis. PLoS ONE 3 e1598 PubMed GONUTS page
  2. ↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
  3. ↑ Wu, G et al. (2016) The TOR signaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA. RNA 22 1146-52 PubMed GONUTS page
  4. ↑ Orlova, M et al. (2006) Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryotic Cell 5 1831-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Aguilar-Lopez, JL et al. (2016) Slm35 links mitochondrial stress response and longevity through TOR signaling pathway. Aging (Albany NY) 8 3255-3271 PubMed GONUTS page
  6. ↑ 6.0 6.1 Yerlikaya, S et al. (2016) TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol. Biol. Cell 27 397-409 PubMed GONUTS page
  7. ↑ Kira, S et al. (2014) Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy. Autophagy 10 1565-78 PubMed GONUTS page
  8. ↑ Binda, M et al. (2009) The Vam6 GEF controls TORC1 by activating the EGO complex. Mol. Cell 35 563-73 PubMed GONUTS page
  9. ↑ 9.0 9.1 Sturgill, TW et al. (2008) TOR1 and TOR2 have distinct locations in live cells. Eukaryotic Cell 7 1819-30 PubMed GONUTS page
  10. ↑ Shimobayashi, M et al. (2013) TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Mol. Biol. Cell 24 870-81 PubMed GONUTS page
  11. ↑ 11.0 11.1 Barbet, NC et al. (1996) TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7 25-42 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Li, H et al. (2006) Nutrient regulates Tor1 nuclear localization and association with rDNA promoter. Nature 442 1058-61 PubMed GONUTS page
  13. ↑ Powers, T & Walter, P (1999) Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 10 987-1000 PubMed GONUTS page
  14. ↑ 14.0 14.1 Loewith, R et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10 457-68 PubMed GONUTS page
  15. ↑ Crespo, JL et al. (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. U.S.A. 99 6784-9 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 16.3 Chen, EJ & Kaiser, CA (2003) LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161 333-47 PubMed GONUTS page
  17. ↑ Helliwell, SB et al. (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell 5 105-18 PubMed GONUTS page
  18. ↑ Reinke, A et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J. Biol. Chem. 279 14752-62 PubMed GONUTS page
  19. ↑ Wedaman, KP et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14 1204-20 PubMed GONUTS page
  20. ↑ Noda, T & Ohsumi, Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273 3963-6 PubMed GONUTS page
  21. ↑ Zheng, XF & Schreiber, SL (1997) Target of rapamycin proteins and their kinase activities are required for meiosis. Proc. Natl. Acad. Sci. U.S.A. 94 3070-5 PubMed GONUTS page
  22. ↑ Shen, C et al. (2007) TOR signaling is a determinant of cell survival in response to DNA damage. Mol. Cell. Biol. 27 7007-17 PubMed GONUTS page
  23. ↑ Kunz, J et al. (2000) HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J. Biol. Chem. 275 37011-20 PubMed GONUTS page
  24. ↑ Jiang, Y & Broach, JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18 2782-92 PubMed GONUTS page
  25. ↑ Torres, J et al. (2002) Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast. J. Biol. Chem. 277 43495-504 PubMed GONUTS page
  26. ↑ 26.0 26.1 26.2 26.3 26.4 26.5 26.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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